Vladimir Alexandrovich Engelhardt 1894–1984

A history of research on yeasts 9: regulation of sugar metabolism1

“…Mutations within both these genes have pleiotropic effects and, having first been identified by virtue of such different effects, these mutants have been given several synonymous designations, which are listed in Table 13. Cyc8p and Tup1p, physically associated within a large nuclear protein complex [383], interfere with chromatin structure [92] and both of them act as mediator proteins for other regulatory proteins, which explains their pleiotropic effects (for review, see [328]).…”