Vocal fold botulinum toxin injection for refractory paradoxical vocal fold motion disorder

deSilva, Brad W.; Crenshaw, Drew; Matrka, Laura; Forrest, L. Arick

doi:10.1002/lary.27471

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…Improvement in VCD symptoms following the intervention was reported in three of the four studies. A reduction in dyspnoea symptoms was reported by de Silva et al 38 using the Dyspnea Index. 37 Baxter et al 38 reported participants in their study required an average of 3.85 injections ranging from 1 to 12 when followed for an average of 24 months.…”

Section: Botulinum Toxin Injectionsmentioning

confidence: 71%

“…7,38,41 This was evident in studies investigating the use of botulinum toxin injections where participants reported ongoing VCD symptoms following glottic airway and respiratory retraining. 7,33,38,41 The number of sessions attended was described as at least two 41 or when the participants had exhausted laryngeal control techniques. 38 Adherence to techniques was not reported.…”

Section: Treatment Resultsmentioning

confidence: 98%

“…7,33,38,41 The number of sessions attended was described as at least two 41 or when the participants had exhausted laryngeal control techniques. 38 Adherence to techniques was not reported. Three…”

Section: Treatment Resultsmentioning

confidence: 99%

“…Three of the four studies investigating outcomes following botulinum toxin injections 7,38,41 provided details about the administration technique, doses and average number of repeat botulinum toxin injections. A range of techniques was used including endoscopic guided transcutaneous injection, 7,41 transcutaneous electromyography (EMG) guided injection 7,38 and visually guided injection under a general anaesthetic. 7 Participants were treated with unilateral injections 7,41 and bilateral injections.…”

Section: Botulinum Toxin Injectionsmentioning

confidence: 99%

“…38 Doses of botulinum toxin varied across the studies from 2.5U, 7 5.0U 41 and a range of 1.7-5.5U. 38 Treatment results. Improvement in VCD symptoms following the intervention was reported in three of the four studies.…”

Section: Botulinum Toxin Injectionsmentioning

confidence: 99%

See 4 more Smart Citations

Treatment effectiveness for Vocal Cord Dysfunction in adults and adolescents: A systematic review

Mahoney

Hew

Vertigan

et al. 2021

Clin Experimental Allergy

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Objective: To determine whether treatment effectiveness can be established for a range of vocal cord dysfunction (VCD) interventions in adolescents and adults.Design: A systematic review of the literature and risk of bias appraisal was completed using the Joanna Briggs Institute Critical Appraisal Tools. Data were qualitatively synthesized in the broad intervention groups of glottic airway and respiratory retraining, pharmacological therapies, airway device therapies and psychological therapies.Data sources: Nine electronic databases, two clinical trial registries and the grey literature were searched from inception to September 2021 for articles on VCD interventions or equivalent terms.Eligibility criteria: Studies were included if they were randomized controlled trials, non-randomized controlled trials, quasi-experimental pre-and post-test studies and within-subject repeated measure designs, participants were 13 years or older, VCD was diagnosed using laryngoscopy or CT larynx, VCD intervention was provided and outcome measures reported on VCD symptoms. Results:The search yielded no randomized controlled trials. There were 17 quasiexperimental studies that met the eligibility criteria, and these studies reported on glottic airway and respiratory retraining, botulinum toxin injections, inspiratory muscle strength training and amitriptyline; all were associated with VCD symptom reduction. In addition, 2 within-subject repeated measure studies reported inspiratory muscle strength training and respiratory retraining to be effective in reducing symptoms in participants with exertional VCD. The included studies were reported in fulltext publications (11) and conference proceedings (8). There was a high risk of bias and low quality of evidence across all intervention areas. Conclusion: Glottic airway and respiratory retraining, botulinum toxin injections, lowdose amitriptyline and inspiratory muscle strength training devices have been associated with symptom reduction in adults and adolescents with vocal cord dysfunction. Limited objective data exist to support the effectiveness of these interventions, and robust controlled trials are needed in this area.

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Section: Botulinum Toxin Injectionsmentioning

confidence: 71%