VNS for Treatment of Inflammatory Joint Diseases

Levine, Yaakov A.; Simon, Jesse; Koopman, Frieda A.; Faltys, Michael; Zitnik, Ralph; Tak, Paul‐Peter

doi:10.1007/978-3-319-28612-9_2

Cited by 4 publications

(2 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although not yet validated as a tool for monitoring the activity of the inflammatory reflex specifically, the potential of HRV as a biomarker for stimulation of the inflammatory reflex has been discussed [ 85 ]. Interestingly, HRV measurements were proposed not only for the detection of autonomic dysfunction, but also as predictors of increased proinflammatory status in the elderly population [ 3 ].…”

Section: Ans Imbalance and Inflammaging In The Heart: Focus On Heart ...mentioning

confidence: 99%

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Giunta,

Xia,

Pelliccioni

et al. 2023

GeroScience

View full text Add to dashboard Cite

Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently recognized as the main risk factor for development and progression of the most common age-related diseases (ARDs). Extensive investigations were focused on a plethora of proinflammatory stimuli that can fuel inflammaging, underestimating and partly neglecting important endogenous anti-inflammaging mechanisms that could play a crucial role in such age-related proinflammatory state. Studies on autonomic nervous system (ANS) functions during aging highlighted an imbalance toward an overactive sympathetic nervous system (SNS) tone, promoting proinflammatory conditions, and a diminished parasympathetic nervous system (PNS) activity, playing anti-inflammatory effects mediated by the so called cholinergic anti-inflammatory pathway (CAP). At the molecular level, CAP is characterized by signals communicated via the vagus nerve (with the possible involvement of the splenic nerves) through acetylcholine release to downregulate the inflammatory actions of macrophages, key players of inflammaging. Notably, decreased vagal function and increased burden of activated/senescent macrophages (macrophaging) probably precede the development of several age-related risk factors and diseases, while increased vagal function and reduced macrophaging could be associated with relevant reduction of risk profiles. Hypothalamic–pituitary–adrenal axis (HPA axis) is another pathway related to ANS promoting some anti-inflammatory response mainly through increased cortisol levels. In this perspective review, we highlighted that CAP and HPA, representing broadly “anti-inflammaging” mechanisms, have a reduced efficacy and lose effectiveness in aged people, a phenomenon that could contribute to fuel inflammaging. In this framework, strategies aimed to re-balance PNS/SNS activities could be explored to modulate systemic inflammaging especially at an early subclinical stage, thus increasing the chances to reach the extreme limit of human lifespan in healthy status.

show abstract

Section: Ans Imbalance and Inflammaging In The Heart: Focus On Heart ...mentioning

confidence: 99%

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Giunta,

Xia,

Pelliccioni

et al. 2023

GeroScience

View full text Add to dashboard Cite

show abstract

“…These types of HRV analyses have shown correlations between reduced vagus nerve tone with serum c-reactive protein levels and disease activity in RA (Evrengul 2004;Sajadieh et al 2004;Koopman et al 2016b). Although not yet validated as a tool for monitoring the activity of the inflammatory reflex specifically, the potential of HRV as a biomarker for closed-loop stimulation of the inflammatory reflex has been discussed elsewhere (Levine et al 2017).…”

Section: Biomarkersmentioning

confidence: 99%

Harnessing the Inflammatory Reflex for the Treatment of Inflammation-Mediated Diseases

Levine

Faltys

Chernoff

2019

Cold Spring Harb Perspect Med

Self Cite

View full text Add to dashboard Cite

Gentle Patterning Approaches toward Compatibility with Bio‐Organic Materials and Their Environmental Aspects

Grebenko

Motovilov

Bubis

et al. 2022

Small

View full text Add to dashboard Cite

Advances in material science, bio-electronic, and implantable medicine combined with recent requests for eco-friendly materials and technologies inevitably formulate new challenges for nano-and micro-patterning techniques. Overall, the importance of creating micro and nanostructures is motivated by a large manifold of fundamental and applied properties accessible only at the nanoscale. Lithography is a crucial family of fabrication methods to create prototypes and produce devices on an industrial scale. The pure trend in the miniaturization of critical electronic semiconducting components is recently enhanced by implementing bio-organic systems in electronics. So far, significant efforts have been made to find novel lithographic approaches and develop old ones to reach compatibility with delicate bio-organic systems and minimize the impact on the environment. Herein, we briefly review such delicate materials and sophisticated patterning techniques.

show abstract

VNS for Treatment of Inflammatory Joint Diseases

Cited by 4 publications

References 60 publications

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Harnessing the Inflammatory Reflex for the Treatment of Inflammation-Mediated Diseases

Gentle Patterning Approaches toward Compatibility with Bio‐Organic Materials and Their Environmental Aspects

Contact Info

Product

Resources

About