Vitiligo and Autoimmunity

Kasumagić-Halilovic, Emina; Ovčina-Kurtović, Nermina; Jukic, Tomica; Karamehić, Jasenko; Begovic, Begler; Samardzic, Sladjana

doi:10.5455/medarh.2013.67.91-93

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…Study of Kasumagic-Halilovic et al found high levels of anti-TPO in 11 (27%) out of 40 vitiligo patients and they demonstrated significantly elevated levels of anti-TPO compared to the control group [ 8 ]. Elevated anti-TPO antibody was present in 14.8% of our patients.…”

Section: Discussionmentioning

confidence: 99%

The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

Kurtipek

Ci̇han

Demirbaş

et al. 2015

BioMed Research International

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Aim. Many studies demonstrated that alopecia areata (AA) and vitiligo are commonly associated with autoimmune thyroid diseases. We aimed to investigate the frequency of thyroid dysfunctions and autoimmunity related with vitiligo and AA. Material and Methods. 200 patients, 92 AA and 108 vitiligo diagnosed, were surveyed retrospectively. The control population was in reference range and from Konya, central Anatolian region of Turkey. Thyroid function tests (free T3, free T4, and TSH) and serum thyroid autoantibody (anti-TG, anti-TPO) levels were evaluated in all patients. Results. In vitiligo patients, 9 (8.3%) had elevated anti-TG levels and 16 (14.8%) had elevated anti-TPO, and in 17 patients (15.7%) TSH levels were elevated and 3 (2.8%) patients had elevated fT4 levels and 5 (4.6%) had elevated fT3 levels. Within AA patients, 2 (2.2%) had anti-TG elevation and 13 (14.1%) had anti-TPO elevation, in 7 patients (7.6%) TSH were elevated, and in 1 patient (1.1%) fT4 were elevated and 5 (5.4%) patients had elevated fT3 levels. Conclusion. In our study, impaired thyroid functions and thyroid autoantibodies in vitiligo and AA patients were identified at lower rates than the previous studies. According to results of this study there is no need for detailed examination in alopecia areata and vitiligo patients without clinical history.

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Section: Discussionmentioning

confidence: 99%

The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

Kurtipek

Ci̇han

Demirbaş

et al. 2015

BioMed Research International

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“…Over the years, multiple aspects of biochemical, immunological and other biological aspects that play a role in the pathogenesis of vitiligo have been studied [1][2][3][4][5][6][7]. For the last decade or so, the potential role of ROS in vitiligo patients was extensively studied by Schallreuter and colleagues [13][14][15][16][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

“…It is now considered to be one of the most common pigmentary disorders, which involves complex interaction of environmental and immunological factors that ultimately lead to melanocytes destruction, resulting in the characteristic depigmented lesion [2,3]. The complete aetiology of vitiligo remains obscure despite being in focused debate for the last six decades [4,5], and hence, it is important to unravel the underlying pathomechanisms of vitiligo. Although the exact pathogenesis of vitiligo is unknown, but the occurrence of autoimmune reactions have been assumed [4,6], the presence of autoantibodies and various underlying immunologic abnormalities in the affected sites of these patients have also been reported [6,7], but the precise mechanism of generation of autoantibodies in vitiligo remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…The complete aetiology of vitiligo remains obscure despite being in focused debate for the last six decades [4,5], and hence, it is important to unravel the underlying pathomechanisms of vitiligo. Although the exact pathogenesis of vitiligo is unknown, but the occurrence of autoimmune reactions have been assumed [4,6], the presence of autoantibodies and various underlying immunologic abnormalities in the affected sites of these patients have also been reported [6,7], but the precise mechanism of generation of autoantibodies in vitiligo remains unclear. Vitiligo patients have specific losses of integumentary melanocytes, so there is a possibility that one or more key enzymes involved in melanogenesis could be important autoantigens in the disease pathogenesis [8].…”

Section: Introductionmentioning

confidence: 99%

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Oxidized tyrosinase: A possible antigenic stimulus for non-segmental vitiligo autoantibodies

Al‐Shobaili

Rasheed

2015

Journal of Dermatological Science

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“…2). Among the different theories developed, namely, autoimmunity, oxidative stress, melanocyte growth and defective melanocyte adhesion, viral infections, and neural mechanisms, the autoimmune theory is currently considered and accepted as the leading theory globally, which has been substantiated by several reports on the frequent association of vitiligo with autoimmune diseases (Rezaei et al 2007;Le Poole and Luiten, 2008;Kasumagic-Halilovic et al 2013;Strassner and Harris 2016). Also, the association of vitiligo with halo naevus, which is characterized by depigmented halo-like area circumscribing a mole encompassing dense immune cell infiltrate, further supports the importance of immune mechanisms in vitiligo development (Spritz 2010).…”

Section: Classification Of Vitiligomentioning

confidence: 99%

Exploring vitiligo susceptibility and management: a brief review

Rahman

Hasija

2018

biomed dermatol

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Background: Vitiligo is a common dermatological disorder of chronic depigmentation which is phenotypically characterized by white macules on the skin caused as a result of the systematic destruction of functional melanocytes. This review provides an overview of vitiligo, its etiopathogenesis and disease management, and also discusses the scope of network-interaction studies and polypharmacological studies in understanding vitiligo disease module. Methods: A narrative review of the relevant published literatures known to the authors that comprehensively discussed about vitiligo and its implications was conducted. Results: Emerging evidence underlines the existing connection between deregulated miRNA function and vitiligo pathogenesis. It has also been linked with autoimmunity for the cause of melanocyte death in susceptible individuals. Alteration of genetic factors involved in immune responses and melanogenesis along with environmental factors are central to disease manifestation. Screening methods as such are not available for vitiligo, and the diagnosis is based on the assessment of the absence of melanocytes from the lesions in the affected area. With the occurrence of vitiligo at any age, most people typically develop it at a young age. Depending on the disease course and duration, clinical management primarily involves disease stabilization either by repigmentation or depigmentation of the skin. Conclusions: Several questions remain unsolved which indeed makes vitiligo an excellent model for studying autoimmune and degenerative processes. An understanding of the underlying degenerative mechanisms and unraveling the biological mediators of melanocyte loss will open up avenues for testing novel therapeutic approaches in vitiligo management. Such studies can revolutionize our apprehension of the molecular interconnections that underpin vitiligo pathogenesis.

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Vitiligo and Autoimmunity

Cited by 15 publications

References 16 publications

The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

Oxidized tyrosinase: A possible antigenic stimulus for non-segmental vitiligo autoantibodies

Exploring vitiligo susceptibility and management: a brief review

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