Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies

Redeuil, Karine; Lévêques, Antoine; Oberson, Jean‐Marie; Bénet, Sylvie; Tissot, Emeline; Longet, Karin; Castro, Antonio de; Romagny, Céline; Beauport, Lydie; Fumeaux, Céline J. Fischer; Tolsa, Jean-François; Affolter, Michael; Giménez, Esther; García-Ródenas, Clara L.; Thakkar, Sagar K.

doi:10.1016/j.clnu.2020.05.012

Cited by 18 publications

(10 citation statements)

References 22 publications

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“…In this study, we described the effects of dietary patterns on the xanthophyll profiles in the human milk of the Japanese population. The results showed that the xanthophyll concentrations were comparable to a series of recent results from mature milk studies ( 7 , 15 , 17 , 19–22 , 31 ). Our study showed high median lutein and zeaxanthin concentrations in mature milk ( Supplemental Table 4 ; 65.6 ng/mL vs. 22–65 ng/mL for lutein, 18.5 ng/mL vs. 8–17 ng/mL for zeaxanthin).…”

Section: Discussionsupporting

confidence: 85%

“…Humans cannot synthesize carotenoids de novo; thus, the intake of carotenoids is dependent on the diet. Dietary carotenoids vary among individuals, and their bioavailability is influenced by the nature of each molecule, other dietary factors, and their food matrices ( 7 , 8 ). Xanthophylls are oxidation products of carotenes, which is 1 of the 2 classes of carotenoids.…”

Section: Introductionmentioning

confidence: 99%

“…The natural variation in human milk xanthophylls is influenced by dietary, sociodemographic, and health factors. The concentration of xanthophylls in human milk varies according to the lactation stage ( 15 , 16 ), delivery mode ( 17 ), gestational period ( 7 ), and maternal diet ( 18–20 ). Xanthophyll concentrations in human milk are high in Japan (0.157 nmol/L) and China (0.111 nmol/L) but low in the United States (0.038 nmol/L) and Philippines (0.047 nmol/L) ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

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Xanthophylls in Human Milk and Maternal Diet: A Cross-sectional Analysis of Data from the Japanese Human Milk Study Cohort

Ueno

Sato

Higurashi

et al. 2022

Current Developments in Nutrition

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Background Maternal diet and sociodemographic factors influence xanthophyll concentration and composition in human milk. However, the importance of dietary patterns regarding the intake of fruits, vegetables and xanthophylls remains unclear. Objective To determine the composition of xanthophylls in the human milk of Japanese mothers and explore associations of xanthophylls with dietary and sociodemographic factors. Methods This cross-sectional study was conducted in the early phase of the Japanese Human Milk Study. Xanthophyll content was measured using liquid chromatography at 30–36 days postpartum. Maternal intake of foods, nutrients, and dietary supplements was estimated using a food frequency questionnaire. Linear regression models were established using xanthophylls, maternal diet, and sociodemographic factors. Results Xanthophyll concentrations were measured in human milk from 118 mothers. The xanthophyll concentration varied among individuals. The median (interquartile range) concentrations of lutein, zeaxanthin, and β-cryptoxanthin were 65.6 ng/mL (51.6–103.4 ng/mL), 18.6 ng/mL (12.9–25.8 ng/mL), and 15.6 ng/mL (9.0–26.0 ng/mL), respectively. In multivariate models, the lutein concentration was associated independently with dietary green vegetables, exclusive breastfeeding, and education (r2 = 0.153 for the model; β ± standard error [SE]: 0.468 ± 0.198, 25.048 ± 10.222, and 13.460 ± 6.774; standardized β = 0.210, 0.217, and 0.175; P = 0.019, 0.016, and 0.049 for dietary green vegetables, exclusive breastfeeding, and education, respectively). For zeaxanthin, exclusive breastfeeding was the most appropriate predictor (r2 = 0.085; β ± SE: 7.811 ± 3.300; standardized β = 0.218; P = 0.020). The highest predictive power for human milk β-cryptoxanthin was obtained with dietary β-cryptoxanthin (r2 = 0.258; β ± SE: 0.089 ± 0.015; standardized β = 0.468; P<0.001), attributed to maternal citrus intake. Conclusions β-Cryptoxanthin in human milk was the xanthophyll most influenced by the maternal diet in Japanese women. The β-cryptoxanthin concentration in human milk was reflected by the maternal β-cryptoxanthin intake, mainly attributed to Japanese citrus consumption. Clinical trial registration: UMIN000015494

