Vitamin status of patients with oral lichen planus

Jolly, Mark; Nobile, Silvia

doi:10.1111/j.1834-7819.1977.tb05148.x

Cited by 22 publications

(21 citation statements)

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“…Poor and delayed wound healing can result from an inadequate nutritional status, especially in elderly patients. Although vitamin deficiencies were not found to be greater in patients with oral lichen planus than in control subjects, correction of low levels of vitamin B { and B 6 resulted in clinical and subjective improvement in the majority of treated patients (Jolly and Nobile, 1977). Patients not only should try to maintain adequate dietary habits but also be instructed to avoid foods that they find cause pain and exacerbate their disease.…”

Section: Dietmentioning

confidence: 94%

The Therapy of Oral Lichen Planus

Eisen

1993

Critical Reviews in Oral Biology & Medicine

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Oral lichen planus is a chronic mucocutaneous disease that is relatively common. Although many patients are asymptomatic and require no therapy, those who exhibit atrophic and erosive lesions are often a challenge to treat. All therapies are palliative, and none is effective universally. Currently employed treatment modalities include corticosteroids administered topically, intralesionally, or systemically. Alternative therapies include topical and systemic retinoids, griseofulvin, Cyclosporine, and surgery. Other medical treatments and experimental modalities, including mouth PUVA, have been reported to be effective. Controversy concerning the efficacy of all these treatments suggests that oral lichen planus is a heterogeneous disorder. Eliminating lichenoid drug eruptions, candidiasis, trauma, contact mucositis, and emotional stress may play a role in the management of these patients. This article is a review of the many treatments and measures that have been employed in the management of patients with oral lichen planus.

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Section: Dietmentioning

confidence: 94%

The Therapy of Oral Lichen Planus

Eisen

1993

Critical Reviews in Oral Biology & Medicine

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“…Despite there being no evidence of a significant vitamin deficiency in OLP (Camisa and Allen, 1986), 71% using multivitamin supplements containing 10.000 IU of retinol showed some improvement of oral lesions (Jolly and Nobile, 1977). Kovesi and Banoczy (1973) treated 184 patients with vitamin A (50.000 IU) associated with vitamin B complex daily for 5 weeks.…”

Section: Systemic Retinoidsmentioning

confidence: 99%

The management of oral lichen planus

1999

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OBJECTIVE: To review the current literature regarding the medical treatment of oral lichen planus (OLP). DATA SOURCES: PubMed on‐line Medline data searches were carried out for the years 1966–1998 to identify reports on therapy of OLP. METHODS OF STUDY SELECTION: Single case reports or open trials were included if they covered new therapeutic approaches or suggested significant modifications of known treatment modalities. Review papers were limited to those dealing with the topic. DATA EXTRACTION AND SYNTHESIS: Every paper was critically examined. Because of the great heterogeneity of the response criteria, many data could not be directly compared. Stronger weight was given to therapies that have proven to be effective under placebo‐controlled research protocols. Attention was also drawn to potential and effective adverse effects of every drug used. CONCLUSIONS: Among the various medications advocated for the treatment of OLP, several lack conclusive findings from adequately controlled trials. Mainly high‐potency topical corticosteroids in an adhesive medium appear at present the safest and most efficacious. Adjuvant agents as antimycotics may be useful in topical steroid treatment. Systemic corticosteroids may be occasionally indicated for severe recalcitrant erosive OLP or for diffuse mucocutaneous involvement. Topical cyclo‐sporine should be considered in steroid‐unresponsive cases considering that its efficacy in OLP could be related to a systemic effect and its high cost. Classical PUVA therapy seems to have too many side effects; topical application of psoralen is promising but still experimental. Topically and systemically delivered retinoids combined with topical corticosteroids could improve the efficacy of these agents whereas complete remission is difficult to achieve with retinoids alone and they frequently cause adverse effects. Finally, there are only few data concerning the long‐term effect of the medical treatments upon the course of OLP and we do not know if therapy influences the malignant evolution of OLP.

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“…Based on our ndings, hematological screening for hematinic de ciencies should be included in routine laboratory examination of OLP patients. Several studies have proposed that vitamin replacement may improve the general health of OLP patients and increase their healing ability [12,36]. Therefore, compensation of hematinic de ciencies with adequate nutritional supplements or in combination with other drugs, is supposed to produce improved therapeutic effects on OLP patients [12,36].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have proposed that vitamin replacement may improve the general health of OLP patients and increase their healing ability [12,36]. Therefore, compensation of hematinic de ciencies with adequate nutritional supplements or in combination with other drugs, is supposed to produce improved therapeutic effects on OLP patients [12,36]. In addition, dietary assessment and guidance to maintain adequate nutrition and optimal quality of life should be considered as a component of OLP management [20,22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to affect the integrity of oral mucosa and increase the risk of secondary infection in oral cavity, hematinic de ciencies can also cause aberrant immune responses or contribute to psychological disorders, which may be involved in the pathogenesis of OLP [6][7][8][9][10][11]. However, the existing studies on the association between hematinic de ciencies and OLP have been lacking and the conclusions were inconsistent [12][13][14][15]. Wu et al proposed that OLP was one of the leading oral manifestations for iron de ciency anemia (IDA) patients and could be diagnosed in one-third patients with IDA in their oral mucosal disease clinic [16].…”

Section: Introductionmentioning

confidence: 99%

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The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

Bao

Yang

Shi

et al. 2020

Preprint

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Background: Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, and its causative factors and pathogenesis are not fully understood. Existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP.Methods: A total of 236 OLP patients and 226 age-and-gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. An REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed.Results: The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for the REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP.Conclusions: The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.

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Vitamin status of patients with oral lichen planus

Cited by 22 publications

References 0 publications

The Therapy of Oral Lichen Planus

The Therapy of Oral Lichen Planus

The management of oral lichen planus

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

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