Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study

Abstract

Objective: The influence of vitamin supplements on risk for breast cancer is unclear. Also the interactive effects of vitamins from dietary and supplemental sources are unknown. This study investigated the association between self-reported vitamin supplement use (A, B, C, E and multivitamin) and breast cancer among urban Chinese women. It also examined the combined effect of vitamin supplements in relation to particular dietary vitamin intakes on breast cancer risk.Methods: Study subjects were identified from The Shanghai Breast Cancer Study (SBCS) and was a population-based case-control study conducted in Shanghai in 1996-1998 (Phase I) and 2002-2004. Participants were aged 25 to 64 and 20 to 70 years for phase I and for phase II, respectively. The analyses included 3,454 incident breast cancer cases and 3,474 controls. Unconditional logistic regression models were used to determine adjusted odds ratios (ORs) for breast cancer risk associated with vitamin supplement use.Results: Overall, the breast cancer risk was not related to intakes of any vitamin supplement. However, an approximately 20% reduction in breast cancer risk was observed with use of vitamin E supplement among women with low-dietary vitamin E intake (OR=0.8; 95% confidence interval (CI), 0.6-0.9) with a significant does-response inverse association (P trend =0.01 for duration). Modest risk reduction was observed among vitamin B supplement users with low dietary intake of the same vitamin (OR=0.9; 95% CI, 0.6-1.0). However, vitamin B supplement was adversely associated with breast cancer risk among those with high dietary vitamin B intake with a significant dose-response effect (P trend =0.04 for duration).Conclusions: This study suggests that vitamins E and B supplement may confer a prevention of breast cancer among women who have low dietary intake of those vitamins.

Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression

“…Maybe vitamin E has an effect only in Fig. 3 The funnel plots for the associations between total retinol (a), total vitamin A (b), total vitamin C (c), total vitamin E (d), and breast cancer combination with other dietary components, such as polyunsaturated fatty acids [68], or that a vitamin E supplement may confer protection against breast cancer among women with insufficient dietary intake of vitamin E [18].…”

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“…Similar results were found in two case-control studies reported by Longnecker et al [40] and Rohan et al [38]. On the contrary, a case-control study by Dorjgochoo et al [44] found a not significant increased risk (OR = 1.20; 95% CI: 0.80–1.60) for the longest supplemental use.…”

“…In the Shanghai Breast Cancer Study, Dorjgochoo et al [44] evaluated the consumption of vitamin B1, B2, and niacin supplementation, but the results did not support a relationship with breast cancer incidence for the use of supplements (user versus non-user, duration, and frequency of supplementation).…”

Nutraceuticals and Nutraceutical Supplementation Criteria in Cancer: A Literature Survey

“…The major impact of experimental animal studies was distinct observations of reduced cancer cell growth by nutraceutical intervention and it supported the role of nutraceuticals in cancer prevention and treatment. The major examples of breast cancer preventive nutraceuticals are soy genestein [122][123][124], isoflavones, multivitamins as scavengers of free radicals, antioxidant, mitochondrial oxidative phosphorylation [125][126][127][128][129][130][131][132].…”

“…In other recent reports the investigators showed a positive response of different nutraceutical supplements and foods in cancer prevention of different organs in the body as shown in Table 3 with nutraceuticals and references. Bone cancer soy isoflavones [5] Breast cancer lycopene, phytoesterogen [122][123][124][125][126][127][128][129][130][131][132] Common cancer cruciferous vegetables [25,184] Colon cancer nuts, fibers [158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] Gastric cancer herbs [173][174][175] Intestinal cancer sphingolipids [64,65,176] Liver cancer silbinin, citrous flavonoids [25] Lung cancer vitamins A and E [154][155][156][157] Ovary cancer Vitamin A, D, antioxidants [176][177][178] Pancreatic cancer Vitamins and isoflavones …”