Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence

Abstract

Vitiligo is a depigmentation disorder characterized by the loss of melanocytes in the skin, which is aggravated by oxidative stress. The relationship between oxidative stress and cellular senescence is still unclear despite considerable research on melanocyte senescence in vitiligo in recent years. Many chronic diseases associated with oxidative stress, that is, degenerative diseases, have been shown to ultimately result in cellular senescence due to sustained activation of reactive oxygen species. This study advances research on the pathophysiology of vitiligo and its treatment options by summarizing the role of oxidative stress and melanocyte senescence in vitiligo and investigating the mechanisms behind the interaction of melanocyte senescence with oxidative stress. Keywords: Vitiligo, melanocytes, oxidative stress, cellular senescence, age

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