Vitrectomy for the Diagnosis and Management of Uveitis of Unknown Cause

Margolis, Ron; Brasil, Oswaldo Ferreira Moura; Lowder, Careen Y.; Singh, Rishi P.; Kaiser, Peter K.; Smith, Scott D.; Pérez, Víctor L.; Sonnie, Christine; Sears, Jonathan E.

doi:10.1016/j.ophtha.2007.01.038

Cited by 77 publications

(52 citation statements)

References 13 publications

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“…In other studies, malignant cases represented 0.1-20.4% of all vitreous cytological analyses [6,12,13,16]. The specificity and positive predictive value of cytopathological analyses were also excellent [8,9,14,15,16]. Lymphoma and melanoma were the 2 more frequent malignancies observed in vitreous samples [12,13,16,29].…”

Section: Discussionmentioning

confidence: 89%

“…When compared with lymphomatous vitreous fluids, hyalitis fluids are more cellular. Repeated vitrectomy and appropriate liquid management can improve the diagnosis rate [8,16,20]. For example, vitreous fluid can be collected in a culture medium to avoid cell lysis.…”

Section: Discussionmentioning

confidence: 99%

“…Vitrectomy can also be used as a diagnostic tool in cases of clinically undiagnosed uveitis or uveitis with an atypical clinical course, suspected infectious endophthalmitis or suspicion of intraocular malignancy [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. In these cases, cytological analysis combined with appropriate ancillary testing, such as microbiological analysis, flow cytometry and interleukin (IL) measurement, is a valuable tool that can lead to a final clinical diagnosis in most cases [8].…”

Section: Introductionmentioning

confidence: 99%

“…In these cases, cytological analysis combined with appropriate ancillary testing, such as microbiological analysis, flow cytometry and interleukin (IL) measurement, is a valuable tool that can lead to a final clinical diagnosis in most cases [8]. …”

Section: Introductionmentioning

confidence: 99%

“…Specific vitreous diseases are thus rarely encountered in the routine practice of cytopathologists. Moreover, the vast majority of cytological studies have focused on the distinction between chronic uveitis and primary intraocular lymphoma [4,5,6,8,9,10,11,19]. Only a few studies have described nonneoplastic cytology and routine cytology of vitreous samples [3,12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

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Objective: To describe findings in vitreous fluid samples in routine cytology practice. Study Design: The pathology archives from 1988 to 2008 at our institution were searched for vitreous samples. The slides were reviewed and clinical and follow-up information was obtained. Results: One hundred and eighty-two vitreous fluid samples from 166 patients were analyzed. Most of the samples had been collected for vitreous hemorrhage (75 cases). The second reason for vitreous sample cytological evaluation was an intraocular inflammatory process (55 cases). A specific cause of inflammation was found by combining clinical, microbiological and cytopathological findings in 19 cases, i.e. infection in 7, sarcoidosis in 3, retinal necrosis in 3, lens-induced endophthalmitis in 2, uveitis associated with systemic disease in 2, retrobulbar neuritis in 1 and sympathetic ophthalmia in 1. Among the 19 samples from 16 patients collected to rule out malignancy, 8 had a confirmed intraocular malignancy. Malignant cells were observed in 5 cases (3 lymphomas, 1 melanoma and 1 carcinoma). Undiagnosed malignancies included 2 lymphomas and 1 choroidal melanoma. Other samples were collected during surgery for retinal detachment and cataracts. Conclusions: In routine practice,cytology of the vitreous fluid is performed in many and varied situationsthat are most often nonneoplastic.In nonneoplastic cases, cytology is a useful adjunct to vitrectomy, in spite of its limitations.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

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Fungal Endophthalmitis Developing in Asthmatic Individuals Treated With Inhaled Corticosteroids

Mayercik¹

2011

Arch Ophthalmol

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Estimating the optimal radiotherapy utilization for carcinoma of the central nervous system, thyroid carcinoma, and carcinoma of unknown primary origin from evidence‐based clinical guidelines

Delaney

Jacob

Bartoň

2005

Cancer

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Intraocular lymphoma (IOL) is an extremely rare tumor. We carried out a retrospective cytopathological study with vitreous and intraocular perfusion fluid obtained on conducting a pars plana vitrectomy in 18 cases of IOL. In the 18 cases, nine were patients of Kansai Medical University Takii Hospital from 1991 to 2007, and the other nine had already been reported by other hospitals. Most patients were male, and the average age at onset was 60.4‐year‐old. The main symptoms were vitreous opacity, amblyopia, and blurred vision. Cases of primary intraocular lymphoma numbered 8/15 (53%), while cases of infiltration of malignant lymphoma from the brain numbered 2/15 (13%). Although IOL contains various subtypes of lymphoma, the most frequent subtype is diffuse large B‐cell type lymphoma. It has been reported that making a definite diagnosis of IOL is difficult because the clinical symptoms and examinations are similar to chronic uveitis, and so IOL is called “masquerade syndrome.” Recently, serological and molecular pathological studies have been carried out in addition to morphological examination. However, a cytological diagnosis based on the clinical background and/or image findings is important for the diagnosis of IOL, because of the volume limit of the vitreous fluid and difficulty of obtaining specimens from the inside of the eyes. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.

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Vitrectomy for the Diagnosis and Management of Uveitis of Unknown Cause

Cited by 77 publications

References 13 publications

Cytopathology of Vitreous Humor Samples in Routine Practice

Cytopathology of Vitreous Humor Samples in Routine Practice

Fungal Endophthalmitis Developing in Asthmatic Individuals Treated With Inhaled Corticosteroids

Estimating the optimal radiotherapy utilization for carcinoma of the central nervous system, thyroid carcinoma, and carcinoma of unknown primary origin from evidence‐based clinical guidelines

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