This study examined the relationship between speech characteristics and psychopathology throughout the course of affective disturbances. Our sample comprised 20 depressive, hospitalized patients who had been selected according to the following criteria: (1) first admission; (2) long-term patient; (3) early entry into study; (4) late entry into study; (5) low scorer; (6) high scorer, and (7) distinct retarded-depressive symptomatology. Since our principal goal was to model the course of affective disturbances in terms of speech parameters, a total of 6 repeated measurements had been carried out over a 2-week period, including 3 different psychopathological instruments and speech recordings from automatic speech as well as from reading out loud. It turned out that neither applicability nor efficiency of single-parameter models depend in any way on the given, clinically defined subgroups. On the other hand, however, no significant differences between the clinically defined subgroups showed up with regard to basic speech parameters, except for the fact that low scorers seemed to take their time when producing utterances (this in contrast to all other patients who, on the average, had a considerably shorter recording time). As to the relationship between psychopathology and speech parameters over time, we found significant correlations: (1) in 60% of cases between the apathic syndrome and energy/dynamics; (2) in 50% of cases between the retarded-depressive syndrome and energy/dynamics; (3) in 45% of cases between the apathic syndrome and mean vocal pitch, and (4) in 71 % of low scores between the somatic-depressive syndrome and time duration of pauses. All in all, single parameter models turned out to cover only specific aspects of the individual courses of affective disturbances, thus speaking against a simple approach which applies in general.