Vitreous humour as an alternative material for the determination of alcohol concentration in human corpses

Szeremeta, Michał; Mironiuk, Ewelina; Janica, Maciej; Drobuliakova, Petra; Lomperta, Karolina; Szczypek, Magdalena; Niemcunowicz‐Janica, Anna

doi:10.5114/amsik.2018.77923

Cited by 3 publications

(2 citation statements)

References 21 publications

(41 reference statements)

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“…The results show that in 23 of 31 analyzed specimens (74%) ethanol concentration in vitreous humor was slightly higher than in blood, according to the previous study [ 23 ] The BAC exceeded VAC in eight cases (26%).…”

Section: Resultssupporting

confidence: 58%

“…In this work, following our previous work on whole blood and non-conventional matrices [16][17][18][19][20][21] was validated a new, fast, high-throughput, and reproducible GC-FID assay for the evaluation of the ethanol concentration in blood and vitreous humor. The purpose was to highlight that the new method is a valid and validated alternative to other procedures, confirming the correlation between these different specimens, as reported in literature [22][23][24][25], that allow estimating blood alcohol concentrations when blood is unavailable or contaminated or in cases where blood analysis cannot be carried out.…”

Section: Introductionsupporting

confidence: 71%

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Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

et al. 2020

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Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical and forensic toxicology. Based on several reports, excessive alcohol consumption is the main contributing factor in traffic accidents, drownings, suicides, and other crimes. For these reasons, it becomes essential to analyze the alcohol concentration during autopsy. Although blood is usually used for alcohol analysis in post-mortem cases, it could suffer alterations, putrefaction, and microbial contaminations. As an alternative to whole blood, vitreous humor has been successfully used in medico-legal studies. In this work, post-mortem specimens were analyzed for ethanol determination. The analysis of blood and vitreous humor were carried-out using gas chromatography-flame ionized detector (GC-FID) with a total run time of 6 min. The method was validated in terms of limit of detection, limit of quantification, dynamic range, sensibility, recovery, precision and trueness. A linear regression analysis indicated a coefficient of determination (R2) of 0.9981. The study confirmed no statistically differences between alcohol concentration in blood and vitreous humor, leading vitreous humor as an excellent matrix that could be used as an alternative to whole blood in toxicological analysis in cases where blood is not available.

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Section: Resultssupporting

confidence: 58%

Section: Introductionsupporting

confidence: 71%

Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

et al. 2020

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Keep an eye on the crime – a new look at the forensic use of post-mortem eye examination to estimate time of death

Veer

Rzepczyk²,

Żaba³

2023

JMS

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Determining the time of death plays a crucial role in a forensic post-mortem examination. Many methods for the time of death (TOD) determination have been developed. However, most are not applicable during the first hours after death and produce large post-mortem interval (PMI) ranges. Eye examination makes it possible to precisely determine the time of death during the initial period after death with half-hour accuracy.. In recent years methods for estimating the time of death by measuring the changes in the eye have made great strides. Those methods use the changes in the reaction to drugs and macroscopically visible morphological changes. Experimental studies also produced equations that can estimate the post-mortem interval using biochemical, electrochemical and thermal changes within the eye.

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Interpretation of Ethanol Concentration Changes in Postmortem Blood and Vitreous Samples During Six Months of Refrigerated Storage

Maletin,

Vapa,

Radosavkic

et al. 2024

International J. of Pharmacology

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Vitreous humour as an alternative material for the determination of alcohol concentration in human corpses

Cited by 3 publications

References 21 publications

Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

Ethanol Determination in Post-Mortem Samples: Correlation between Blood and Vitreous Humor Concentration

Keep an eye on the crime – a new look at the forensic use of post-mortem eye examination to estimate time of death

Interpretation of Ethanol Concentration Changes in Postmortem Blood and Vitreous Samples During Six Months of Refrigerated Storage

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