Vitamin supplementation for preventing miscarriage

Balogun, Olukunmi Omobolanle; Lopes, Katharina da Silva; Ota, Erika; Takemoto, Yo; Rumbold, Alice; Takegata, Mizuki; Mori, Rintaro

doi:10.1002/14651858.cd004073.pub4

Cited by 60 publications

(55 citation statements)

References 216 publications

(12 reference statements)

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“…Such findings substantiate the provocative contention that VitE also is a nutrient of similar status and significance, both for the fetal brain and for long-term cognitive function, and provide evidence to encourage future reevaluation of recommended VitE intake levels to promote optimal neurodevelopment and cognitive health in humans. Currently, there is only limited information available on the role of VitE in miscarriage [2,65] and cognitive function [66,67] in humans. Clearly, more research is needed in this area.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets

McDougall

Choi

Truong

et al. 2017

Free Radical Biology and Medicine

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Vitamin E (α-tocopherol; VitE) is a lipophilic antioxidant required for normal embryonic development in vertebrates, but the long-term effects of embryonic VitE deficiency, and whether they are ameliorated by feeding VitE−adequate diets, remain unknown. We addressed these questions using a zebrafish (Danio rerio) model of developmental VitE deficiency followed by dietary remediation. Adult zebrafish maintained on VitE−deficient (E−) or sufficient (E+) diets were spawned to obtained E− and E+ embryos, respectively, which we evaluated up to 12 days post-fertilization (dpf). The E− group suffered significantly increased morbidity and mortality as well as altered DNA methylation status through 5 dpf when compared to E+ larvae, but upon feeding with a VitE-adequate diet from 5–12 dpf both the E− and E+ groups survived and grew normally; the DNA methylation profile also was similar between groups by 12 dpf. However, 12 dpf E− larvae still had behavioral defects. These observations coincided with sustained VitE deficiency in the E− vs. E+ larvae (p< 0.0001), despite adequate dietary supplementation. We also found in E− vs. E+ larvae continued docosahexaenoic acid (DHA) depletion (p< 0.0001) and significantly increased lipid peroxidation. Further, targeted metabolomics analyses revealed persistent dysregulation of the cellular antioxidant network, the CDP-choline pathway, and glucose metabolism. While anaerobic processes were increased, aerobic metabolism was decreased in the E− vs. E+ larvae, indicating mitochondrial damage. Taken together, these outcomes suggest embryonic VitE deficiency causes lasting behavioral impairments due to persistent lipid peroxidation and metabolic perturbations that are not resolved via later dietary VitE supplementation.

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Section: Discussionmentioning

confidence: 99%

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets

McDougall

Choi

Truong

et al. 2017

Free Radical Biology and Medicine

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“…Another review demonstrated that the risk of pre-eclampsia, low birthweight, and preterm birth may be reduced by vitamin D supplementation during pregnancy [14]. Evidence also exists that links multivitamin supplementation with iron and folic acid to reduce the risk of miscarriage [15].…”

Section: Introductionmentioning

confidence: 99%

Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

et al. 2020

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Pregnancy in adolescence and malnutrition are common challenges in low- and middle-income countries (LMICs), and are associated with many complications and comorbidities. The preconception period is an ideal period for intervention as a preventative tactic for teenage pregnancy, and to increase micronutrient supplementation prior to conception. Over twenty databases and websites were searched and 45 randomized controlled trials (RCTs) or quasi-experimental interventions with intent to delay the age at first pregnancy (n = 26), to optimize inter-pregnancy intervals (n = 4), and supplementation of folic acid (n = 5) or a combination of iron and folic acid (n = 10) during the periconception period were included. The review found that educational interventions to delay the age at first pregnancy and optimizing inter-pregnancy intervals significantly improved the uptake of contraception use (RR = 1.71, 95% CI = 1.42–2.05; two studies, n = 911; I2 = 0%) and (RR = 2.25, 95% CI = 1.29–3.93; one study, n = 338), respectively. For periconceptional folic acid supplementation, the incidence of neural tube defects were reduced (RR = 0.53; 95% CI = 0.41–0.77; two studies, n = 248,056; I2 = 0%), and iron-folic acid supplementation improved the rates of anemia (RR = 0.66, 95% CI = 0.53–0.81; six studies; n = 3430, I2 = 88%), particularly when supplemented weekly and in a school setting. Notwithstanding the findings, more robust RCTs are required from LMICs to further support the evidence.

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“…In an effort to address potential individual micronutrient deficiencies, many women take complex pregnancy multivitamins. Despite high‐frequency use and widespread marketing and promotion, there is a lack of evidence that routine supplementation with multivitamins or supplements containing multiple micronutrients either in pre‐ or periconception is beneficial to pregnancy outcome . In many cases, supplementation with such multivitamins may provide amounts of various vitamins and minerals above what is actually needed.…”

Section: Use Of Multivitaminsmentioning

confidence: 99%

Vitamin and mineral supplementation in pregnancy: evidence to practice

Wilson

Gummow

McAninch

et al. 2018

Pharmacy Practice and Res

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Pregnancy is a dynamic state that requires increased nutrient intakes in order to support the growing fetus, placenta and maternal tissues, and hence a successful pregnancy outcome. Although maternal micronutrient deficiencies during pregnancy are often associated with pregnancy complications, as well as adverse fetal growth and development, evidence to support routine vitamin and mineral supplementation is relatively scarce. This review summarises existing evidence and special considerations regarding folic acid, vitamin B12, vitamin D, calcium, zinc, iron, selenium and iodine supplementation on pregnancy outcomes. Current practice recommendations are for routine supplementation of folic acid and iodine, but recommendations regarding other vitamins and minerals are based on an individualised approach in pregnancy, with supplementation restricted to women with insufficient dietary intakes or established deficiencies. This review aims to support pharmacists in evaluating the appropriateness of various individual and multicomponent vitamin and mineral supplements and providing balanced and up‐to‐date information to women who are either planning pregnancy or are already pregnant.

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Vitamin supplementation for preventing miscarriage

Cited by 60 publications

References 216 publications

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets

Effects of Preconception Care and Periconception Interventions on Maternal Nutritional Status and Birth Outcomes in Low- and Middle-Income Countries: A Systematic Review

Vitamin and mineral supplementation in pregnancy: evidence to practice

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