Vitreous Fluorophotometry in Juvenile Diabetics After Oral Fluorescein

Nuzzi, Giuseppe; Vanelli, Maurizio; Venturini, Ivan; Bonacini, Mirca; Boselli, E

doi:10.1001/archopht.1986.01050230068034

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…This result is consistent with that of a pilot study previously carried out by us with the same technique (Nuzzi et al 1986). …”

Section: Discussionsupporting

confidence: 93%

“…In a previous open study on diabetics (Nuzzi et al, 1986) Bendazac decreased the VPC value by 25% (SD = 0.23). For this study the sample size was calculated so that a VPC change of at least 25% in the Bendazac group versus 10% in the Placebo group would allow a type I error of 5%, and a power (1 -p) of 80%.…”

Section: Sample Sizementioning

confidence: 78%

“…Convincing evidence has been presented by several groups (Cunha-Vaz et al 1979;Roy et al 1989;Abreu et al 1994) and by us (Nuzzi et al 1986(Nuzzi et al , 1988) that the diffusion of fluorescein into the vitreous, numerically expressed by the VPC, is modulated by the blood-ocular barrier. Less clear is the relationship of the VPC to the presence and severity of diabetic retinopathy.…”

Section: Discussionmentioning

confidence: 91%

“…With this method a breakdown of the BRB was demonstrated in diabetics with or without ophthalmoscopic signs of retinopathy (Cunha Vaz et al 1979;Nuzzi et al 1986;Abreu et al 1994).…”

mentioning

confidence: 99%

“…itreous fluorophotometry (VFPM) V offers a quantitative measurement of the permeability of the blood-retinal barrier (BRB) by evaluating the vitreous fluorescence after intravenous injection (Cunha Vaz et al 1975;Waltman et al 1978) or oral administration (Nuzzi et al 1986) of sodium fluorescein. With this method a breakdown of the BRB was demonstrated in diabetics with or without ophthalmoscopic signs of retinopathy (Cunha Vaz et al 1979;Nuzzi et al 1986;Abreu et al 1994).…”

mentioning

confidence: 99%

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Vitreous fluorophotometry and changes in blood‐retinal barrier permeability induced by Bendazac lysine

Nuzzi

Venturini

Gregorio

et al. 1997

Acta Ophthalmologica Scandinavica

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ABSTRACT. Vitreous fluorophotometry was used to investigate the effect of Bendazac lysine on the blood retinal barrier in 12 insulin-dependent diabetics with mild background retinopathy. The study was a randomized, double blind, cross-over trial, drug versus Placebo. Each treatment period was of 4 months. The vitreous penetration coefficient was reduced by 21% (95% c.i. 12, 30; p = 0.001) by treatment with respect to Placebo.Key words: insulin dependent diabetes -vitreous fluorophotometry -blood-retinal barrier -Bendazac lysine -Placebo -cross-over study.Acta Ophthalmol. Scand. 1997: 75: 41 -43 itreous fluorophotometry (VFPM)

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“…This result is consistent with that of a pilot study previously carried out by us with the same technique (Nuzzi et al 1986). …”

Section: Discussionsupporting

confidence: 93%

Section: Sample Sizementioning

confidence: 78%

Section: Discussionmentioning

confidence: 91%

“…With this method a breakdown of the BRB was demonstrated in diabetics with or without ophthalmoscopic signs of retinopathy (Cunha Vaz et al 1979;Nuzzi et al 1986;Abreu et al 1994).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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