Vitellogenin is an acute phase protein with bacterial-binding and inhibiting activities

Background: Vitellogenin is a central regulator of honey bee life span by largely unknown mechanisms. Results: Honey bee vitellogenin has membrane affinity that is connected to cell damage recognition and antioxidant function. Conclusion: Membrane binding documents a new molecular behavior among vitellogenins. Significance: Vitellogenins are widespread phylogenetically, and their molecular behavior is essential for fitness traits in many animals.

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“…37. Centrifugations were 5 min at 2,000 ϫ g in room temperature, and the wash volume was 0.5 ml of PBS, if not specified otherwise.…”

Section: Methodsmentioning

confidence: 99%

Vitellogenin Recognizes Cell Damage through Membrane Binding and Shields Living Cells from Reactive Oxygen Species

Havukainen

Münch

Baumann

et al. 2013

Journal of Biological Chemistry

106

120

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“…This lipoprotein has a broad-range of antibacterial, antiviral, and antifungal effects as shown in several fish species [38][39][40][41] . Piscine vitellogenin gene expression is upregulated upon infection -the protein recognizes bacterial and fungal surface components, and facilitates phagocytosis of the pathogens [38] .…”

Section: Vitellogenin In Immunitymentioning

confidence: 99%

“…Added to this, vitellogenin, perhaps, has a special contribution. Most egg-laying animals express this immunomodulatory protein only during egg-yolk formation or as a response to immune activation with certain time-delay as observed in fish [53] . Contrary to this, vitellogenin is constantly present at high levels in the tissues of the long-lived individuals in social insects.…”

Section: Vitellogenin In Immunitymentioning

confidence: 99%

Vitellogenin in inflammation and immunity in social insects

2017

Inflamm Cell Signal

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Social insects, such as the honey bee and ants, form vast colonies that are only rivalled by human settlements. Living in dense, often stationary groups is prone to increase disease transmission. Yet, social insect queens and certain worker types can lead lengthy lives compared to the life span of most solitary insects. Social insects appear to have modified insulin/insulin like signaling pathway that regulates insect life history. This modification results in extremely elevated levels of the multifunctional lipoprotein vitellogenin in the individuals with longer life span. Vitellogenin is an egg-yolk precursor, but it also regulates caste-related behaviors in social insects, has shielding effects in inflammation and infection, and it is a mediator of transgenerational immunity. Here, we compile what is known about the life span and immune actions of vitellogenin and the evolution of this protein in the honey bee and ants. Recently we identified proteins homologous to vitellogenin in several Hymenopteran species, and showed that at least one of these vitellogenin-like proteins can have a protective role similar to vitellogenin in the honey bee. The newly identified vitellogenin homologs hint that the regulation of social insect life span can be more complex than thought before.

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“…However, this does not explain the higher Vg--like protein concentrations in males since only during the resting stages of gonadal development would ALP levels in females be similar to males (Blaise et al 1999;Matozzo et al, 2008;Porte et al 2006) which is indicative of the presence of EDCs. On the other hand, different studies have pointed out that vitellogenin is also an immune--relevant molecule with a potential role in defence reac--tions, possessing antibacterial and hemagglutinating activities (Shi et al, 2006;Tong et al, 2010;Zhang et al, 2005). This can also be an explanation to the presence of Vg in adult males and to the simi--larity of ALP levels between males and females, although suggest--ing that the organism's defence system is responsive to external agents more critical during summer.…”

Section: Biomarkers Indicesmentioning

confidence: 99%

A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

Cravo

Pereira

Gomes

et al. 2012

Marine Environmental Research

104

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Vitellogenin is an acute phase protein with bacterial-binding and inhibiting activities

Cited by 66 publications

References 24 publications

Vitellogenin Recognizes Cell Damage through Membrane Binding and Shields Living Cells from Reactive Oxygen Species

Vitellogenin Recognizes Cell Damage through Membrane Binding and Shields Living Cells from Reactive Oxygen Species

Vitellogenin in inflammation and immunity in social insects

A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

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