Vitiligo and major depressive disorder: A bidirectional population-based cohort study

Vallerand, Isabelle A.; Lewinson, Ryan T.; Parsons, Laurie; Hardin, Jori; Haber, Richard M.; Lowerison, Mark; Barnabé, Cheryl; Patten, Scott B.

doi:10.1016/j.jaad.2018.11.047

Cited by 35 publications

(25 citation statements)

References 24 publications

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“…A case–control study from Scandinavia determined there was an increased incidence of RA for those determined to have had a stressful life event within the past year compared to osteoarthritis controls, although the retrospective nature of this study is a methodological limitation [22]. It has been demonstrated recently that mental disorders such as depression can increase the risk of another inflammatory arthropathy, psoriatic arthritis [23], as well as other autoimmune diseases including inflammatory bowel disease [24], alopecia areata [25], and vitiligo [26] among others [27], thus further supporting the temporal nature of these inflammatory relationships.…”

Section: Epidemiologic Evidence Of Depression As a Risk Factor For Rhmentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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Purpose of review Rheumatoid arthritis (RA) is associated with negative changes in mental health. This is generally attributed to symptoms of inflammation and the adverse impact of RA on quality of life and functioning. Until recently, causal pathways in the opposite direction have not been fully appreciated. This review examines the recent literature on the risk of RA associated with depression. Recent findings Current literature links depression with an increased risk of RA and with a more detrimental disease course. These effects are likely to be partially mediated by negative effects of depression on coping with RA and on factors such as medication adherence, both of which lead to poorer disease outcomes. Growing evidence also suggests that inflammation is central both to depression and RA and may account for some of the complex interplay between these conditions. Summary Awareness of a bidirectional relationship between depression and RA through a biopsychosocial framework may assist clinicians in maintaining an appropriate index of suspicion about the co-occurrence of these conditions. This review also suggests an important need for integration of rheumatologic and mental health services and generates hypotheses for future research towards a better understanding of both depression and RA.

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Section: Epidemiologic Evidence Of Depression As a Risk Factor For Rhmentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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“…12 Another cohort study following incident vitiligo (7104 individuals) and referent (6 137 696 individuals) cohorts until the development of MDD demonstrated that patients with vitiligo diagnoses had a 27% increased risk for MDD than those without vitiligo (crude HR, 1.27 [95% CI, 1.16-1.40]; P < 0.001). 13 Our study introduced the incidence rate of these psychological comorbidities with adjusted HR of 3.845 (P < 0.001) for anxiety and 3.721 (P < 0.001) for depression. Besides, we emphasized the increased risk of OCD, manic disorder, bipolar disorder and schizophrenia in patients with vitiligo which are rarely discussed.…”

Section: Discussionmentioning

confidence: 99%

“…A meta‐analysis of 29 studies with 2530 people with vitiligo comprehensively observed that pooled prevalence for clinically diagnosed depression and anxiety was 0.21 (95% CI, 0.15–0.28) and 0.15 (95% CI 0.06–0.24), respectively . Another cohort study following incident vitiligo (7104 individuals) and referent (6 137 696 individuals) cohorts until the development of MDD demonstrated that patients with vitiligo diagnoses had a 27% increased risk for MDD than those without vitiligo (crude HR, 1.27 [95% CI, 1.16–1.40]; P < 0.001) . Our study introduced the incidence rate of these psychological comorbidities with adjusted HR of 3.845 ( P < 0.001) for anxiety and 3.721 ( P < 0.001) for depression.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of psychiatric disorders in adult patients with vitiligo: A nationwide, population‐based cohort study in Taiwan

Chen

Wang

Chung

et al. 2020

The Journal of Dermatology

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Vitiligo is an autoimmune skin disease that has a major impact on the quality of life of patients. However, a nationwide study of the association between vitiligo and the incidence of inclusive psychiatric diseases has not been conducted in the Asian population. Therefore, this study aimed to analyze the association between vitiligo and the risk of psychiatric disorders using a nationwide database in Taiwan. Data were collected from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 1432 subjects with vitiligo and 5728 age-, sex-and index year-matched controls were enrolled in this study. Patients with vitiligo tend to have more coexisting psychiatric disorders than healthy individuals, regardless of their sex, age group and facility level of care. After adjusting for sex, age, comorbidity, urbanization and facility level of care, the adjusted hazard ratio of overall psychiatric disorders for patients with vitiligo was 2.926 (95% confidence interval [CI], 2.646-3.236; P < 0.001). Among them, the highest adjusted hazard ratios were found for obsessive-compulsive disorder, at 10.790 (95% CI,; P < 0.001). Vitiligo is associated with an increased risk of various psychiatric disorders. By providing a better understanding of the psychosocial burden associated with vitiligo, these results emphasize the need to evaluate the mental health of patients with vitiligo by treating physicians.

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“…Diseases such as alopecia areata and vitiligo have been found to have a bidirectional relationship with depression in large scale cohort studies. [ 25 26 ] A systematic review of 35 studies found that chronic pruritus that is unresponsive to topical treatment and oral antihistamines will benefit from oral antidepressants (fluoxetine, fluvoxamine, paroxetine, sertraline, amitriptyline, nortriptyline, doxepin, and mirtazapine). [ 27 ] Indications for antidepressants are outlined in Table 7 .…”

Section: Antipsychoticsmentioning

confidence: 99%