Vogt–Koyanagi–Harada syndrome

Greco, Antonio; Fusconi, Massimo; Gallo, Andrea; Turchetta, Rosaria; Marinelli, C.; Macrì, Giulia; Virgilio, Armando De; Vincentiis, Marco de

doi:10.1016/j.autrev.2013.01.004

Cited by 121 publications

(92 citation statements)

References 59 publications

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“…Harada finally described a case with posterior uveitis, cerebrospinal pleocytosis, and an exudative retinal detachment in 1926. Since then these manifestations have been grouped together in what is known as VKH syndrome [1]. The disease follows a particular time course initially presenting in a prodromal phase with non-specific symptoms including fever, headache, vertigo, and dysacusis.…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Syndrome in a Healthy African-American Woman: Case Report and Review of Literature

Saraf¹

2015

Rheumatology (Sunnyvale)

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A previously healthy 18 year-old African-American female presented with unilateral vision loss associated with headaches. Initial ocular examination revealed an exudative retinal detachment involving the macula, disc edema, and choroidal striae worse in the right than the left eye. Fluorescein angiography showed multiple punctate hyperfluorescent lesions with leakage into the subretinal space. Extensive work up led to the diagnosis of VogtKoyanagi-Harada syndrome. The patient was treated with a prolonged taper of systemic prednisone and approximately 4 months after presentation, vision improved to 20/20 in the right eye and 20/25 in the left eye.

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Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Syndrome in a Healthy African-American Woman: Case Report and Review of Literature

Saraf¹

2015

Rheumatology (Sunnyvale)

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“…Some researchers have found out that the disease is more common at patients with genetic predisposition to the disease, including those from Asian, Hispanic, Middle Eastern and Native American populations [1,2]. The etiology of this disease is not well known, but an immune response to a human leukocyte antigen (HLA) is suspected.…”

Section: Introductionmentioning

confidence: 99%

The Light that Failed - In case of a Patient with Vogt-Koyanagi-Harada Disease

Emanuela¹

2014

Pharm Anal Acta

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Although it is not common, impairment of eye in autoimmune inflammatory diseases can become very severe by its evolution and complications. Often eye disorders within the autoimmune inflammatory diseases are not correctly diagnosed. These disorders are usually diagnosed as independent entities and thus local corrective treatment is the only applied. In these situations the evolution of uveitis can be toward blindness. The case presented by us unfortunately fits into this typology of local treatment with repeated surgical interventions without encouraging results. At time of diagnosis the patient completely loses sight in one eye and at the other it dropped to below 50%. In 1907 Rudyard Kipling got the Nobel Prize for his novel'' The Light That Failed'', whose main character lost view but from other reasons than our patient.

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“…The presence of extra-ocular symptoms varies in different ethnic groups. [2][3][4] The classic clinical course of VKHS can be divided into 4 clinical stages. [3] The prodromal phase is short (days) and resembles a viral infection, with non-specific symptoms as fever, nausea, headache and photophobia, and is associated with a lymphocytic pleocytosis of the cerebrospinal fluid (CSF).…”

Section: Introductionmentioning

confidence: 99%

“…methotrexate, azathioprine, cyclosporine, rituximab, adalimumab) is given in case of corticosteroid resistance or side effects. [1][2][3][4][10][11][12][13][14][15] Ocular complications linked to both disease activity and treatment may lead to permanent visual loss after extinction of the uveitic phase. [3,10] The visual prognosis of VKHS varies and depends mainly on early diagnosis and rapid appropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

Vogt-Koyanagi-Harada syndrome: Experience in a Belgian university hospital and review of the literature

Sels

Calster

Vanderschueren

et al. 2017

CRIM

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Introduction: The Vogt-Koyanagi-Harada syndrome (VKHS) is rare in Europe. Bilateral panuveitis is the defining characteristic, but the disease can affect other tissues containing melanin, such as the inner ear, the meninges, and the skin. Therefore, patients may present not only to ophthalmologists, but also to internists, dermatologists, ENT-physicians and neurologists. Early and aggressive immunosuppressive treatment is necessary in order to prevent permanent visual loss or systemic complications. Objective: We retrospectively studied 12 patients diagnosed and treated in a specialized uveitis clinic in Leuven (Belgium) between 2005 and 2013, and we compared our data with literature. Results:The most common extra-ocular manifestations were neurological, with headache (100%) and lymphocytic meningitis (75%) as main findings. Tinnitus was present in 50%, and vertigo in 42%. Vitiligo was the most frequent dermatological manifestation and present in 42%. Uveitis recurred in 67% of patients with 1 to 4 relapses per patient and a median time to recurrence of 6 months (range 1-11). Normal visual acuity was seen in 75% of patients at the end of follow-up (5 to 60 months), but 3 patients had at least some degree of permanent visual impairment in at least one eye. Conclusion: VKHS is a rare, multisystem disorder, characterized by bilateral uveitis and variable neurologic, auditory and skin symptoms. A lumbar puncture increases the diagnostic yield. A fast diagnosis allows timely initiation of adequate therapy, and If treated correctly, VKHS has a favorable prognosis. It is unclear if initial intravenous therapy improves frequency and time to remission.

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Vogt–Koyanagi–Harada syndrome

Cited by 121 publications

References 59 publications

Vogt-Koyanagi-Harada Syndrome in a Healthy African-American Woman: Case Report and Review of Literature

Vogt-Koyanagi-Harada Syndrome in a Healthy African-American Woman: Case Report and Review of Literature

The Light that Failed - In case of a Patient with Vogt-Koyanagi-Harada Disease

Vogt-Koyanagi-Harada syndrome: Experience in a Belgian university hospital and review of the literature

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