Vitamin <scp>D</scp> intake and survival and recurrence in head and neck cancer patients

Yokosawa, Eva B.; Arthur, Anna E.; Rentschler, Katie M.; Wolf, Gregory T.; Rozek, Laura S.; Mondul, Alison M.

doi:10.1002/lary.27256

Cited by 23 publications

(29 citation statements)

References 25 publications

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“…We were unable to find studies assessing deep‐fried food intake and HNC survival. No studies have evaluated fruit and vegetable intake and survival in the context of HPV status …”

Section: Introductionmentioning

confidence: 99%

Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000

et al. 2019

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Background: The association between diet and head and neck cancer (HNC) survival is unclear. Methods: Cox proportional hazard models measured the association between fruit, vegetable, and deep-fried food intake and HNC overall survival adjusting for clinical, social and lifestyle variables including smoking, alcohol, and HPV status. Results: Fruit and vegetable intake and improved survival were associated in minimally adjusted analyses. Following adjustment for smoking and alcohol consumption (fully adjusted analyses), the association with survival disappeared for fruit (HR 0.91, 95% CI 0.67, 1.23; P for trend = .55) and attenuated for vegetables (HR 0.79, 95% CI 0.61, 1.03; P for trend = .04). We observed no association between survival and deep-fried food intake in minimally adjusted or fully adjusted analyses (HR 0.88 95% CI 0.72, 1.07; P for trend = .13). Conclusions: Vegetable intake and HNC survival are modestly associated. There is some confounding by tobacco and alcohol consumption. K E Y W O R D Sdeep-fried food, fruit, head and neck cancers, survival, vegetables

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“…We were unable to find studies assessing deep‐fried food intake and HNC survival. No studies have evaluated fruit and vegetable intake and survival in the context of HPV status …”

Section: Introductionmentioning

confidence: 99%

Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000

et al. 2019

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“…Thus, the objective of this prospective pilot study was to assess vitamin D status in newly diagnosed HNC patients stratified by race and to gain potential mechanistic insight by performing in vitro studies utilizing human HNC cell lines. Among Whites vitamin D status is inversely associated with HNC, low vitamin D levels in White HNC patients is also linked to cancer progression, increased recurrence, and metastatic disease [13,14,19]. Despite well documented hypovitaminosis D in Blacks, vitamin D status has not been assessed in HNC patients stratified by race.…”

Section: Discussionmentioning

confidence: 99%

“…Research assessing potential biological mechanisms underlying HNC in racially diverse populations is lacking, as is information on the contribution of modifiable dietary factors to HNC incidence and progression. An inverse association between vitamin D status and cancer incidence, prognosis, and mortality has been reported in several cancer types, HNC included [10][11][12][13][14]. Moreover, it is well documented that Black Americans are at a higher risk for low vitamin D status, yet the link between HNC and vitamin D status has not been evaluated among Black patients [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…It has been speculated that vitamin D has potential anticarcinogenic effects through multiple biologic functions; however, clinical interventions and observational studies evaluating vitamin D have yielded mixed results across different cancers [10]. Nonetheless, a recent prospective cohort study targeting HNC in a population without race reported shows that higher vitamin D intake levels are associated with decreased risk of HNC recurrence [13]. Conversely, vitamin D deficiency has been linked to lymphatic metastasis among HNC patients [19].…”

Section: Introductionmentioning

confidence: 99%

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Disparities in Head and Neck Cancer: A Case for Chemoprevention with Vitamin D

et al. 2020

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Blacks experience disproportionate head and neck cancer (HNC) recurrence and mortality compared to Whites. Overall, vitamin D status is inversely associated to HNC pointing to a potential protective linkage. Although hypovitaminosis D in Blacks is well documented it has not been investigated in Black HNC patients. Thus, we conducted a prospective pilot study accessing vitamin D status in newly diagnosed HNC patients stratified by race and conducted in vitro studies to investigate mechanisms associated with potential cancer inhibitory effects of vitamin D. Outcome measures included circulating levels of vitamin D, related nutrients, and risk factor characterization as well as dietary and supplemental estimates. Vitamin D-based in vitro assays utilized proteome and microRNA (miR) profiling. Nineteen patients were enrolled, mean circulating vitamin D levels were significantly reduced in Black compared to White HNC patients, 27.3 and 20.0 ng/mL, respectively. Whites also supplemented vitamin D more frequently than Blacks who had non-significantly higher vitamin D from dietary sources. Vitamin D treatment of HNC cell lines revealed five significantly altered miRs regulating genes targeting multiple pathways in cancer based on enrichment analysis (i.e., negative regulation of cell proliferation, angiogenesis, chemokine, MAPK, and WNT signaling). Vitamin D further altered proteins involved in cancer progression, metastasis and survival supporting a potential role for vitamin D in targeted cancer prevention.

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“…In einer prospektiven Kohortenstudie wurden 434 Patienten mit Kopf-Hals-Tumoren mittels Ernährungsfragebogen befragt und die Supplementierungen erfasst. Es zeigte sich eine inverse Assoziation zwischen der Vitamin-D-Aufnahme und der Rezidivrate (Q4 vs. Q1 HR 0,47; 95 %-KI: 0,20-1,10; p = 0,048) [72].…”

Section: Wirksamkeit In Bezug Auf Den Verlauf Der Tumorerkrankungunclassified

Mikronährstoffe in der Onkologie: Risiko und Nutzen – Update 2020

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et al. 2020

TumorDiagnostik & Therapie

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Zusammenfassung Hintergrund Das Interesse sowohl von betreuenden Ärzten als auch Tumorpatienten an der zusätzlichen Einnahme von Mikronährstoffen während einer onkologischen Therapie mit unterschiedlichen Intentionen nimmt zu. Dieses Update liefert deshalb eine Standortbestimmung zum zusätzlichen Einsatz von ausgewählten Mikronährstoffen während der Tumortherapie. Methoden Es wurde eine Literaturrecherche hinsichtlich des Einsatzes von ausgewählten Mikronährstoffen in der Onkologie, die bis 2018 in zitierfähigen Journalen erschienen sind, durchgeführt. Ergebnisse Daten zu Mikronährstoffen, die sowohl hinsichtlich der Lebensqualität als auch der Prognose einen Nutzen für onkologische Patienten bringen, als auch Erkenntnisse zu Mikronährstoffen, die für die Patienten keinen Benefit haben oder sogar schaden, werden präsentiert. Die gute Datenlage hinsichtlich Vitamin D und Selen erlaubt hier die Empfehlung zur Supplementation nach Spiegelbestimmung im Serum. Schlussfolgerung Nicht nur vorrangig onkologisch tätige Ärzte, sondern auch alle Ärzte, die Tumorpatienten mitbetreuen, sollten Kenntnisse über die wichtigsten Mikronährstoffe haben, um diese an die Patienten weiterzugeben und sie auch gezielt zum Nutzen der Patienten einzusetzen.

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Vitamin D intake and survival and recurrence in head and neck cancer patients

Abstract: 2b. Laryngoscope, E371-E376, 2018.

Cited by 23 publications

References 25 publications

Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000

Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000

Disparities in Head and Neck Cancer: A Case for Chemoprevention with Vitamin D

Mikronährstoffe in der Onkologie: Risiko und Nutzen – Update 2020

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