Vogt‐Koyanagi‐Harada syndrome in children compared to adults

Tabbara, Khalid F.; Chavis, Pamela S.; Freeman, William R.

doi:10.1034/j.1600-0420.1998.760619.x

Cited by 89 publications

(85 citation statements)

References 12 publications

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“…1 However, VKH disease can occur in the paediatric population, but the prognosis in this subpopulation appears to be quite variable. 8,[11][12][13] It is possible that differences in interval between onset of uveitis and starting treatment, type of treatment, and/or duration of treatment could have played a role in the differences in outcomes reported by previous studies. 8,[11][12][13] To determine prognostic factors for final visual acuity, development of complications, and recurrence of inflammation, we analysed 23 children with VKH disease who were followed from disease onset and treated with systemic corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

Vogt-Koyanagi-Harada disease in children

El‐Asrar

Alkharashi

Aldibhi

et al. 2007

Eye

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Purpose To identify prognostic factors for outcome in children with Vogt-Koyanagi-Harada (VKH) disease. Methods All children 16 years and younger with acute uveitis associated with VKH disease treated between 1999 and 2006 were reviewed. Results Twenty-three children (46 eyes) were identified; 20 (87%) girls and three (13%) boys with a mean age at presentation of 12.572.4 years. Mean follow-up period was 48.6730.8 months. Visual acuity of 20/40 or better was achieved in 38 (82.6%) eyes. Eleven eyes developed at least one complication, including cataract in eight eyes, glaucoma in eight eyes, subretinal neovascular membranes in two eyes, and subretinal fibrosis in one eye. Disease recurred during follow-up in 18 eyes. Development of complications was negatively associated with final visual acuity of 20/20 (P ¼ 0.0317). Shorter interval between symptoms and treatment was a predictor of final visual acuity of 20/20 (odds ratio ¼ 10.4; 95% confidence interval ¼ 1.61-67.3). Recurrence of inflammation was significantly associated with development of complications (P ¼ 0.003), worse visual acuity (P ¼ 0.022) and presence of posterior synechiae of the iris at presentation (P ¼ 0.0083), longer interval between symptoms and treatment (P ¼ 0.013), initial treatment with intravenous corticosteroids (P ¼ 0.0012), and rapid tapering of corticosteroids (P ¼ 0.0063). Conclusion Visual prognosis of VKH in children is generally favourable. Clinical findings at presentation, development of complications, interval between symptoms and treatment, recurrence of inflammation, use of intravenous corticosteroids, and method of tapering of systemic corticosteroids were significant prognostic factors.

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Section: Introductionmentioning

confidence: 99%

Vogt-Koyanagi-Harada disease in children

El‐Asrar

Alkharashi

Aldibhi

et al. 2007

Eye

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“…The age group most affected compromises people in their second to fifth decades of life and prevalence is even greater in the third decade. Children are rarely affected, but when they are the clinical course is more aggressive that in adult cases 6 . The youngest VKHS patient described was a 4-year-old child 1 .…”

Section: Introductionmentioning

confidence: 99%

Síndrome de Vogt-Koyanagi-Harada e o seu acometimento multissistêmico

Mota¹,

Santos²

2010

Rev. Assoc. Med. Bras.

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Vogt-Koyanagi-Harada's syndrome is a rare disease that affects tissues containing melanocytes, such as the eyes, central nervous system, inner ear and skin. Some ethnic groups have a higher probability of developing the disease, including Asians, Indians and Latin Americans and females are affected more often. Methods: Literature was reviewed in books, articles published on the internet and papers available in the online databases MEDLINE, LILACS and SciELO. Texts were selected that focused on otorhinolaryngological symptoms. Literature review: The disease probably has autoimmune etiology, with aggression occurring on the surface of melanocytes by promoting inflammatory reaction in which T lymphocytes predominate. The allele most often found in association with this disease is HLA DRB1*0405. Clinical manifestations are divided into four stages: prodromal, uveitic, chronic and recurrent. Otorhinolaryngological symptoms occur during the uveitic stage and are characterized by bilateral sensorineural hearing loss, tinnitus and vestibular symptoms. Diagnosis is made according to the diagnostic criteria for the disease. Treatment is primarily with corticosteroids. Conclusions: It is important that professionals in other specialties are able to recognize Vogt-Koyanagi-Harada's syndrome, because late diagnosis can lead to ocular and cutaneous sequelae.

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“…Glaucoma was a common complication and reported in 46% of the children with VKH in Tabbara's report [3]. In our patient, IOP was well controlled after laser iridotomy and antiglaucoma medication.…”

Section: Discussionmentioning

confidence: 48%

“…If these treatments fail, synechiolysis is recommended during cataract surgery. There is possible to improve aqueous outflow and trabecular function may be partially reversible [3].…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada disease in a 9-year-old girl

2015

J Coast Life Med

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Vogt‐Koyanagi‐Harada syndrome in children compared to adults

Cited by 89 publications

References 12 publications

Vogt-Koyanagi-Harada disease in children

Vogt-Koyanagi-Harada disease in children

Síndrome de Vogt-Koyanagi-Harada e o seu acometimento multissistêmico

Vogt-Koyanagi-Harada disease in a 9-year-old girl

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