Vitiligo and Mental Health: Natural Compounds’ Usefulness

Bartolomeo, Luca Di; Custurone, Paolo; Irrera, Natasha; Borgia, Francesco; Vaccaro, Federico; Squadrito, Francesco; Vaccaro, Mario

doi:10.3390/antiox12010176

Cited by 4 publications

(6 citation statements)

References 85 publications

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“…Instead, recent studies shed new light on the possibility of contributing to the stress, psychological and genetic factors in such diseases [25,34,35]. Indeed, stressful events and psychological disorders have shown to have a role in the onset and aggravation of vitiligo [35,36]. This was evident during this study when the vitiligo patients were asked if they were been exposed to psychological disorders or suffered from any hereditary problems during their livelihood.…”

Section: Discussionmentioning

confidence: 94%

“…Actually, many dermatological diseases were shown to be linked to blood types and hence it was envisaged that producing antimelanocyte antibodies in vitiligo would be likely triggered by blood type alloantigens [20,33]. Instead, recent studies shed new light on the possibility of contributing to the stress, psychological and genetic factors in such diseases [25,34,35]. Indeed, stressful events and psychological disorders have shown to have a role in the onset and aggravation of vitiligo [35,36].…”

Section: Discussionmentioning

confidence: 99%

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Association of Vitiligo with ABO/Rh System and its Influence on Thyroid Stimulating Hormone and Vitamin D

Ashawesh

2024

Alq J Med App Sci

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This study was conducted to determine if there is a relationship between vitiligo and ABO blood groups, the Rhesus (Rh) factor, thyroid stimulating hormone (TSH) and vitamin D. For vitiligo analysis, two hundred subjects participated in this study, 100 vitiligo patients and 100 control cases (without vitiligo). ABO blood grouping and Rh typing were tested by a slide method. TSH testing involved 80 vitiligo patients and 80 controls (without vitiligo) and the hormone was analyzed by separating the serum in a centrifuge for two minutes and the results were obtained by Beckman fully automatic analyzer. For vitamin D, 50 vitiligo patients and 50 healthy people (without vitiligo) were included. The data on vitamin D were obtained from private laboratory services. Statistical analysis was performed using IBM SPSS version 26. P<0.05 was considered significant. Most patients with vitiligo had a significantly lower level of serum vitamin D compared with controls (p-value < 0.05), while no statistically significant difference in TSH serum levels between vitiligo cases and controls, was found (p-value > 0.05). Furthermore, despite showing that subjects with blood group O are more susceptible to vitiligo as compared to other groups, there was no significant association of vitiligo with ABO blood groups (p-value > 0.05). Similarly, the incidence of Rh positive and Rh negative was not statistically different between the two groups (p-value > 0.05). This study showed that vitiligo patients are often vitamin D deficient. This study highlights the need to evaluate vitamin D status in vitiligo patients to improve the level of skin pigment loss. It remains unknown whether vitamin D deficiency causes vitiligo. However, a collection of larger sample sizes of different ethnicities should be required to achieve a precise conclusion.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Association of Vitiligo with ABO/Rh System and its Influence on Thyroid Stimulating Hormone and Vitamin D

Ashawesh

2024

Alq J Med App Sci

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“…Our findings appear to diverge from the majority of prior observational investigations. Numerous previous studies on the mental health status of vitiligo patients have consistently demonstrated that, in comparison to the general population, vitiligo patients are more likely to experience mental disorders, such as schizophrenia, depression and anxiety, as well as higher rates of hospitalization and costs for inpatient care for all varieties of psychological disorders 5,7,8,31 . Besides, in case–control research conducted by Liu et al., it was shown that 204 (49.5%) of the 409 patients experienced insomnia 32 .…”

