Abstract:Purpose: This work subclassifies retinoblastoma vitreous seeds and evaluates the efficacy, regression patterns, and adverse effects of combination intravitreal melphalan and topotecan chemotherapy for resistant and recurrent vitreous seeds. Methods: A retrospective review of medical records was conducted of patients with retinoblastoma and resistant or recurrent vitreous seeds who were treated with intravitreal melphalan and topotecan injections from August 2014 to July 2018. Main outcome measures included reg… Show more
“…Some outstanding challenges in the analysis of outcomes continuing to confront the ocular oncologists are a lack of uniformity in employing classification systems, and the need to expand the one related to vitreous seeds. [ 6 ]…”
“…Some outstanding challenges in the analysis of outcomes continuing to confront the ocular oncologists are a lack of uniformity in employing classification systems, and the need to expand the one related to vitreous seeds. [ 6 ]…”
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