Vitreous amyloidosis as primary manifestation of disease: Case report

Franco, Renata García; Gómez, Alejandro Arias; Roa, Marlon García; Neria, P. Ramírez; Casas, S. Corredor

doi:10.1016/j.oftale.2019.12.009

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2022

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“…The well-described clinical signs of vitreous amyloidosis include glass wool vitreous, perivascular deposits, or opacities attached to the posterior lens capsule, which are referred to as pseudopodia lentis ( 5 ). Diagnosis is based on clinical suspicion, Congo-red staining, and TTR gene sequencing ( 6 ). Vitrectomy may significantly improve visual acuity, but the amyloid deposits may recur because of residual vitreous opacities ( 3 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Vitreous Amyloidosis Caused by a TTR Lys55Asn Mutation With Intraoperative Suprachoroidal Hemorrhage

Wang

Zhang

et al. 2022

Front. Med.

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We report a vitreous amyloidosis patient with white vitreous opacities (footplates) adhering to the posterior lens capsule. A positive Congo-red stain and transthyretin (TTR) Lys55Asn mutation confirmed the diagnosis of vitreous amyloidosis. Optical coherence tomography (OCT) revealed fern-like material adhering to the the posterior pole retinal surface in both eyes. Visual acuity significantly improved after the first vitrectomy, but vitreous opacities recurred 4 years later. The patient appeared to have aggravated sensorimotor neuropathy and severe autonomic dysfunction at the same time. He developed intraoperative suprachoroidal hemorrhage during the second vitrectomy.

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