VLDL, Apolipoproteins B, CIII, and E, and Risk of Recurrent Coronary Events in the Cholesterol and Recurrent Events (CARE) Trial

Abstract

The plasma concentrations of VLDL particles and apoCIII in VLDL and LDL are more specific measures of coronary heart disease risk than plasma triglycerides perhaps because their known metabolic properties link them more closely to atherosclerosis.

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase

“…Similarly, genetic alterations in LPL hydrolytic activity are also associated with atherosclerosis (45). Of note, in the CARE trial, coronary heart disease risk was associated with plasma TRL levels only if combined with increased levels of the LPL inhibitor ApoCIII (46). Our data would predict that impaired LPL enzymatic activity (for example, in diseases like diabetes) might decrease endogenous PPAR␣ activation and its subsequent downstream effects, including antiinflammatory responses.…”

Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein

“…Increased concentrations of LDL(Ϫ) have been associated with pro-inflammatory conditions such as familial hyperlipidemia, diabetes, and hemodialysis, with levels up to 20% of total LDL found in some subjects (10,13). Interestingly, many of these clinical conditions are also characterized by dysfunctional LPL (35,36). One recent study found that only the LDL content of the LPL inhibitor apolipoprotein CIII independently predicted cardiovascular events, whereas total LDL concentration did not (35).…”

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

“…Apolipoprotein (apo) C-III has been shown to be an independent predictor of recurrent coronary events (Sacks et al, 2000) and a powerful, significant marker of prevalent coronary heart disease (CHD) in men, independent of lowdensity lipoprotein (LDL)-cholesterol (C) and high-density lipoprotein (HDL)-C (Onat et al, 2003). These associations may reflect the important role played by apoC-III in regulating the metabolism of plasma triglyceride-rich lipoproteins (TRL).…”