Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice

Qin, Zhiqiang; Xiang, Lan; Zheng, Sujun; Zhao, Yuchen; Yun, Qin; Zhang, Lei; Zhou, Lanlan

doi:10.1016/j.biopha.2023.115101

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Recent studies suggest that chemicals from traditional Chinese medicines such as vitexin (apigenin-8-C-glucoside) [87] or cimifugin (from the herb Saposhnikovia divaricata) [88] may target TRPV4 to relieve acute and chronic itch. Thus, TRPV4 appears to be a good target for the development of drugs to alleviate itch.…”

Section: Trp Cation Channel Subfamily V (Vanilloid) Member 4 (Trpv4)mentioning

confidence: 99%

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

Tsagareli,

Follansbee,

Iodi Carstens

et al. 2023

Pharmaceuticals

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Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch-evoking ligands. Also expressed in pruriceptors are several types of Transient Receptor Potential (TRP) channels. TRP channels are a diverse class of cation channels that are responsive to various somatosensory stimuli like touch, pain, itch, and temperature. In pruriceptors, TRP channels can be activated through intracellular signaling cascades initiated by pruritogen receptors and underly neuronal activation. In this review, we discuss the role of TRP channels TRPA1, TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPC3/4 in acute and chronic pruritus. Since these channels often mediate itch in association with pruritogen receptors, we also discuss Mas-related G-protein-coupled receptors (Mrgprs) and protease-activated receptors (PARs). Additionally, we cover the exciting therapeutic targets amongst the TRP family, as well as Mrgprs and PARs for the treatment of pruritus.

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Section: Trp Cation Channel Subfamily V (Vanilloid) Member 4 (Trpv4)mentioning

confidence: 99%

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

Tsagareli,

Follansbee,

Iodi Carstens

et al. 2023

Pharmaceuticals

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Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway

Chai,

He,

Liang

et al. 2024

Heliyon

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Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment

Go,

Lee,

Kim

et al. 2024

Biomolecules

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Chronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of the site-specific expression of TRP channels and their associated functions in response to a range of pruritogens. Although several potent antipruritic compounds that target specific TRP channels have been developed and have demonstrated efficacy in various chronic itch conditions through experimental means, a more thorough understanding of the potential for adverse effects or interactions with other TRP channels or GPCRs is necessary to develop novel and selective therapeutics that target TRP channels for treating chronic itch. This review focuses on the mechanism of itch associated with TRP channels at specific sites, from the skin to the sensory neuron, with the aim of suggesting specific therapeutic targets for treating this condition.

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Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice

Cited by 3 publications

References 34 publications

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway

Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment

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