Vitamins, 9. Vitamin B5

Müller, Marc-André; Medlock, Jonathan; Prágai, Zoltán; Warnke, Ines; Litta, Gilberto; Kleefeldt, Andreas; Kaiser, Klaus; Potzolli, Bernd

doi:10.1002/14356007.o27_o11.pub2

Cited by 4 publications

(11 citation statements)

References 102 publications

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“…Another solid form of pantothenic acid is sodium pantothenate. Its use, however, is limited due to its hygroscopicity [ 69 , 415 , 671 , 672 , 673 ].…”

Section: Pantothenic Acid—vitamin Bmentioning

confidence: 99%

“…The biosynthesis of pantothenic acid occurs in plants, fungi, and most bacteria. The human or animal organism as well as some bacteria lack the capability to synthesize this vitamin and, therefore, they are dependent on its exogenous supply [ 14 , 423 , 431 , 540 , 671 , 672 , 674 , 675 , 676 , 677 , 678 , 679 , 680 , 681 , 682 , 683 , 684 , 685 , 686 ]. In the human diet, pantothenic acid is ubiquitous and is widely distributed in foods of both plant and animal origin.…”

Section: Pantothenic Acid—vitamin Bmentioning

confidence: 99%

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Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

et al. 2022

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This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5. These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can also be synthetized from amino acid tryptophan. All of these vitamins are water soluble, which determines their main properties, namely: they are partly lost when food is washed or boiled since they migrate to the water; the requirement of membrane transporters for their permeation into the cells; and their safety since any excess is rapidly eliminated via the kidney. The therapeutic use of B-complex vitamins is mostly limited to hypovitaminoses or similar conditions, but, as they are generally very safe, they have also been examined in other pathological conditions. Nicotinic acid, a form of vitamin B3, is the only exception because it is a known hypolipidemic agent in gram doses. The article also sums up: (i) the current methods for detection of the vitamins of the B-complex in biological fluids; (ii) the food and other sources of these vitamins including the effect of common processing and storage methods on their content; and (iii) their physiological function.

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“…Another solid form of pantothenic acid is sodium pantothenate. Its use, however, is limited due to its hygroscopicity [ 69 , 415 , 671 , 672 , 673 ].…”

Section: Pantothenic Acid—vitamin Bmentioning

confidence: 99%

Section: Pantothenic Acid—vitamin Bmentioning

confidence: 99%

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

et al. 2022

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“…Efficient method to synthesize highly enantiomerically pure (R)pantolactone, i. e. (R)-4,5-dihyhydro-3-hydroxy-4,4-dimethylfuran-2-(3H)one, has always been an intensive research object since its first successful preparation in 1940 by Stiller and coworkers. [1] It is the direct synthetic precursor of calcium pantothenate, also named as vitamin B5, [2] provitamin (R)pantothenol, also used as a bactericide, [3] and (R)-pantotheine, a growth factor. [4] (R)-pantothenic acid is the constituent of coenzyme A.…”

Section: Introductionmentioning

confidence: 99%

“…[4] (R)-pantothenic acid is the constituent of coenzyme A. [2] In addition, (R)-pantolactone was similarly used as the chiral auxiliary [5] and the chiral starting material for organic synthesis of bioactive compounds. [6] At present, (R)pantolactone has been broadly utilized as ingredients of pharmaceutical and cosmetic products, and as additives of food and feed.…”

Section: Introductionmentioning

confidence: 99%

“…The conventional method to synthesize racemic pantolactone constitutes a multistep procedure involving aldol reaction between isobutyr-aldehyde and formaldehyde, subsequent hydrocyanation with HCN, and the last acidic one-pot saponification and lactonization. [2] This procedure is broadly adopted in industries because of cheap starting materials despite long steps. Using racemic pantolactone as starting materials, main works are focused on the asymmetric resolution.…”

Section: Introductionmentioning

confidence: 99%

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Organocatalyzed Highly Enantioselective Aldol Reaction of Aldehydes for Synthesis of (R)‐Pantolactone

Yuan

Tao

et al. 2021

Asian J Org Chem

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This work demonstrates that a tert-leucine-derived 2-phenolic anilide is the efficient organocatalyst to catalyze the asymmetric cross-aldol reaction of glyoxylate and alkyl aldehydes in high yield and enantioselectivity at room temperature. As compared to the reported simple primary amino acids, the 2-phenolic anilide can produce two hydrogen bonds from its phenolic hydroxy and amide groups with aldehyde moiety of ethyl glyoxylate, greatly enhancing the electrophilicity of ethyl glyoxylate and effectively increasing the asymmetric induction of the aldol reaction. Additionally, the large side group-bearing tert-leucine is also essential to high enantioselectivity. The reaction was successfully performed on 50 mmol scale with no decrease in the yield and enantioselectivity, showing potential for the chemical production of the pharmaceutical intermediate (R)-pantolactone with high yield and enantiopurity in an eco-friendly method.

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Natural and Plant-Derived Vitamins: A Comprehensive Review of Biochemistry, Pharmacology and Nutritional Benefits in Health and Disease

Singh,

Kaur,

Singh

et al. 2024

Advances in Biochemistry in Health and Disease

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Vitamins, 9. Vitamin B5

Cited by 4 publications

References 102 publications

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

Organocatalyzed Highly Enantioselective Aldol Reaction of Aldehydes for Synthesis of (R)‐Pantolactone

Natural and Plant-Derived Vitamins: A Comprehensive Review of Biochemistry, Pharmacology and Nutritional Benefits in Health and Disease

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