Vitreous and Vision Degrading Myodesopsia

Sebag, J.

doi:10.1016/j.preteyeres.2020.100847

Cited by 61 publications

(68 citation statements)

References 341 publications

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“…Interestingly, the mean days from onset to surgery in the elderly group was significantly longer than in the young group. Possible factors delaying diagnosis in elderly patients with RRD include vitreous gel liquefaction [23], impaired macular function [24] and the presence of cataract [25]. Furthermore, the…”

Section: Discussionmentioning

confidence: 99%

Micro-incision vitrectomy surgery for primary rhegmatogenous retinal detachments with posterior vitreous detachments in elderly patients: Preoperative characteristics and surgical outcomes

et al. 2021

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Purpose To assess the preoperative characteristics and surgical outcomes of using micro-incision vitrectomy surgery (MIVS) to treat RRD with posterior vitreous detachment (PVD) in an older and a younger patient group. Methods This retrospective cohort study included 407 eyes from 397 patients with primary RRD with PVD who were consecutively treated in our hospital from February 2016 to February 2020. PVD was diagnosed clinically by the presence of a Weiss ring, or was diagnosed morphologically via optical coherence tomography and subsequently confirmed during surgery. The main outcome measures were preoperative RRD characteristics, best-corrected visual acuity (BCVA), and postoperative complications. Results Data were analysed from 55 eyes in the elderly group (age 70 and older), and 352 eyes in the young group (age 69 and younger). There was no significant inter-group difference in the initial reattachment rate. Preoperative characteristics indicated that elderly patients had a significantly lower rate of phakic eyes, shorter mean axial length, lower lattice incidence, and longer time spans from onset to surgery. There were no significant between-group differences in the incidence of the following complications: fibrin formation, intraocular pressure elevation, epi-retinal membrane on the macula, intraocular lens optic capture, proliferative vitreoretinopathy, and vitreous haemorrhage. While the elderly patients had significant postoperative improvements in BCVA, these improvements were significantly lower than those of the younger patients. Conclusions This study highlighted the characteristics and surgical outcomes of MIVS in elderly patients with RRD. Although the time from onset to surgery was longer, MIVS still can be performed safely to improve older patients’ postoperative BCVA.

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Section: Discussionmentioning

confidence: 99%

Micro-incision vitrectomy surgery for primary rhegmatogenous retinal detachments with posterior vitreous detachments in elderly patients: Preoperative characteristics and surgical outcomes

et al. 2021

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“…Myopia, especially high myopia, is associated with vitreous liquefaction, PVD, and lattice degeneration (35)(36)(37). As myopia alters collagen and hyaluronan association causing gel liquefaction and fibrous degeneration (38), abnormal vitreous liquefaction, and PVD occur earlier than normal. Compared with non-high myopic eyes, myopic eyes are prone to have asymmetrical PVDs, multiple PVDs, and multilayered PVDs (37,39).…”

Section: Discussionmentioning

confidence: 99%

Refractive Error and Eye Health: An Umbrella Review of Meta-Analyses

et al. 2021

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Purpose: To explore the associations between refractive errors and multiple eye health outcomes.Methods: This is an umbrella review based on systematic reviews with meta-analyses. In our study, refractive errors included myopia, hyperopia, astigmatism, and anisometropia. We reconducted the meta-analyses whose primary data were available in sufficient detail by random effect model. Heterogeneity was assessed by I2. The main outcomes included myopic macular degeneration (MMD), retinal detachment (RD), cataract, open-angle glaucoma (OAG), strabismus, age-related macular degeneration (AMD), and diabetic retinopathy (DR).Results: Myopia was associated with increased risk of MMD (relative risk = 102.11, 95% CI 52.6–198.22), RD (3.45, 1.08–11.00), nuclear cataract (2.15, 1.53–3.03), posterior subcapsular (PSC) cataract (1.74, 1.41–2.15), OAG (1.95, 1.74–2.19), exotropia (5.23, 2.26–12.09), but decreased risk of DR (0.83, 0.66–1.04), and early AMD (0.80, 0.67–0.94). From mild-to-high myopia, the association strengthened for MMD, RD, nuclear cataract, PSC cataract, OAG, and DR. Hyperopia was associated with an increased risk of early AMD (1.09, 1.01–1.18) and esotropia (22.94, 10.20–51.62). Astigmatism and anisometropia were associated with increased risk of both exotropia and esotropia.Conclusions: Myopia, especially high myopia, demonstrated the highest risk for eye health outcomes, such as MMD, RD, OAG, nuclear and PSC cataracts, and exotropia. However, myopia was associated with a lower risk of early AMD and DR. Individuals with hyperopia are more likely to suffer early AMD and esotropia. Astigmatism and anisometropia predispose to strabismus. A lot of research studies on the mechanism of the associations are needed.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=239744; identifier: 239744

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“… 8 , 9 Consequently, vitreous structure becomes more heterogeneous with the formation of liquefied pockets called lacunae and aggregation of collagen fibrils into larger fibers that present clinically as opacities, which cause the disturbing visual phenomenon of “floaters.” 4 , 10 Fibrous vitreous liquefaction not only introduces structural heterogeneity, but also promotes posterior vitreous detachment (PVD), a common cause of increased intra-ocular light scattering 11 and floaters, at times with degradation of contrast sensitivity function. 11 – 13 At this point, the condition attains clinical significance and is called “vision degrading myodesopsia.” 14 Apart from age, other factors contributing to fibrous vitreous liquefaction/degeneration include diabetic vitreopathy, 15 inflammation, 16 and myopic vitreopathy, 9 the latter associated with increased incidence of PVD. Persistent vitreo-retinal adhesion can induce anomalous PVD resulting in vitreo-macular traction syndrome, retinal tears, and detachment, 7 at times splitting of the posterior vitreous cortex (vitreoschisis), 17 contributing to premacular membranes with macular pucker and macular hole formation.…”

mentioning

confidence: 99%

“…[11][12][13] At this point, the condition attains clinical significance and is called "vision degrading myodesopsia." 14 Apart from age, other factors contributing to fibrous vitreous liquefaction/degeneration include diabetic vitreopathy, 15 inflammation, 16 and myopic vitreopathy, 9 the latter associated with increased incidence of PVD. Persistent vitreoretinal adhesion can induce anomalous PVD resulting in vitreo-macular traction syndrome, retinal tears, and detachment, 7 at times splitting of the posterior vitreous cortex (vitreoschisis), 17 contributing to premacular membranes with macular pucker and macular hole formation.…”

mentioning

confidence: 99%

“…Persistent vitreoretinal adhesion can induce anomalous PVD resulting in vitreo-macular traction syndrome, retinal tears, and detachment, 7 at times splitting of the posterior vitreous cortex (vitreoschisis), 17 contributing to premacular membranes with macular pucker and macular hole formation. 5,14,18 Anterior vitreous opacification can also occur, particularly after surgical interventions of the posterior lens. [19][20][21] What is not known, however, is whether anterior vitreous changes are associated with central/posterior fibrous liquefaction/degeneration and vision degrading myodesopsia.…”

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confidence: 99%

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