Voice changes in reproductive disorders, thyroid disorders and diabetes: a review

Stogowska, Ewa; Kamiński, Karol; Ziółko, Bartosz; Kowalska, Irina

doi:10.1530/ec-21-0505

Cited by 6 publications

(4 citation statements)

References 55 publications

(107 reference statements)

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“…As it is suggested to consider unwanted excess hair growth and/or female pattern hair loss as important, regardless of apparent clinical severity, in our opinion, physicians should also pay attention to any complaints of patients for vocal alterations (as tone drops or hoarseness) that could exacerbate low self-esteem and negative body image, resulting in social and/or sexual discomfort. Besides PCOS, the human voice can be affected also in case of other endocrine pathologies such as thyroid disorders and type 2 diabetes mellitus, but there is uncertain evidence on the topic [38].…”

Section: Discussionmentioning

confidence: 99%

Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis

Turetta,

Colizza,

Giannini

et al. 2024

Gynecol Obstet Invest

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Introduction: Polycystic ovary syndrome (PCOS) is a common hormonal disorder among young women, correlated with hyperandrogenism. Among the symptoms of PCOS, vocal alterations are quite unknown. Dysphonia may be related to hyperandrogenism, and there is no consensus about its prevalence and the severity of vocal disorders, which can cause noticeable discomfort. Methods: A systematic review of the literature was conducted. Four studies on PCOS that evaluated the phonatory system were included, for a total of 174 patients (96 PCOS, 78 controls) and a meta-analysis on comparable data was performed. Results: Four studies evaluated parameters related to vocal symptomatology, altered audiometric examination, and findings at the laryngoscopy in patients affected by PCOS versus controls. Although the individual studies showed increased incidence of alterations and a tendency to speech fatigue in women with PCOS, when the results of studies were pulled in metanalysis the overall difference was not statistically significant. The studies themselves were very different from each other, thereby it is hard to draw any firm conclusions. Discussion/Conclusions: The aim of this study was to assess the prevalence of vocal alterations, the correlation with hyperandrogenism, the quality of life, and the voice changes after starting a therapy for PCOS. The present meta-analysis failed to find any difference in terms of PCOS and control cohort. However, the lack of high-quality studies makes it difficult to draw firm conclusions. New and larger studies or big population program data are therefore warranted.

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Section: Discussionmentioning

confidence: 99%

Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis

Turetta,

Colizza,

Giannini

et al. 2024

Gynecol Obstet Invest

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“…The human larynx is a hormone‐responsive organ, exhibiting variations in its cytology, for instance, during the menstrual cycle or due to fluctuations in thyroid hormone levels 6,7 . Receptors for both male and female sex hormones are present in the epithelium and LP of VF in both sexes, with a predominance in the macula flava 8 …”

Section: Introductionmentioning

confidence: 99%

“…5 The human larynx is a hormone-responsive organ, exhibiting variations in its cytology, for instance, during the menstrual cycle or due to fluctuations in thyroid hormone levels. 6,7 Receptors for both male and female sex hormones are present in the epithelium and LP of VF in both sexes, with a predominance in the macula flava. 8 In individuals assigned female at birth, the administration of supraphysiological levels of testosterone results in voice deepening, a phenomenon first described in 1964.…”

Section: Introductionmentioning

confidence: 99%

Effect of Testosterone on the Thyroarytenoid Muscle and Lamina Propria of Female Rat Vocal Folds

Aires,

de Oliveira,

do Amaral

et al. 2023

The Laryngoscope

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ObjectiveTo analyze the effects of androgen therapy on the thyroarytenoid (TA) muscle, expression of androgen receptors (ARs) and hyaluronic acid (HA) concentration in the vocal folds (VFs) of adult female rats.MethodsTwenty‐one adult female Wistar rats were divided into experimental and control groups. The experimental group received weekly intramuscular injections of nandrolone decanoate for 9 weeks. Following euthanasia and dissection of the VFs, histomorphometric analysis of the TA muscle, immunohistochemical evaluation of ARs, and measurement of HA concentration using the ELISA‐like fluorimetric method were performed.ResultsThe experimental group exhibited a significantly larger mean fiber cross‐sectional area in the TA muscle compared to the control group (434.3 ± 68.6 μm2 versus 305.7 ± 110.1 μm2; p = 0.029), indicating muscle hypertrophy. There was no significant difference in the number of muscle fibers. The experimental group showed higher expression of ARs in the lamina propria (62.0% ± 30.3% versus 22.0% ± 22.8%; p = 0.046) and in the TA muscle (45.0% ± 22.6% versus 18.3% ± 9.8%; p = 0.024). There was no significant difference in the concentration of HA.ConclusionExposure of adult female rats to androgen therapy resulted in hypertrophy of the TA muscle and increased expression of ARs in the VFs. The TA muscle seems to be the primary target of testosterone action in the VF, and the up‐regulation of ARs might contribute to the persistent deepening of the voice.Level of EvidenceNot applicable Laryngoscope, 2023

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“…Although some systematic reviews have been prepared recently, they are usually dedicated to certain groups of disorders (Cummins et Stogowska et al, 2022). To the best of our knowledge, there is a lack of a systematic review of voice analysis in connection with somatic disorders.…”

Section: Introductionmentioning

confidence: 99%

Speech Analysis as a Tool for Detection and Monitoring of Medical Conditions: A review

2023

Archives of Acoustics

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The goal of this article is to present and compare recent approaches which use speech and voice analysis as biomarkers for screening tests and monitoring of some diseases. The article takes into account metabolic, respiratory, cardiovascular, endocrine, and nervous system disorders. A selection of articles was performed to identify studies that assess voice features quantitatively in selected disorders by acoustic and linguistic voice analysis. Information was extracted from each paper in order to compare various aspects of datasets, speech parameters, methods of applied analysis and obtained results. 110 research papers were reviewed and 47 databases were summarized. Speech analysis is a promising method for early diagnosis of certain disorders. Advanced computer voice analysis with machine learning algorithms combined with the widespread availability of smartphones allows diagnostic analysis to be conducted during the patient's visit to the doctor or at the patient's home during a telephone conversation. Speech analysis is a simple, low-cost, non-invasive and easy-toprovide method of medical diagnosis. These are remarkable advantages, but there are also disadvantages. The effectiveness of disease diagnoses varies from 65% up to 99%. For that reason it should be treated as a medical screening test and should be an indication of the need for classic medical tests.

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Voice changes in reproductive disorders, thyroid disorders and diabetes: a review

Cited by 6 publications

References 55 publications

Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis

Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis

Effect of Testosterone on the Thyroarytenoid Muscle and Lamina Propria of Female Rat Vocal Folds

Speech Analysis as a Tool for Detection and Monitoring of Medical Conditions: A review

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