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Xanthophylls in Human Milk and Maternal Diet: A Cross-sectional Analysis of Data from the Japanese Human Milk Study Cohort

Ueno

Sato

Higurashi

et al. 2022

Current Developments in Nutrition

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“…Redeuil and colleagues compared human milk at equivalent post-partum ages and assessed for concentrations of vitamins. When compared at equivalent post-menstrual age, preterm maternal milk was significantly higher for vitamins B1, B2, B3, B6 and B9 and also had lower concentrations of vitamins A, E, beta-carotene, beta-cryptoxanthin and lutein when compared to term milk [ 57 ]. Similarly, in our analysis, we identified a significantly increased concentration of pyridoxate, a vitamin B6 metabolite, and beta-cryptoxanthin, a carotenoid, in the milk of mothers with preterm control infants with a birth weight of ≤1.0 kg.…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants

et al. 2021

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The application of metabolomics in neonatology offers an approach to investigate the complex relationship between nutrition and infant health. Characterization of the metabolome of human milk enables an investigation into nutrients that affect the neonatal metabolism and identification of dietary interventions for infants at risk of diseases such as necrotizing enterocolitis (NEC). In this study, we aimed to identify differences in the metabolome of breast milk of 48 mothers with preterm infants with NEC and non-NEC healthy controls. A minimum significant difference was observed in the human milk metabolome between the mothers of infants with NEC and mothers of healthy control infants. However, significant differences in the metabolome related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins and oxidative stress-related metabolites were observed when comparing milk from mothers with control infants of ≤1.0 kg birth weight and >1.5 kg birth weight. Understanding the functional biological features of mothers’ milk that may modulate infant health is important in the future of tailored nutrition and care of the preterm newborn.

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“…Preterm infants, in particular, are at high risk of vitamin deficiencies due to limited stores at birth, as well as to increased needs related to their rapid growth and development. To the best of our knowledge, there is very scarce data on B vitamins in preterm human milk [56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

NMR Metabonomic Profile of Preterm Human Milk in the First Month of Lactation: From Extreme to Moderate Prematurity

Peila

Sottemano

Marincola

et al. 2022

Foods

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Understanding the composition of human milk (HM) can provide important insights into the links between infant nutrition, health, and development. In the present work, we have longitudinally investigated the metabolome of milk from 36 women delivering preterm at different gestational ages (GA): extremely (<28 weeks GA), very (29–31 weeks GA) or moderate (32–34 weeks GA) premature. Milk samples were collected at three lactation stages: colostrum (3–6 days post-partum), transitional milk (7–15 days post-partum) and mature milk (16–26 days post-partum). Multivariate and univariate statistical data analyses were performed on the 1H NMR metabolic profiles of specimens in relation to the degree of prematurity and lactation stage. We observed a high impact of both the mother’s phenotype and lactation time on HM metabolome composition. Furthermore, statistically significant differences, although weak, were observed in terms of GA when comparing extremely and moderately preterm milk. Overall, our study provides new insights into preterm HM metabolome composition that may help to optimize feeding of preterm newborns, and thus improve the postnatal growth and later health outcomes of these fragile patients.

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Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies

Cited by 18 publications

References 22 publications

Xanthophylls in Human Milk and Maternal Diet: A Cross-sectional Analysis of Data from the Japanese Human Milk Study Cohort

Xanthophylls in Human Milk and Maternal Diet: A Cross-sectional Analysis of Data from the Japanese Human Milk Study Cohort

Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants

NMR Metabonomic Profile of Preterm Human Milk in the First Month of Lactation: From Extreme to Moderate Prematurity

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