Voice and Swallowing in Patients Enrolled in a Larynx Preservation Trial

Angelis, Elisabete Carrara-de; Feher, Olavo; Barros, Ana Paula Brandão; Nishimoto, Inês Nobuko; Kowalski, Luiz Paulo

doi:10.1001/archotol.129.7.733

Cited by 83 publications

(57 citation statements)

References 21 publications

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“…Swallowing dysfunction has been correlated with dose and volume parameters of the upper aerodigestive tract (14)(15)(16). Organ preservation treatment impairs movement of structures that are essential for effective swallowing (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Organ Preservation With Concurrent Chemoradiation for Advanced Laryngeal Cancer: Are We Succeeding?

Lambert

Fortin

Soulières

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionmentioning

confidence: 99%

Organ Preservation With Concurrent Chemoradiation for Advanced Laryngeal Cancer: Are We Succeeding?

Lambert

Fortin

Soulières

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Common treatment sequelae included prolonged tube feedings, recurrent aspiration pneumonia, and radiation-induced oropharyngeal stricture. In one study, the rate of silent aspiration was 36% (5/14) following chemoradiation for larynx preservation [16] . The limitations of these studies were the small number of patients and the short follow-up.…”

Section: Discussionmentioning

confidence: 99%

Aspiration Rate following Nonsurgical Therapy for Laryngeal Cancer

Nguyen

Moltz

Frank

et al. 2006

ORL

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The aim of this study was to evaluate the aspiration rate following nonsurgical therapy, i.e. chemoradiation or radiation alone for laryngeal cancer. Modified barium swallow was performed in 43 patients who complained of dysphagia following chemoradiation (n = 22) or radiation alone (n = 21) for laryngeal cancer. Patients were selected if they were cancer free at the time of the swallowing study. Dysphagia severity was graded on a scale of 1–7. Patients were grouped according to the dysphagia severity: no aspiration (grade 1–4), and severe (grade 5–7). Mean and median dysphagia grades were 4.4/5 and 3.5/3 for chemoradiation and radiation, respectively. Aspiration occurred in 12 patients (54%) of the chemoradiation group and 7 (33%) of the radiation alone group (p = 0.13). There was a higher proportion of patients with large tumor (T3–T4) in the chemoradiation group (64%) compared to the radiation group (5%) (p = 0.0001). Aspiration is a significant source of morbidity in patients treated for laryngeal cancer with chemoradiation or radiation alone. Aspiration occurred in both groups. Although the observed difference in aspiration rates did not achieve statistical significance, the higher aspiration rate in the chemoradiation group may be due to a higher proportion of large tumors, to the additional toxic effect of chemotherapy, or to the small number of patients in both groups. Diagnostic studies such as modified barium swallow should be part of future laryngeal cancer prospective studies to assess the prevalence of aspiration as it may be silent.

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“…7,8 A close match is the study by Carrara-de Angelis et al, 15 in which three trained listeners prospectively analyzed voice quality of 43 patients with hypopharyngeal and laryngeal cancer treated with CCRT using the GRBAS scale. Normal voice was perceived in one (7%) of the 15 patients, mild dysphonia in four (27%), moderate in six (40%), and severe in four (27%) at 2-9 months after CCRT.…”

Section: E30mentioning

confidence: 98%

Pre- and Posttreatment Voice and Speech Outcomes in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy: Expert Listeners’ and Patient’s Perception

et al. 2012

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Voice and Swallowing in Patients Enrolled in a Larynx Preservation Trial

Abstract: Laryngeal preservation resulted in voice and swallowing abnormalities, but they tend to be mild to moderate, allowing intelligible communication and efficient swallowing in most patients.

Cited by 83 publications

References 21 publications

Organ Preservation With Concurrent Chemoradiation for Advanced Laryngeal Cancer: Are We Succeeding?

Organ Preservation With Concurrent Chemoradiation for Advanced Laryngeal Cancer: Are We Succeeding?

Aspiration Rate following Nonsurgical Therapy for Laryngeal Cancer

Pre- and Posttreatment Voice and Speech Outcomes in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy: Expert Listeners’ and Patient’s Perception

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