Vogt–Koyanagi–Harada<i>-like</i> Disease following Yellow Fever Vaccination

Campos, Wesley Ribeiro; Cenachi, Sarah P F; Soares, Matheus Schmidt; Gonçalves, Priscila Freitas; Vasconcelos-Santos, Daniel Vítor

doi:10.1080/09273948.2019.1661498

Cited by 33 publications

(27 citation statements)

References 6 publications

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“…Another case of uveitis ten days after yellow fever vaccination also showed a similar timing relationship. 4 The present patient experienced acute bilateral visual deterioration ten days after her third injection of the HPV4 vaccine without any prodromal symptoms or extraocular features. Multimodal imaging revealed retinal wrinkles, macular edema, optic disc swelling, and diffuse choroidal thickening in both eyes.…”

Section: Discussionmentioning

confidence: 56%

Resolution of Harada disease-like uveitis after quadrivalent human papillomavirus vaccination: a case report

Kong

Ding

2021

Human Vaccines & Immunotherapeutics

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This article describes a patient who developed Harada disease-like uveitis after quadrivalent human papillomavirus (HPV4) vaccination and experienced resolution without any systemic treatment. To achieve this aim, a case report and a review of related literature on HPV vaccination causing uveitis were conducted. The results of this study show a diagnosis of Harada disease-like uveitis after HPV4 vaccination based on the vaccination history, clinical symptoms, and multimodal imaging. Resolution without any systemic corticosteroid treatment was observed. According to these findings, patients may develop uveitis with Harada-like features, which can be a mild and self-limiting process, after HPV4 vaccination.

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Section: Discussionmentioning

confidence: 56%

Resolution of Harada disease-like uveitis after quadrivalent human papillomavirus vaccination: a case report

Kong

Ding

2021

Human Vaccines & Immunotherapeutics

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“…Our patient showed signs of reduced vision, noticed 5-6 weeks after vaccination. A YF vaccination-related, Vogt-Koyanagi-Harada-like disease has been recently reported [12]. Although there are some similarities between both cases, in our patient it was unclear when it first occurred, since the patient was long-term mechanically ventilated, had a tracheostoma which limited verbal communication, and suffered from delirium.…”

Section: Discussionmentioning

confidence: 69%

Severe Multiorgan Failure Following Yellow Fever Vaccination

et al. 2020

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Background: The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported. Case presentation: We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient required admission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five days after the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Three days later he sought medical attention and was transferred to the University Hospital Heidelberg with beginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia, and acute renal failure the same day. Within one week after vaccination, antibodies against YF virus were already detectable and progressively increased over the next two weeks. Viral RNA was detected in serum on the day of admission, with a viral load of 1.0 × 105 copies/mL. The YF virus (YFV) RNA was also present in tracheal secretions for several weeks and could be detected in urine samples up to 20 weeks after vaccination, with a peak viral load of 1.3 × 106 copies/mL. After 20 weeks in the ICU with nine weeks of mechanical ventilation, the patient was transferred to another hospital for further recovery. Conclusions: The risk for severe adverse events due to the YF vaccination should be balanced against the risk of acquiring a severe YF infection, especially in elderly travelers.

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“…VKH has been associated with various vaccines such as Hepatitis B, Hepatitis C, and yellow fever as well as a few biological drugs used in anti-cancer therapy. [ 9 ] This can be attributed to the immunogenetic dysregulation that can be caused by the latter. The etiology of the occurrence of autoimmune diseases post-vaccination is unclear.…”

Section: Discussionmentioning

confidence: 99%

Harada-like syndrome post-Covishield vaccination: A rare adverse effect

Reddy

Pandey²,

Ojha³

et al. 2021

Indian Journal of Ophthalmology

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Covishield is in wide use in India with about 80% efficacy. Serious side effects are still under study. A 30-year-old female presented to us 7 days post-vaccination with a 5-day history of sudden diminution of vision in both eyes. The clinical findings were suggestive of the Vogt-Koyanagi-Harada (VKH) syndrome. She was treated with high-dose oral steroids. At this juncture, the association was unclear. However, it was justified by an acute flare-up of uveitis on day 2 post the second dose of vaccination despite ongoing steroids. A direct correlation of Harada-like syndrome with the Covishield vaccine is observed here.

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Vogt–Koyanagi–Harada-like Disease following Yellow Fever Vaccination

Cited by 33 publications

References 6 publications

Resolution of Harada disease-like uveitis after quadrivalent human papillomavirus vaccination: a case report

Resolution of Harada disease-like uveitis after quadrivalent human papillomavirus vaccination: a case report

Severe Multiorgan Failure Following Yellow Fever Vaccination

Harada-like syndrome post-Covishield vaccination: A rare adverse effect

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