Section: Discussionmentioning

confidence: 98%

“…Numerous previous studies on the mental health status of vitiligo patients have consistently demonstrated that, in comparison to the general population, vitiligo patients are more likely to experience mental disorders, such as schizophrenia, depression and anxiety, as well as higher rates of hospitalization and costs for inpatient care for all varieties of psychological disorders. 5,7,8,31 Besides, in case-control research conducted by Liu et al, it was shown that 204 (49.5%) of the 409 patients experienced insomnia. 32 Nevertheless, utilizing genetic variants as instrumental variables, MR analysis enables the elucidation of the true causality between vitiligo and mental disorders while mitigating the influence of confounding factors.…”

Section: Ta B L Ementioning

confidence: 98%

Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization

Wang,

Yao,

Lin

et al. 2023

Experimental Dermatology

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Although a large number of existing studies have confirmed that people with vitiligo are prone to mental disorders, these observational studies may be subject to confounding factors and reverse causality, so the true causal relationship is inconclusive. We conducted a bidirectional Mendelian randomization (MR) analysis to assess the causality between vitiligo and mental disorders, namely depression, anxiety, insomnia, schizophrenia, bipolar disorder, obsessive‐compulsive disorder (OCD) and attention‐deficit hyperactivity disorder (ADHD). Summary statistics from large available genome‐wide association study (GWAS) datasets for generalized vitiligo (n = 44 266), depression (n = 173 005), anxiety (n = 17 310), insomnia (n = 386 988), schizophrenia (n = 130 644), bipolar disorder (n = 413 466), OCD (n = 9725) and ADHD (n = 225 534) were utilized. Inverse‐variance weighted (IVW), MR‐Egger and weighted median were employed to estimate causal effects. Sensitivity analysis and MR Pleiotropy Residual Sum and Outliers (MR PRESSO) were conducted to assess heterogeneity and pleiotropy, ensuring the robustness of the results. Additionally, we corrected for estimating bias that might be brought on by sample overlap using MRlap. In our findings, none of the rigorous bidirectional MR analyses uncovered a significant causal association. Even after applying the MRlap correction, the effect sizes remained statistically nonsignificant, thereby reinforcing the conclusions drawn via IVW. In summary, our genetic‐level investigation did not reveal a causal link between generalized vitiligo and mental disorders.

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“…The term “nutraceutical”, formed by combining the words “nutrition” and “pharmaceuticals”, is known as any natural compound derived from food or part of it that provides a medical advantage [ 12 ]. Studies have shown that some of these natural extracts may exert anti-inflammatory, antioxidant, and antiproliferative effects [ 13 ], demonstrating their possible use for the treatment of different cutaneous diseases [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

Peterle

Sanfilippo

Borgia

et al. 2023

Foods

Self Cite

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Skin cancer is a prevalent type of cancer worldwide and has a high growth rate compared to other diseases. Although modern targeted therapies have improved the management of cutaneous neoplasms, there is an urgent requirement for a safer, more affordable, and effective chemoprevention and treatment strategy for skin cancer. Nutraceuticals, which are natural substances derived from food, have emerged as a potential alternative or adjunctive treatment option. In this review, we explore the current evidence on the use of omega-3 fatty acids and polyphenols (curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein) for the treatment of melanoma and non-melanoma skin cancer (NMSC), as well as in their prevention. We discuss the mechanisms of action of the aforementioned nutraceuticals and their probable therapeutic benefits in skin cancer. Omega-3 fatty acids, curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein have several properties, among which are anti-inflammatory and anti-tumor, which can help to prevent and treat skin cancer. However, their effectiveness is limited due to poor bioavailability. Nanoparticles and other delivery systems can improve their absorption and targeting. More research is needed to evaluate their safety and effectiveness as a natural approach to skin cancer prevention and treatment. These compounds should not replace conventional cancer treatments, but may be used as complementary therapy under the guidance of a healthcare professional.

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Vitiligo and Mental Health: Natural Compounds’ Usefulness

Cited by 4 publications

References 85 publications

Association of Vitiligo with ABO/Rh System and its Influence on Thyroid Stimulating Hormone and Vitamin D

Association of Vitiligo with ABO/Rh System and its Influence on Thyroid Stimulating Hormone and Vitamin D

Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

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