Vitreous surgery in patients with primary neuropathic amyloidosis

Sandgren, Ola; Stenkula, Staffan; Dedorsson, Inger

doi:10.1111/j.1755-3768.1985.tb01549.x

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…The results are remarkable, with a marked increase in visual acuity, if no other eye diseases exist 8,11,18 as we could corroborate in our study. However, most authors refer a recurrence after several years of follow-up, with new deposition of amyloid in the vitreous cavity, leading to a decrease in visual acuity and need for a new vitrectomy.…”

Section: Discussionsupporting

confidence: 87%

“…However, most authors refer a recurrence after several years of follow-up, with new deposition of amyloid in the vitreous cavity, leading to a decrease in visual acuity and need for a new vitrectomy. 8,18,[25][26][27][28][29] Results of out study confirmed that vitrectomy is a safe and useful treatment for vitreous opacities in patients with FAP-I. No complications of vitrectomy (retinal detachment, retinal tear, cataract, and glaucoma) were observed.…”

Section: Discussionsupporting

confidence: 53%

“…17 In fact, this surgery has remarkably good immediate results, improving visual acuity, and complications are rare. 8,18 However, some patients experience a decrease in visual acuity associated with further amyloid deposition in the visual axis and need surgical reintervention. It is known that each vitrectomy increases the surgical and anesthetic risks for the patient 19 and also raises the cost of treatment for patients with FAP.…”

mentioning

confidence: 99%

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Recurrence of Vitreous Amyloidosis and Need of Surgical Reintervention in Portuguese Patients With Familial Amyloidosis Attr V30m

Beirão

Matos²,

Beirão³

et al. 2011

Retina

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

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Recurrence of Vitreous Amyloidosis and Need of Surgical Reintervention in Portuguese Patients With Familial Amyloidosis Attr V30m

Beirão

Matos²,

Beirão³

et al. 2011

Retina

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“…The symptoms presented by patients are floaters and, later, decreased vision. The clinical course and the results of vitrectomy have been subject to numerous reports (Sandgren et al. 1985; Doft et al.…”

Section: Discussionmentioning

confidence: 99%

Ocular manifestations in liver transplant recipients with familial amyloid polyneuropathy

Sandgren

Kjellgren

Suhr

2008

Acta Ophthalmologica

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. Purpose: To evaluate postoperative ocular involvement in Swedish liver transplant (LT) recipients with familial amyloid polyneuropathy (FAP). Methods: Routine ophthalmological examinations were performed in 48 LT recipients, with particular attention given to amyloid deposition in the anterior segment and the vitreous body. Medical records were scrutinized for information regarding neurological impairment at the time of the LT. The diagnosis was secured in all cases by examining for amyloid deposits in biopsy specimens and positive genetic testing for amyloidogenic transthyretin (ATTR) Val30Met mutation. Results: Six patients (12.5%) developed vitreous opacities within the post‐LT observation period. The first opacities were seen 40 months after transplantation, 8 years after the onset of systemic disease. Four patients (8%) developed secondary glaucoma, the first of which was observed 18 months after the procedure and 6.5 years after the onset of disease. Sixteen patients (33%) developed deposits on the anterior surface of the lens. Scalloped pupillary margins were noted in 10 patients (21%). Conclusion: The prevalence of eye complications increases with time after LT and regular follow‐up is necessary, especially to disclose the development of glaucoma – a complication with insidious symptoms of which patients are normally unaware.

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“…Vitreous veils typically occur in FAP patients as ‘glass wool’ opacifications and usually cause only marginal visual impairment. The vitreous veils probably represent transthyretin deposits synthesised by the retinal pigment epithelium and visual acuity usually returns to normal when clear imaging conditions are restored by vitrectomy 7. In our patient, the unilateral vitreous opacities (figure 1C), could not explain the complete loss of light perception, and vitrectomy was not performed.…”

Section: Discussionmentioning

confidence: 61%

Bilateral optic neuropathy in a patient with familial amyloidotic polyneuropathy

Hamann¹,

Jensen

Fledelius

2013

BMJ Case Reports

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Amyloidogenic transthyretin (ATTR)-related familial amyloidotic polyneuropathy (FAP) is an autosomal-dominant hereditary disease characterised by slowly progressive peripheral sensorimotor and autonomic neuropathy and tissue involvement of the heart, kidneys and central nervous system. Secondary glaucoma has been reported following intraocular surgery, but optic nerve involvement unrelated to glaucoma has not previously been described. We reported a male patient in his late 40s when deceased, who previously had a liver transplant in order to reduce the abnormal protein synthesis underlying his FAP ATTR Val30Met mutation. After 11 years of ophthalmic follow-up best-corrected visual acuity was 20/100 in his seeing eye, which further had visual field findings suggestive of optic neuropathy. This was also the diagnosis underlying the preceding insidious full loss of vision in the fellow eye, with colour Doppler imaging to support an ischaemic aetiology. To our knowledge, this is the first report of ischaemic optic neuropathy in this familial amyloid disorder.

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Vitreous surgery in patients with primary neuropathic amyloidosis

Abstract: Pars plana vitrectomy was performed in 9 patients from the north of Sweden because of amyloid deposits of the vitreous. Operative technique and post-operative results are presented.

Cited by 12 publications

References 9 publications

Recurrence of Vitreous Amyloidosis and Need of Surgical Reintervention in Portuguese Patients With Familial Amyloidosis Attr V30m

Recurrence of Vitreous Amyloidosis and Need of Surgical Reintervention in Portuguese Patients With Familial Amyloidosis Attr V30m

Ocular manifestations in liver transplant recipients with familial amyloid polyneuropathy

Bilateral optic neuropathy in a patient with familial amyloidotic polyneuropathy

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