Vogt-Koyanagi-Harada Disease Associated with COVID-19 mRNA Vaccine

Koong, Lin Ru; Chee, Wai Kitt; Toh, Zhi Hong; Ng, Xin Le; Agrawal, Rupesh; Ho, Su Ling

doi:10.1080/09273948.2021.1974492

Cited by 50 publications

(37 citation statements)

References 8 publications

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“… 8 Both of these vaccines do not utilize an additional adjuvant. 8 , 14 Due to the similar phenotype of uveitis despite a different type of vaccine, antigen mimicry from the virus could be a potential trigger. In this case, additional aqueous humor analysis ruled out intraocular infection and demonstrated the inflammatory status, with prominent elevated IL-6.…”

Section: Discussionmentioning

confidence: 99%

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Acute-onset Vogt-Koyanagi-Harada like uveitis following Covid-19 inactivated virus vaccination

Chen

Wang

2022

American Journal of Ophthalmology Case Reports

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Purpose We report a case of a 19-year-old male who presented with bilateral Vogt-Koyanagi-Harada (VKH)-like panuveitis following an injection of an inactivated Covid-19 vaccine. Observations A 19-year-old male was referred to our clinic with a 2-week history of blurred vision on both eyes and headaches, 12 hours following the administration of the first dose of an inactivated Covid-19 virus vaccine (Sinovac). He denied any past ocular or medical history. Clinical examination and multimodal imaging tests identified serous retinal detachment and choroidal thickening posteriorly and deep yellow foci in the far peripheral retina. Aqueous humor analysis ruled out viral and bacterial infection including Covid-19, but demonstrated an elevated interleukin-6 level. A workup ruled out systemic infection or autoimmune disease. Although the patient received a single positive T-SPOT result, no other clinical evidence supported active tuberculosis infection. Non-infectious panuveitis was diagnosed and treated with periocular steroids that quickly resolved the serous retinal detachment. Conclusions and Importance This is the first report of VKH-like uveitis following an inactivated Covid-19 vaccine, with aqueous humor analysis ruling out viral or bacterial infection and demonstrating an elevated interleukin-6 level. Though rare, VKH-like uveitis may be associated with administration of an inactivated Covid-19 vaccine.

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Section: Discussionmentioning

confidence: 99%

“… 10 , 11 , 12 , 13 Recently, cases of VKH disease following Covid-19 mRNA and adenovirus vector vaccine have been reported. 14 We report a case of bilateral VKH-like disease following an inactivated Covid-19 virus vaccine.…”

Section: Introductionmentioning

confidence: 96%

Acute-onset Vogt-Koyanagi-Harada like uveitis following Covid-19 inactivated virus vaccination

Chen

Wang

2022

American Journal of Ophthalmology Case Reports

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“…There is a published report of two patients with bilateral thrombosis of the superior ophthalmic vein in addition to rare cases of cerebral venous sinus thrombosis and vaccine-induced immune thrombocytopenia with consequential orbital symptoms and signs of inflammation [ 39 – 41 ]. Investigations performed to confirm thrombosis include computed tomography (CT), angiography of the head and neck and magnetic resonance imaging (MRI) of the brain.…”

Section: Covid-19 Vaccine-associated Ocular Inflammationmentioning

confidence: 99%

“…Clinical examination and imaging investigations were consistent with and led to the diagnosis of Vogt-Koyanagi-Harada disease. After an initial course of high-dose intravenous methylprednisolone and subsequent oral prednisolone, the patient’s symptoms resolved [ 41 ].…”

Section: Covid-19 Vaccine-associated Ocular Inflammationmentioning

confidence: 99%

The Eye of the Storm: COVID-19 Vaccination and the Eye

Betzler

Ng³

et al. 2021

Ophthalmol Ther

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The COVID-19 pandemic has galvanized the global response towards the development of new vaccines based on novel technologies at an unprecedented pace. Since the widespread implementation of vaccination campaigns, case reports on vaccines' systemic side effects, including ocular manifestations, have emerged. Since administered vaccines are generally not able to cause the disease in the recipient, or induce an immune response against the pathogen, we hypothesize that the development of ocular phenomena post-COVID-19 vaccination may occur via an immune response elicited by the vaccine. Of many, the most common ocular adverse events include facial nerve palsy, central venous sinus thrombosis and acute anterior uveitis. These COVID-19 vaccine-induced ocular (CVIO) adverse events could resemble the ocular findings in some of the COVID-19 patients. This review will provide a comprehensive overview of published ocular side effects potentially associated with COVID-19 vaccination and serve as a springboard for further research into CVIO adverse events.

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“…Adding up to this list, a few cases of new-onset Vogt-Koyanagi-Harada (VKH) are reported worldwide to be associated with the COVID-19 vaccination. [ 5 6 7 ] A 30-year-old lady presented to our clinic with Harada-like symptoms suspiciously secondary to the COVID-19 vaccination, which was considered incidental at first but was justified later with the dramatic worsening of the symptoms and flare-up of uveitis immediately after the second dose. To the best of our knowledge, this is the first case of its kind in our country, and hence, assumes its significance in the literature.…”

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confidence: 99%

Harada-like syndrome post-Covishield vaccination: A rare adverse effect

Reddy

Pandey²,

Ojha³

et al. 2021

Indian Journal of Ophthalmology

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Covishield is in wide use in India with about 80% efficacy. Serious side effects are still under study. A 30-year-old female presented to us 7 days post-vaccination with a 5-day history of sudden diminution of vision in both eyes. The clinical findings were suggestive of the Vogt-Koyanagi-Harada (VKH) syndrome. She was treated with high-dose oral steroids. At this juncture, the association was unclear. However, it was justified by an acute flare-up of uveitis on day 2 post the second dose of vaccination despite ongoing steroids. A direct correlation of Harada-like syndrome with the Covishield vaccine is observed here.

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Vogt-Koyanagi-Harada Disease Associated with COVID-19 mRNA Vaccine

Cited by 50 publications

References 8 publications

Acute-onset Vogt-Koyanagi-Harada like uveitis following Covid-19 inactivated virus vaccination

Acute-onset Vogt-Koyanagi-Harada like uveitis following Covid-19 inactivated virus vaccination

The Eye of the Storm: COVID-19 Vaccination and the Eye

Harada-like syndrome post-Covishield vaccination: A rare adverse effect

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