Vitreomacular Adhesion in Active and End-Stage Age-related Macular Degeneration

Robison, Craig D.; Krebs, Ilse; Binder, Susanne; Barbazetto, Irene; Kotsolis, Athanasios I.; Yannuzzi, Lawrence A.; Sadun, Alfredo A.; Sebag, J.

doi:10.1016/j.ajo.2009.01.014

Cited by 135 publications

(87 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in cases of adhesion and CNVM, we observed that the hyaloid was always adherent in the membrane area, suggesting that a relationship could indeed exist between CNVM and hyaloid adhesion, as demonstrated in other studies (15,18,19,21,22) . A possible explanation is that a more intense retinal inflammation could be present in some cases of exudative AMD.…”

Section: Discussionmentioning

confidence: 49%

“…Some studies demonstrated higher hyaloid adhesion at all stages of AMD (17,19,20) , whereas others demonstrated higher adhesion rates in the initial phases only (18) . Vitreomacular adhesion was assessed in patients with AMD (17) by dividing patients into exudative AMD, non-exudative AMD, and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that hyaloid adhesion may induce a mild chronic retinal inflammation (18,19) . This is then posited to hinder oxygen penetration and to cause chronic ischemia or VEGF retention in the macular area.…”

Section: Discussionmentioning

confidence: 99%

“…In an alternative assessment of hyaloid adhesion in AMD (18) , two groups were formed; one with druse in one eye and CNVM in the contralateral eye and another with atrophy in one eye and disciform disease in the contralateral eye. The presence of vitreomacular adhesion was evaluated by SD-OCT (OCT-SLO, OCT1000, and Stratus III OCT), and the presence of PVD was evaluated by USG.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, some reports have demonstrated a higher rate of vitreoretinal adhesion in AMD (16)(17)(18)(19)(20)(21)(22) , perhaps contributing to the unfavorable evolution in some cases and/or an insignificant response to intravitreal anti-vascular endothelial growth factor (anti-VEGF).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A study of the vitreoretinal interface in patients with age-related macular degeneration

Martins¹,

Volpatto²,

Emery³

et al. 2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

Approved by the following research ethics committee: Hospital do Servidor Público do Estado de São Paulo. CEEA: 17729713.0.0000.5463. ABSTRACTPurpose: To assess whether hyaloid adhesion is more prevalent in patients with age-related macular degeneration (AMD) than in control patients and to evaluate whether it is more prevalent in exudative AMD than in non-exudative AMD. Methods: This was a cross-sectional, controlled analytical study. Patients from the Ophthalmology Department of the Public Service Hospital of the State of São Paulo were included if they were diagnosed with AMD that was confirmed by fundus biomicroscopy and fluorescein angiography. Patients were divided into three groups: patients without a vitreoretinal disease (controls), patients with exudative AMD, and patients with non-exudative AMD. For the optimal study of the vitreoretinal interface, all patients were subjected to spectral-domain optical coherence tomography (SD-OCT; Cirrus HD-OCT, version 4000; Carl Zeiss Meditec) and ultrasonography (UltraScan®, Alcon). Results with p values of ≤0.05 were considered statistically significant. Results:We assessed 75 eyes of 23 patients with AMD (14 women and nine men) and 15 the control patients (11 women and four men). In total, 33 eyes had AMD that was consistent with the inclusion criteria, of which 11 had the non-exudative form (non-atrophic) and 22 had the exudative form (11 active and 11 disciform scars). Adherence was observed in eight eyes in the control group (26.67%), in seven eyes with exudative AMD (31.82%), and in five eyes with non-exudative AMD (45.45%). Conclusion:Patients with exudative and non-exudative forms of AMD did not present with higher vitreoretinal adhesion than control patients as assessed by SD-OCT and ultrasound. Moreover, patients with exudative AMD (neovascular membrane and disciform scar) did not reveal a higher adherence than those with non-exudative AMD when evaluated by the same methods.

show abstract

Section: Discussionmentioning

confidence: 49%