Vitreous surgery for macular hole-related retinal detachment after phacoemulsification cataract extraction: 10-year retrospective review

Zheng, Qian; Yang, Shixin; Zhang, Y; Wu, Ronghan; Pang, Ji; Li, W

doi:10.1038/eye.2012.87

Cited by 16 publications

(12 citation statements)

References 45 publications

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“…Despite the clinical success of IOLs, they have numerous limitations and potential complications, including IOL dislocation, suboptimal biocompatibility, inadequate accommodation, and poor visual outcomes. In the worst cases, irreversible blindness may result 21 . Thus, a new strategy for treating congenital cataracts using naturally regenerated lenses is highly desirable.…”

Section: Discussionmentioning

confidence: 99%

Lens regeneration using endogenous stem cells with gain of visual function

Lin¹,

Ouyang²,

Zhu

et al. 2016

Nature

177

135

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The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We design a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells.

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Section: Discussionmentioning

confidence: 99%

Lens regeneration using endogenous stem cells with gain of visual function

Lin¹,

Ouyang²,

Zhu

et al. 2016

Nature

177

135

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“…2,3,12 Many surgical techniques such as macular buckling and retinopexy with cryotherapy, diathermy or photocoagulation, PPV with temporary tamponade, and simplified gas injection have been attempted for the A, B). 19 Recent studies show that PPV with ILM peeling and primary silicone oil tamponade had a high retinal reattachment without any restriction of postoperative patient position and significantly improved postoperative BCVA. Macular hole closure was confirmed on optical coherence tomography (D).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Retinal Detachment Secondary to Macular Hole in Highly Myopic Eyes

Wei

Li³

et al. 2014

Retina

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“…Macular hole retinal detachment (MHRD) is a specific condition related to myopia, especially when posterior staphyloma is present, and is thought to be caused by tangential tractional force between the vitreous and the retina [1 -3]. This rare event has also been described in highly myopic eyes following phacoemulsification and IOL (intraocular lens) implantation, further suggesting the role of the vitreoretinal interface in the pathogenesis of this complication [4]. Vitrectomy with internal limiting membrane (ILM) peeling has been shown to be an effective procedure to relieve macular traction over the detached retina, allowing successful treatment of RD induced by MH in highly myopic eyes [5].…”

Section: Introductionmentioning

confidence: 99%