Vitexin, Isovitexin and Other Biochemical Constituent of Ficus Deltoidea Leaf Extract in 80% Methanol Inhibits Cholinesterase Enzymes on Javanese Medaka (Oryzias Javanicus) Model

Hassan, Ibrahim M.; Ibrahim, Wan Nazihah Wan; Yusuf, Ferdaus Binti Mohamat; Ahmad, Siti Aqlima; Ahmad, Siti Hajar

doi:10.52547/rabms.7.4.179

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…These results suggest that salicylic acid and wedelolactone play significant roles in the anti-AChE activity of the EPL extract. In addition, the high AChE inhibition potential may be due to the high levels of epicatechin gallate, myricetin, isovitexin, apigetrin [54,55] components in the EPL extract. These components also exhibit a high ability to inhibit AChE, as indicated by their IC 50 values presented in Table 6.…”

Section: Assessment Of Novel and Potential Medical Effects Of Eclipta...mentioning

confidence: 99%

Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam

Phan,

Wang,

Nguyen

et al. 2023

Pharmaceuticals

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Eclipta prostrata L. (EPL), a medicinal plant, is widely utilized in the central highlands of Vietnam. This study aims to assess the chemical profile and potential medical effects of an EPL extract rich in flavonoids. A total of 36 secondary metabolites were identified from the EPL extract through GC-MS and UHPLC-UV analysis. Among them, 15 volatile compounds and several phenolic and flavonoid chemicals, including salicylic acid, epicatechin gallate, isovitexin, and apigetrin, were reported in EPL extract for the first time. This herbal extract demonstrated moderate inhibition against α-amylase and α-glucosidase, and high anti-oxidant and anti-acetylcholinesterase activities (IC50 = 76.8 ± 0.8 μg/mL). These promising attributes can be likely attributed to the high levels of major compounds, including wedelolactone (1), chlorogenic acid (3), epicatechin gallate (6), salicylic acid (8), isovitexin (9), apigetrin (11), and myricetin (12). These findings align with the traditional use of EPL for enhancing memory and cognitive function, as well as its potential benefits in diabetes management. The results of the molecular docking study reveal that the major identified compounds (1, 6, 9, and 11) showed a more effective acetylcholinesterase inhibitory effect than berberine chloride, with good binding energy (DS values, −12.3 to −14.3 kcal/mol) and acceptable values of RMSD (1.02–1.67 Å). Additionally, almost all the identified major compounds exhibited good ADMET properties within the required limits.

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Section: Assessment Of Novel and Potential Medical Effects Of Eclipta...mentioning

confidence: 99%

Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam

Phan,

Wang,

Nguyen

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Vitexin, Isovitexin and Other Biochemical Constituent of Ficus Deltoidea Leaf Extract in 80% Methanol Inhibits Cholinesterase Enzymes on Javanese Medaka (Oryzias Javanicus) Model

Cited by 1 publication

References 47 publications

Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam

Assessment of the Chemical Profile and Potential Medical Effects of a Flavonoid-Rich Extract of Eclipta prostrata L. Collected in the Central Highlands of Vietnam

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