Vitaminï¿½D and DDX4 regulate the proliferation and invasion of ovarian cancer cells

Chen, Youguo; Sun, Ziqian; Xu, Jiahua; Wang, Peifang; Tang, Juan; Shi, Xiaorui; Liu, Jingjing; Ren, Fangfang; Xu, Lan

doi:10.3892/ol.2018.8718

Cited by 9 publications

(28 citation statements)

References 19 publications

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“…As for DDX4, it presents in gonadal germ cells in both fetal and adult. DDX4 is abundant mostly in mature, as known, oocytes and spermatocytes and play a vital role in germ line cells development in ovary [ 52 ]. VEGFA is essential for both physiological and pathological angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Feng

Tan

2018

Stem Cell Rev and Rep

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POI is characterized by “absent not abnormal” menstruation with hormonal disorders in woman younger than 40 years of age, and etiological and pathophysiological mechanisms underlying the POI development have not been clearly defined. Recently, due to advantages such as abundant sources and non-invasive methods of harvest, MenSCs have been emerging as a promising treatment strategy for the recovery of female reproductive damage. Here, we demonstrated that MenSCs graft in POI mice after CTX treatment could restore ovarian function by regulating normal follicle development and estrous cycle, reducing apoptosis in ovaries to maintain homeostasis of microenvironment and modulating serum sex hormones to a relatively normal status. Moreover, MenSCs participated in the activation of ovarian transcriptional expression in ECM-dependent FAK/AKT signaling pathway and thus restored ovarian function to a certain extent. MenSCs transplantation was proved to be an effective way to repair ovarian function with low immunogenicity, suggesting its great potential for POI treatment. Electronic supplementary material The online version of this article (10.1007/s12015-018-9867-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Feng

Tan

2018

Stem Cell Rev and Rep

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Section: Epithelial-mesenchymal Transition and Cancer Progressionmentioning

confidence: 99%

“…DDX4 (DEAD (Asp-Glu-Ala-Asp)-box helicase 4) has been found to be another target for active vitamin D [49]. Treatment with active vitamin D reduced the expression of DDX which inhibited the invasion of ovarian cancer cells [49]. Microarray studies have identified a number of target genes involved in tumour growth and progression regulated by 1,25(OH) 2 D. The upregulation of lysophosphatidic acid G-protein coupled receptor (Edg2) is consistent with its function in the inhibition of tumour growth.…”

Section: Epithelial-mesenchymal Transition and Cancer Progressionmentioning

confidence: 99%

Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms

Dovnik

2020

Cells

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Vitamin D is a lipid soluble vitamin involved primarily in calcium metabolism. Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell.

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“…7 As an immune modulator, vitamin D3 has been found to be a factor in the prevention and mitigation of several forms of cancer including breast, ovarian, colorectal, oral, small-cell lung and prostate cancers. [8][9][10][11][12][13][14][15][16][17][18][19][20] The emerging evidence for the therapeutic use of vitamin D in the treatment of cancer warrants attention. 11,19,21,22 Cancer costs across the world are inestimable, and not all countries can afford to test and treat for the multiple cancers arising within the population.…”

Section: Introductionmentioning

confidence: 99%

Prescribing patterns of vitamin D and analogues in a private healthcare patient population in South Africa

Morris-Paxton

Truter

2020

South African Journal of Clinical Nutrition

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Numerous studies show the benefits of vitamin D: in the prevention of bone disease, supporting the immune system and the prevention and mitigation of cancer. Until recently, supplementation has been deemed unnecessary. Nonetheless, in the light of emerging evidence, some practitioners are adding vitamin D and its analogues (Anatomic Therapeutic Chemical (ATC) classification code A11CC) to their prescriptions. Therefore, the aim was to determine the medical insurance prescribing patterns of vitamin D in South Africa. Methods: A retrospective, cross-sectional drug utilisation study was conducted on a South African medical insurance administrator database for 2018. Products in ATC subgroup A11CC (vitamin D and analogues) were extracted and analysed. Results: A total of 302 patients received 1 164 prescriptions for a vitamin D or analogue product during 2018. The average age of patients was 47.14 (SD = 24.03) years, and the majority were female (58.28%). Very young patients and middle-aged patients received most of the prescriptions. Ergocalciferol (A11CC01) was the most frequently prescribed (59.79%), followed by alfacalcidol (A11CC), colecalciferol (A11CC05) and calcitriol (A11CC04). Ergocalciferol 50 000 IU tablets comprised the most frequently prescribed trade name product (59.45%), followed by alfacalcidol capsules (21.31%). Conclusion: Vitamin D was used across the age range. Vitamin D supplementation was primarily prescribed in the very young and older age groups, suggesting their need for additional supplementation. As the cost of additional supplements is relatively small compared with the treatment of deficiency disorders, vitamin D supplementation could have broad and positive effects on long-term health for very little outlay.

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Vitaminï¿½D and DDX4 regulate the proliferation and invasion of ovarian cancer cells

Cited by 9 publications

References 19 publications

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Human Menstrual Blood-Derived Stromal Cells Promote Recovery of Premature Ovarian Insufficiency Via Regulating the ECM-Dependent FAK/AKT Signaling

Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms

Prescribing patterns of vitamin D and analogues in a private healthcare patient population in South Africa

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