Vitiligo in Mature-Onset Diabetes Mellitus

Dawber, R.P.R.

doi:10.1111/j.1365-2133.1968.tb12298.x

Cited by 75 publications

(28 citation statements)

References 6 publications

(3 reference statements)

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“…There is evidence suggesting that vitiligo is an autoimmune disease: (1) high frequency of the association with other autoimmune diseases, such as thyroid diseases, pernicious anemia and diabetes mellitus [1,4,5,9,15]; (2) high incidence of various autoantibodies in sera [2][3][4]; (3) the presence of antimelanin antibodies in the sera [14].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Vitiligo with Oral Corticosteroids

Imamura¹,

Tagami²

1976

Dermatology

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17 patients with generalized vitiligo and 5 patients with localized vitiligo were treated with oral corticosteroids. Six patients with generalized vitiligo showed over 75% repigmentation in at least one of the patches. Two patients with generalized vitiligo and 1 patient with localized vitiligo showed a partial repigmentation of 25-75%, while 5 patients with generalized vitiligo and 1 patient with localized vitiligo showed a minimal repigmentation of less than 25%. Four patients with generalized vitiligo and 3 patients with localized vitiligo failed to respond. Repigmentation became evident within 4 weeks in most cases, and in general was more markedly noted in exposed areas.

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Section: Discussionmentioning

confidence: 99%

Treatment of Vitiligo with Oral Corticosteroids

Imamura¹,

Tagami²

1976

Dermatology

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“…6,7 In our study we have evaluated for associated systemic illness which showed 8% of patient had diabetes mellitus, where similar results is seen in a study by Dauber et al One patient had hypothyroidism and one had hyperthyroidism when compared to 7 % cases were associated with graves diseases in a study. 8 Altar et al in a study on 192 vitiligo patients in the age group 6-60 years found that generalised type of vitiligo was present in 72.9%. Among patients with vitiligo, 84% were thyroid, 15% hypothyroid and 1% hyperthyroid which is comparable to our study.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of vitiligo cases in Government Dharmapuri Medical College Hospital

Akila¹

2018

Int J Res Dermatol

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Background: Vitiligo is a pigmentary disorder of skin whose precise etiology is not known, though it is considered to be genetic, an autoimmune skin disorder in which there is a loss of skin pigment. This disease can occur at any age. Vitiligo affects various parts of the body. Though various modalities of treatment became available, still produces significant social stigma and leads to a psychological impact on the patient.Methods: 100 cases of vitiligo patients attending Dermatology outpatient Department at Govt Dharmapuri Medical college hospital during the period of January 2017 to June 2017 were included in the study. Informed consent was obtained from all the patients and from parents in case of children. A detailed history was obtained and dermatological/systemic examination was done using a proforma. Necessary investigations were done. A psychiatric evaluation was done for all.Results: Females were more involved than males in our study. The youngest patient recorded in our study is 6 years. Exposed areas are more involved. The leg is the most common site involved followed by hands. 8 percent of patients had associated diabetes mellitus, hypothyroidism (2%), and hyperthyroidism (1%). Depression was seen in 8 percent of the patients. Marital conflict (3%) and delayed marriage (5%) was recorded in the study.Conclusions: Though various research studies and treatment modalities became available for this pigmentary disorder it still remains a social stigma. Females were little more involved in our study which may be due to a cosmetic concern. Associated diabetes mellitus and thyroid disorders support autoimmune etiology.

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“…Dawber et al found that 4.8% of diabetics had vitiligo 4.5% to 7.7% frequency of vitiligo has been reported in late onset of diabetes. 15 Hajini GH et al though associated with both insulin dependent and non insulin dependent types of diabetes, in most of patients it is seen after age of 40 years. 16 In present study 2% of total patients having vitiligo were observed and both of them were of above 40 years.…”

Section: Vitiligomentioning

confidence: 99%

A study of cutaneous manifestations associated with diabetes mellitus

Kadam¹,

Soni²,

Phatale

et al. 2016

Int J Adv Med

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Background: Diabetes mellitus is a fairly common medical disorder that involves almost every specialty in its spectrum of clinical manifestation, and up to 1/3 rd of patients with diabetes mellitus are estimated to have cutaneous changes. In other words using broadest criteria all subjects with diabetes will diabetes will develop cutaneous manifestations of this disease. Methods: A total of 100 diabetic patients with cutaneous manifestations, who attended skin OPD at Civil Hospital, Belgaum, Karnataka, India and K.L.E'S Hospital and Medical Research Centre, were randomly selected. The present study was conducted over a period of 22 months from March 1995 to December 1996. Total 100 cases were included in this study. The male to female ratio is 1.6:1 approximately. Detailed history, physical examination, cutaneous and mucous membrane involvement examination was done. Diabetes Mellitus was confirmed by urine sugar and blood sugar estimation. The diagnosis of diabetes mellitus was done on the basis of criteria laid down by national diabetic data group. Urine and blood sugar estimation was done in all the cases. Results: Fungal infections were common cutaneous manifestation followed by bacterial infections and generalized pruritus. Those patients who were on oral hypoglycaemic drugs, insulin therapy found to have photodermatitis and localized lipoatrophy. The common associated skin diseases with diabetes mellitus were fungal infection (38%) and viral infections (2%). Unexplained generalized pruritus was observed in (17%) cases, followed by pruritus ani is (3%) and prurigo simplex in (1%). Cutaneous markers of diabetes i.e acrochordons were observed in 17% cases. The other manifestations observed were lichen planus (6%), PLE (3%), psoriasis (3%), vitiligo (2%), Kyrles disease (2%), infected eczema (2%), scabies (2%), lichen simplex chronicus (2%) and pemphigus vulgaris (1%). Conclusions:The physicians should be aware of cutaneous manifestations in diabetes mellitus. Where the ignorance of skin manifestations in diabetes or improper treatment may makes the condition worse. The early detection and early treatment of common skin manifestations in diabetes will prevent further complications or ineffectiveness due to treatment especially in cases of carbuncle, extensive tinea corporis, psoriasis, lichen planus, macro and micro angiopathies, trohic ulcers etc. A well-controlled diabetes by drugs, diet and exercise will allow the patient to lead a normal life like any other normal individuals.

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Vitiligo in Mature-Onset Diabetes Mellitus

Cited by 75 publications

References 6 publications

Treatment of Vitiligo with Oral Corticosteroids

Treatment of Vitiligo with Oral Corticosteroids

A prospective study of vitiligo cases in Government Dharmapuri Medical College Hospital

A study of cutaneous manifestations associated with diabetes mellitus

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