Vitamins, Sulfonamides and Antibiotics in Periodontal Therapy

Ostrander, F.D.

doi:10.14219/jada.archive.1948.0193

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…With the new‐found appreciation of the potential role of microbiome in RA, it is all the more plausible that improvement in the disease with antibiotic drugs could partly be caused by their antimicrobial properties. In addition, it is also worthwhile to note that tetracyclines and sulfonamides are effective against periodontal pathogens . That this could partly account for its benefit in RA is not clearly known.…”

Section: Antimicrobials and Ramentioning

confidence: 99%

Does the buck stop with the bugs?: an overview of microbial dysbiosis in rheumatoid arthritis

et al. 2015

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The human body is an environmental niche which is home to diverse co-habiting microbes collectively referred as the human microbiome. Recent years have seen the in-depth characterization of the human microbiome and associations with diseases. Linking of the composition or number of the human microbiota with diseases and traits date back to the original work of Elie Metchnikoff. Recent advances in genomic technologies have opened up finer details and dynamics of this new science with higher precision. Microbe-rheumatoid arthritis connection, largely related to the gut and oral microbiomes, has showed up as a result -apart from several other earlier, well-studied candidate autoimmune diseases. Although evidence favouring roles of specific microbial species, including Porphyromonas, Prevotella and Leptotricha, has become clearer, mechanistic insights still continue to be enigmatic. Manipulating the microbes by traditional dietary modifications, probiotics, and antibiotics and by currently employed disease-modifying agents seems to modulate the disease process and its progression. In the present review, we appraise the existing information as well as the gaps in knowledge in this challenging field. We also discuss the future directions for potential clinical applications, including prevention and management of rheumatoid arthritis using microbial modifications.

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Section: Antimicrobials and Ramentioning

confidence: 99%

Does the buck stop with the bugs?: an overview of microbial dysbiosis in rheumatoid arthritis

et al. 2015

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“…Noteworthy, some bacteria were even shown to invade periodontal soft tissue cells [ 19 – 21 ], where they remain inaccessible for conventional mechanical debridement as well. Therefore, antibiotic therapy has gained a long tradition in periodontitis therapy [ 22 ]. However, well-controlled studies are limited to specific agents [ 23 ], among which, amoxicillin, metronidazole and their combination being the most frequently investigated antibiotics [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

An estimate of pocket closure and avoided needs of surgery after scaling and root planing with systemic antibiotics: a systematic review

et al. 2014

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BackgroundRelevant benefits of adjunctive medication of antibiotica after conventional root surface debridement in terms of enhanced pocket depth (PD) reduction have been shown. However, means and standard deviations of enhanced reductions are difficult to translate into clinical relevant treatment outcomes such as pocket resolution or avoidance of additional surgical interventions. Accordingly, the aim of this systematic review was to calculate odds ratios for relevant cut-off values of PD after mechanical periodontal treatment with and without antibiotics, specifically the combination of amoxicilline and metronidazol, from published studies. As clinical relevant cut-off values “pocket closure” for PD ≤ 3mm and “avoidance of surgical intervention” for PD ≤ 5 mm were determined.MethodsThe databases PubMed, Embase and Central were searched for randomized clinical studies assessing the beneficial effect of the combination of amoxicillin and metronidazole after non-surgical mechanical debridement. Titles, abstracts and finally full texts were scrutinized for possible inclusion by two independent investigators. Quality and heterogeneity of the studies were assessed and the study designs were examined. From published means and standard deviations for PD after therapy, odds ratios for the clinically relevant cut-off values were calculated using a specific statistical approach.ResultsMeta-analyses were performed for the time points 3 and 6 month after mechanical therapy. Generally, a pronounced chance for pocket closure from 3 to 6 months of healing was shown. The administration of antibiotics resulted in a 3.55 and 4.43 fold higher probability of pocket closure after 3 and 6 months as compared to mechanical therapy alone. However, as the estimated risk for residual pockets > 5 mm was 0 for both groups, no odds ratio could be calculated for persistent needs for surgery. Generally, studies showed a moderate to high quality and large heterogeneity regarding treatment protocol, dose of antibiotic medication and maintenance.ConclusionWith the performed statistical approach, a clear benefit in terms of an enhanced chance for pocket closure by co-administration of the combination of amoxicillin and metronidazole as an adjunct to non-surgical mechanical periodontal therapy has been shown. However, data calculation failed to show a benefit regarding the possible avoidance of surgical interventions.

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“…In the 1940s, sulphonamides, which are effective in treating various gram-negative and -positive bacteria, were used for the treatment of periodontal diseases [40].…”

Section: Sulfasalazinementioning

confidence: 99%

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

Öğrendik¹

2014

OJRA

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A significant association has been shown to exist between periodontitis and rheumatoid arthritis (RA) in observational studies. Some intervention studies have suggested that periodontal treatment can reduce serum inflammatory biomarkers such as C-reactive protein, or erythrocyte sedimentation rate. Serum antibodies to oral bacteria have been found at increased levels in RA patients. In addition, DNAs from these bacteria have been identified from samples of RA patients. Several antibiotics are effective on RA. Finally, oral bacteria are responsible for the etiology of RA.

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Vitamins, Sulfonamides and Antibiotics in Periodontal Therapy

Cited by 7 publications

References 12 publications

Does the buck stop with the bugs?: an overview of microbial dysbiosis in rheumatoid arthritis

Does the buck stop with the bugs?: an overview of microbial dysbiosis in rheumatoid arthritis

An estimate of pocket closure and avoided needs of surgery after scaling and root planing with systemic antibiotics: a systematic review

Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

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