The edition of Augustine’s City of God by the Spanish-born humanist Juan Luis Vives (first published in 1522) is one of most successful pieces of patristic scholarship of the sixteenth century. Produced just before the explosive escalation of the Reformation, it remained the key version of the text for over a hundred years. This article analyses the presentation of patristic knowledge in Vives’ commentary to explore how the confessional conflicts affected patristic scholarship. It argues that Vives’ work survived the confessional pressures relatively unscathed because it made Augustine’s work manageable and accessible across confessional parties. In doing so it seeks to highlight the importance of confessional silence in the Republic of Letters as a strategy to confront the pressures of confessionalisation.