Vitamins and Immunocompetence1

Panush, Richard S.; Delafuente, Jeffrey C.

doi:10.1159/000410265

Cited by 50 publications

(21 citation statements)

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“…Dietary -tocopherol supplementation has confirmed the importance of vitamin E on immunity in homeotherms, where it enhances both humoral and cellular defences, whilst vitamin E deficient diets have been related to reduced immune responses (Panush & Delafuente, 1985;Chandra, 1988;Tengerdy, 1990). In fish, enhanced immune function has also been demonstrated in response to elevated vitamin E levels in the diet; however, the results were somewhat di#erent when analysing the vitamin E e#ect on the phagocytic and killing abilities of macrophages (Blazer & Wolke, 1984;Blazer et al, 1989;Hardie et al, 1990;Verlhac et al, 1993;Wise et al, 1993a,b;Pulsford et al, 1995).…”

Section: Introductionmentioning

confidence: 95%

Dietary vitamin E and rainbow trout (Oncorhynchus mykiss) phagocyte functions: effect on gut and on head kidney leucocytes

Clerton

Troutaud

Verlhac

et al. 2001

Fish & Shellfish Immunology

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Section: Introductionmentioning

confidence: 95%

Dietary vitamin E and rainbow trout (Oncorhynchus mykiss) phagocyte functions: effect on gut and on head kidney leucocytes

Clerton

Troutaud

Verlhac

et al. 2001

Fish & Shellfish Immunology

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“…In the metabolism, vitamin C is involved in collagen and catecholamine synthesis as a cofactor, it regulates steroid hormone synthesis, and is a water-soluble reduction-oxidation molecule as well as a modulator of the hexose monophosphate shunt [3]. Since it was demonstrated that the ascorbic acid content of human leucocytes was 10-40 times higher than that of blood serum and that this content decreased during bacterial infections, vitamin C has been linked to the immune system function …”

Section: Discussionmentioning

confidence: 99%

“…Its depletion in the diet causes scurvy, which is cured when vitamin C intake is restored. Ascorbic acid plays an important role in the metabolism due to its antioxidant properties and, among its pharmacological uses in humans, it has been used to treat cancer as well as some other diseases and infections [3]. The importance of vitamin C was linked to the *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Natural cytotoxic activity in seabream (Sparus aurata L.) and its modulation by vitamin C

Cuesta

Meseguer

2002

Fish & Shellfish Immunology

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“…The presence or the absence of certain vitamins and nutrients can affect immune responses (82)(83)(84)(85). Addition of vitamins C and E to food has been shown to stimulate immune responses, and suppressed immune responses have been observed associated with deficiency of vitamins A, B, and E. Immune responses are also affected by iron and zinc deficiencies.…”

Section: Nutrition and Efficacy Of Vaccinationmentioning

confidence: 99%

Vaccine-Induced Antibody Responses as Parameters of the Influence of Endogenous and Environmental Factors

Loveren¹,

Amsterdam²,

Vandebriel³

et al. 2001

Environmental Health Perspectives

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In laboratory animals, an adequate way to assess effects of environmental exposures on the immune system is to study effects on antigen-specific immune responses, such as after sensitization to T-cell-dependent antigens. This probably also applies to testing effects in the human population. It has thus been suggested that antibody responses to vaccination might be useful in this context. Vaccination responses may be influenced by a variety of factors other than environmental ones. One factor is the vaccine itself; a second is the vaccination procedure used. In addition, the intrinsic capacity of the recipient to respond to a vaccine, which is determined by sex, genetic factors, and age, is important. Psychological stress, nutrition, and (infectious) diseases are also likely to have an impact. We reviewed the literature on vaccine response. With regard to exogenous factors, there is good evidence that smoking, diet, psychological stress, and certain infectious diseases affect vaccination titers, although it is difficult to determine to what extent. Genetic factors render certain individuals nonresponsive to vaccination. In general, in epidemiologic studies of adverse effects of exposure to agents in the environment in which vaccination titers are used, these additional factors need to be taken into consideration. Provided that these factors are corrected for, a study that shows an association of exposure to a given agent with diminished vaccination responses may indicate suboptimal function of the immune system and clinically relevant diminished immune response. It is quite unlikely that environmental exposures that affect responses to vaccination may in fact abrogate protection to the specific pathogen for which vaccination was performed. Only in those cases where individuals have a poor response to the vaccine may exogenous factors perhaps have a clinically significant influence on resistance to the specific pathogen. An exposure-associated inhibition of a vaccination response may, however, signify a decreased host resistance to pathogens against which no vaccination had been performed.

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Vitamins and Immunocompetence1

Cited by 50 publications

References 0 publications

Dietary vitamin E and rainbow trout (Oncorhynchus mykiss) phagocyte functions: effect on gut and on head kidney leucocytes

Dietary vitamin E and rainbow trout (Oncorhynchus mykiss) phagocyte functions: effect on gut and on head kidney leucocytes

Natural cytotoxic activity in seabream (Sparus aurata L.) and its modulation by vitamin C

Vaccine-Induced Antibody Responses as Parameters of the Influence of Endogenous and Environmental Factors

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