Vitiligo: A White Patch that Affects the Soul

Roy, Aravind

doi:10.4172/2376-0427.1000254

Cited by 2 publications

(2 citation statements)

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“…Vitiligo is one of the most common acquired skin pigmentation disorders, affecting 0.5–2% of the population worldwide regardless of age, gender, color or ethnic origin (Ongenae et al, 2004, Roy, 2017). The disease is characterized by the development of milky white patches, usually with a typical symmetrical distribution pattern (Ongenae et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of neat and binary vehicle systems on the solubility and cutaneous delivery of piperine

Alomrani

Alhazza

AlGhamdi

et al. 2018

Saudi Pharmaceutical Journal

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Vitiligo is a skin disease characterized by depigmentation disorders due to lack of melanin production. Piperine, an alkaloid extracted from black piper, is active in melanocytes proliferation. To achieve this, the drug has to reach the melanocytes which exist in the deep layer of the epidermis. Higher drug concentration can be obtained after application of optimized formulation to skin. Accordingly, the aim of this work is to investigate the effect of vehicles on skin penetration of piperine as the first step in development of optimized formulation. The tested vehicles include ethanol (Eth), propylene glycol (PG), polyethylene glycol 400 (PEG), and oleic acid (OA) and their combinations. Water was used as the control and skin permeation was monitored using rabbit ear model skin. The highest piperine solubility (48.6 mg/ml) and flux (40.8 μg/cm h) was achieved by Eth and the lowest piperine flux (1.17 μg/cm h) was reported for PEG. PG and OA showed piperine flux values comparable to that of the control. Among different combination systems, Eth-OA (75:25) binary system had the highest piperine flux (59.3 μg/cm h) followed by Eth-OA (50:50) (32.3 μg/cm h) and PG-OA (90:10) (22.7 μg/cm h). The study thus introduced a vehicle system as the first step in the development of topical formulation of piperine.

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Section: Introductionmentioning

confidence: 99%

Effect of neat and binary vehicle systems on the solubility and cutaneous delivery of piperine

Alomrani

Alhazza

AlGhamdi

et al. 2018

Saudi Pharmaceutical Journal

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“…Long term maintenance sessions with IPL are suggested for melasma patients. In another short commentary, the safety issue of microbiological contamination, the allergic reaction, and toxicity of the ink product, and the regulation of tattoo ink was also discussed [6][7][8][9][10].…”

Section: Editors' Messagementioning

confidence: 99%

Pigmentary Disorders: The Bizarre Truth of Pigmentary Disorders

Chen¹

2017

J Pigment Disord

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In this coming issue of March 2017, the Journal of Pigmentary Disorders brings us some interesting skin color related articles and a wide variety of pigment related researches.Firstly, the spectrum of vitiligo is reviewed. The treatment of vitiligo with co-culture of melanocytes derived from hair follicle with adiposederived stem cells was also studied. In this study, stem cell concentration appeared to be one of the major factors affecting the degree of repigmentation. The use of NB-UVB after intraepidermal injection of melanocyte also showed highly statistically significance in repigmentation [1][2][3][4][5].As for treatment of pigmented lesion in Greece, it was found that the Alexandrite laser has excellent results for freckles, while the combination of chemical peelings and fractional laser is good for the treatment of melasma. On the other hand, a literature review was made to understand the current practice of treatment for pigmented lesions in Taiwan. The authors found the traditional Q-switched Nd-YAG laser, Q-switched alexandrite laser, or IPL work with similar results for epidermal pigmented lesions like freckles and lentigines. Long term maintenance sessions with IPL are suggested for melasma patients. In another short commentary, the safety issue of microbiological contamination, the allergic reaction, and toxicity of the ink product, and the regulation of tattoo ink was also discussed [6-10].Coronoid lamellation is pathognomonic of porokeratosis, but it can also be found in a wide range of inflammatory, hyperplastic and neoplastic skin conditions. Its appearance in two unique cases of giant verrucous psoriasis and inflammatory linear verrucous epidermal nevus (ILVEN) were reported. Other rare cases like erythrokeratoderma variabilis, trisomy 8 mosaicism syndrome, Bier spots and adiposis dolorosa were described [11].Hair related disorder can play a significant role in people's physical appearance. Premature canities and many related genetic disorders were reviewed. Frontal fibrosing alopecia is another common hair disorder which may be confused with lichen planopilaris. A detailed review can be found in this issue. In rare cases, eyelash demodicosis should be considered in chronic non-diagnosed blepharitis and palpebra skin lesions. An outbreak of demodex eyelash infection in Greece with the treatment of tea tree oil was reported [12].Finally, phototherapy with pulsed light and heat energy (LHE) was used to treat mild forms of acne. It was found that phototherapy has an obvious advantage in the treatment of mild grade of acne vulgaris when compared with topical adapalene treatment [13][14][15].These articles in the issue of March 2017 provide us more understandings and knowledge of the pigment related skin disorders. We hope that all the above articles will bring a positive impact to the dermatological scientific community. References

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Vitiligo: A White Patch that Affects the Soul

Abstract: Vitiligo may be a future skin condition characterized by patches of the skin losing their pigment.

Cited by 2 publications

References 57 publications

Effect of neat and binary vehicle systems on the solubility and cutaneous delivery of piperine

Effect of neat and binary vehicle systems on the solubility and cutaneous delivery of piperine

Pigmentary Disorders: The Bizarre Truth of Pigmentary Disorders

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