Vitreous opacities in infants born full-term and preterm by handheld swept-source optical coherence tomography

Scoville, N. Maxwell; Legocki, Alex T.; Touch, Phanith; Ding, Leona; Moshiri, Yasman; Bays-Muchmore, Coral; Qiao, Erica; Zhou, Kanheng; Zhong, Junping; Tarczy-Hornoch, Kristina; Wang, Ke; Cabrera, Michelle T.

doi:10.1016/j.jaapos.2021.09.007

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…Separately, Scoville et al observed punctate hyperreflective vitreous opacities in newborns, noting them to appear with higher density in premature infants. Investigations by Legocki et al and Scoville et al have drawn associations between presence of these opacities and ROP severity according to zone, stage, plus disease, and Type I ROP [47,49].…”

Section: Identification Of Novel Biomarkers Of Diseasementioning

confidence: 98%

Implementation of optical coherence tomography in retinopathy of prematurity screening

Hanif,

Jian,

Young

et al. 2024

Current Opinion in Ophthalmology

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Purpose of review In this review, we explore the investigational applications of optical coherence tomography (OCT) in retinopathy of prematurity (ROP), the insights they have delivered thus far, and key milestones for its integration into the standard of care. Recent findings While OCT has been widely integrated into clinical management of common retinal diseases, its use in pediatric contexts has been undermined by limitations in ergonomics, image acquisition time, and field of view. Recently, investigational handheld OCT devices have been reported with advancements including ultra-widefield view, noncontact use, and high-speed image capture permitting real-time en face visualization. These developments are compelling for OCT as a more objective alternative with reduced neonatal stress compared to indirect ophthalmoscopy and/or fundus photography as a means of classifying and monitoring ROP. Summary OCT may become a viable modality in management of ROP. Ongoing innovation surrounding handheld devices should aim to optimize patient comfort and image resolution in the retinal periphery. Future clinical investigations may seek to objectively characterize features of peripheral stage and explore novel biomarkers of disease activity.

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Section: Identification Of Novel Biomarkers Of Diseasementioning

confidence: 98%

Implementation of optical coherence tomography in retinopathy of prematurity screening

Hanif,

Jian,

Young

et al. 2024

Current Opinion in Ophthalmology

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“…However, it is speculated that these opacities could represent blood, protein, white blood cells, or retinal astrocyte precursors that are shed from the ROP ridge in advanced ROP ( 12 ). In cases of persistent fetal vasculature, the opacities may represent blood or other vascular remnants ( 12 , 28 ).…”

Section: Vitreous Biomarkersmentioning

confidence: 99%

“…Opacity density also increased with ROP severity based on stage at particular time points, suggesting that this finding could be used as an ROP severity biomarker in real time ( 12 ). Scoville et al went on to identify punctate hyperreflective vitreous opacities in 25 of 28 (89%) healthy full-term newborns, similar to 41 of 50 (82%) premature infants, using an investigational handheld SS-OCT device from the University of Washington ( 28 ). That study identified a much higher density of vitreous opacities in premature infants compared to full term newborns ( 28 ).…”

Section: Vitreous Biomarkersmentioning

confidence: 99%

“…Scoville et al went on to identify punctate hyperreflective vitreous opacities in 25 of 28 (89%) healthy full-term newborns, similar to 41 of 50 (82%) premature infants, using an investigational handheld SS-OCT device from the University of Washington ( 28 ). That study identified a much higher density of vitreous opacities in premature infants compared to full term newborns ( 28 ). This newer device confirmed an association between punctate hyperreflective vitreous opacity density and clinical ROP severity based on zone and stage ( 28 ).…”

Section: Vitreous Biomarkersmentioning

confidence: 99%

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Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review

Kubsad,

Ohan,

et al. 2023

Front. Pediatr.

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Retinopathy of prematurity (ROP) is caused by abnormal retinal vascularization in premature infants that has the potential for severe long-term vision impairment. Recent advancements in handheld optical coherence tomography (OCT) have enabled noninvasive, high-resolution, cross-sectional imaging of the infant eye at the bedside. The use of handheld OCT devices in the diagnosis of ROP in premature infants has furthered our understanding of disease state and progression. This review discusses the known and novel biomarkers of ROP severity in premature infants identified through handheld OCT and potential for future directions.

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“…The HH-OCT is widely used nowadays for pediatric ocular conditions. HH-OCT/OCT-A systems can reliably visualize and measure vitreous opacities and bands, perifoveal vessels, the macular shape, anterior chamber features, retinal tumors, and ganglion cell complex (GCC)/IPL/RNFL thickness in both premature and full-term infants (120)(121)(122)(123)(124)(125)(126)(127)(128)(129)(130). Hence, they are useful in conditions, such as congenital and pediatric glaucoma, macular edema, macular hole, epiretinal membrane, retinoschisis, retinal dystrophies, and other conditions (128,129,(131)(132)(133).…”

Section: Handheld Optical Coherence Tomographymentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

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The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.

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Vitreous opacities in infants born full-term and preterm by handheld swept-source optical coherence tomography

Cited by 5 publications

References 21 publications

Implementation of optical coherence tomography in retinopathy of prematurity screening

Implementation of optical coherence tomography in retinopathy of prematurity screening

Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

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