Vitamin profile of pregnant women living with HIV/AIDS

Machado, Rachel Helena Vieira; Bonafé, Simone Martins; Castelo, Adauto; Patin, Rose Vega

doi:10.1016/j.clnme.2013.03.002

Cited by 3 publications

(12 citation statements)

References 21 publications

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“…A high risk of bias arose from studies that did not mention [ 28 – 34 ] or control [ 35 – 37 ] for confounders in their analysis (53%, n = 9). Other studies did not provide a definition of outcome (41%, n = 7), [ 28 , 29 , 31 – 33 , 37 , 38 ] used data originating from hospital databases (41%, n = 7) or had missing data (41%, n = 7). Most studies selected a study population that was representative of the target population (71%, n = 12).…”

Section: Resultsmentioning

confidence: 99%

“…NRTI nucleoside reverse transcriptase inhibitor, NNRTI non-nucleoside reverse transcriptase inhibitor, PI protease inhibitor, cART combined antiretroviral treatment. Grading of dyslipidemia according to DAIDS [ 39 ], or non-graded incidence of dyslipidemia not specifying the definition of ‘dyslipidemia.’ (crosses) [ 31 , 32 , 41 ] …”

Section: Resultsmentioning

confidence: 99%

“…Three studies reported a not further defined ‘incidence of dyslipidaemia’ of 0–7.5% [ 31 , 32 , 41 ]. Areechokchai et al [ 41 ] found three cases (1.2%) of dyslipidaemia in participants on a first generation PI-based regimen (indinavir).…”

Section: Resultsmentioning

confidence: 99%

“…Areechokchai et al [ 41 ] found three cases (1.2%) of dyslipidaemia in participants on a first generation PI-based regimen (indinavir). The other two studies did not mention the type of ART used and reported no cases of dyslipidemia [ 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…This finding was supported by studies included in this review that compared PI use to other ART regimens [ 26 , 28 , 30 ]. The highest serum lipid concentrations found in this review were derived from studies that used first generation PI-based ART regimens [ 27 , 29 , 30 , 33 , 37 , 40 , 42 ], while the lower values did not use PIs, or used second generation PIs [ 27 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

et al. 2017

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BackgroundObserved adverse effects of antiretroviral therapy (ART) on the lipid profile could be of significance in pregnancy. This systematic review aims to summarize studies that investigated the association between HIV, ART and serum lipids during pregnancy and adverse pregnancy outcomes.MethodsA systematic search was conducted in five electronic databases to obtain articles that measured serum lipid concentrations or the incidence of dyslipidaemia in HIV-infected pregnant women. Included articles were assessed for quality according to the Cochrane Risk of Bias Tool. The extracted data was analysed through descriptive analysis.ResultsOf the 1264 articles screened, 17 articles were included in this review; eleven reported the incidence of dyslipidaemia, and twelve on maternal serum lipid concentrations under the influence of HIV-infection and ART. No articles reported pregnancy outcomes in relation to serum lipids. Articles were of acceptable quality, but heterogenic in methods and study design. Lipid levels in HIV-infected women increased 1.5–3 fold over the trimesters of pregnancy, and remained within the physiological reference range. The percentage of women with dyslipidaemia was variable between the studies [0–88.9%] and highest in the groups on first generation protease inhibitors and for women on ART at conception.ConclusionThis systematic review observed physiologic concentrations of serum lipids for HIV-infected women receiving ART during pregnancy. Serum lipids were increased in users of first generation protease inhibitors and for those on treatment at conception. There was no information available about pregnancy outcomes. Future studies are needed which include HIV-uninfected control groups, control for potential confounders, and overcome limitations associated with included studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2581-8) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

et al. 2017

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Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Lucchetta

Lemos

Gini

et al. 2022

Rev Bras Ginecol Obstet

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Objective To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil. Methods A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. Results Our review identified 31 studies, comprising 4,006 participants. All the studies had at least one weakness, mainly due to the use of convenience sampling and small sample size. The overall prevalence of vitamin D deficiency, insufficiency, and both deficiency and insufficiency were 35% (confidence interval, 95%CI: 34–37%), 42% (95%CI: 41–44%), and 72% (95%CI: 71–74%), respectively. Conclusion Although the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems.

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Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

et al. 2021

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BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. REGISTRATION NUMBER IN PROSPERO: CRD42020221605.

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Vitamin profile of pregnant women living with HIV/AIDS

Cited by 3 publications

References 21 publications

The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

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