Vitreon, a new perfluorocarbon.

Blinder, Kevin J.; Peyman, Gholam A.; Paris, Christopher L.; Dailey, James P.; Alturki, Walid A.; Lui, Kwan-Rongl; Gremillion, Charles M.; Clark, Leland C.

doi:10.1136/bjo.75.4.240

Cited by 51 publications

(5 citation statements)

References 15 publications

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“…[ 1 – 3 ] Vitreon (PFCL) has proven to be non-toxic in vitrectomized rabbit eyes for up to 6 weeks. [ 4 ] Ocular toxicity due to retained PFCL, including uncontrolled intraocular pressure,[ 5 ] corneal epithelial toxicity,[ 6 ] and decreased focal sensitivity of the retina[ 7 ] have been reported. In vitro study showed that PFCL is directly toxic to human retinal pigment epithelial cells when exposed to the cells for 7 days.…”

Section: Discussionmentioning

confidence: 99%

Delayed inflammation associated with retained perfluorocarbon liquid

Pradeep

Chhablani

Patel

et al. 2011

Indian J Ophthalmol

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A 55-year-old woman, with history of cataract surgery 1 year back, presented with features of ocular inflammation for last 3 months. She had no history of any other intraocular surgery. On examination, anterior segment showed frothy material in the inferior angle with moderate anterior chamber reaction (cells+/flare+) and sulcus intraocular lens with large posterior capsule rent. Fundoscopy showed multiple, small to medium-sized transparent bubbles of perfluorocarbon liquid (PFCL) with membranes in the vitreous cavity. Ultrasonography confirmed the presence of PFCL in the vitreous cavity. Pars plana vitrectomy with anterior chamber wash was done which led to good visual recovery. To conclude, retained PFCL can cause late onset fibrinous inflammation after a quiescent period but surgical intervention may lead to good visual outcome.

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Section: Discussionmentioning

confidence: 99%

Delayed inflammation associated with retained perfluorocarbon liquid

Pradeep

Chhablani

Patel

et al. 2011

Indian J Ophthalmol

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“…Toxicity also depends on the type of perfluorocarbon. PFO seems to be better tolerated than perfluoroperhydrophenanthrene 14,[24][25][26] but less than perfluorophenathrene 27,28 or perfluoro-octyl-bromide, 29 both of which do not show obvious retinal toxicity after a 6-month tamponade. No differences were observed between perfluoro-N-octane and perfluorodecalin when used as aid in vitreoretinal surgery.…”

Section: Sd-oct Abnormalitiesmentioning

confidence: 91%

Chorioretinal Toxicity of Perfluorooctane (Ala Octa)

Tobalem

Weinberger

Kropp

et al. 2020

American Journal of Ophthalmology

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“…PFCLs are used as soft tools to manipulate, unfold and reappose the retina intraoperatively in cases of complicated retinal detachment, during macular rotation, or for removal of dislocated lenses [5,6,9,15,29,33,34,36,37,39,40,50]. However, at present complete removal of the substance at the end of surgery is recommended because intraocular long-term tolerance is unsatisfactory as demonstrated in animal experiments or described in clinical reports after use in humans [7,12,13,14,16,22,32,35,41,46].…”

Section: Perfluorocarbon Liquidsmentioning

confidence: 99%