Vitamin P Protection against Radiation

Inhibition of Growth by Benzene Hexachloride Isomers and Protective Effect of Glucose as Measured by Cell Counting Technique

“…D'AMATO (12), on the other hand, reported a delaying action of meso-inositol on the C-mitotic and C-tumor action of gamma benzene hexachloride, which occurred at 15 to 190 C, but not at 26 to 270 C. D'Amato also observed a delaying action of sucrose and other sugars and ascribed these effects to a change in permeability to the BHC. Antagonisms of this type are suggestive of those observed against x-radiation by sodium cyanide (3), thiourea (31) and vitamin P (41). LEVAN and OSTERGREN (30) have discussed the mechanism of C-mitotic action at some length.…”

Experimentelle Untersuchungen über die Strahlenschutzwirkung von Trihydroxyaethyl-Rutosid (Venoruton P₄)

“…

[4,23,26,6,38,39,24,22,7,15,44,2]. Die Ent wicklung des THR ermöglichte, einen hochgradig wasserlöslichen, praktisch atoxischen Wirkstoff mit guter Verträglichkeit in die Therapie cinzuführen.

Die pharmakologischen Daten über Flavonoide sind vor allem in der Monographie von Böhm [5,8,9] zusammengestellt.

…”

“…[2], Sokoloff ct al. [38,39,40,41], Iiekers et al [35], Cohen et al [11], Clark [7,8,9,10] fanden Strahlenschutzcigenschaften im Tierversuch, sowie am Menschen: einen lokalen protektiven Effekt an Hautkapillarcn, eine Herabsetzung der Mortalität von 80% auf 40% [40] bzw. von 72% auf 24% [2].…”

The Biological Activity of a Flavonoid (Vitamin “P”) Compound 12

“…A method was suggested for the estimation of vitamin "P" activity by using the capillary bed in the rat-mesoappendix, with a compound topically applied. It was found, however, that most of the flavonoid compounds, except catechins, did not produce any vasoconstrictor effect (9,10). Considerable work was done with the determination of capillary permeability by using chloroform wheals applied to the skin and simultaneous injections of trypan blue.…”

“…Purpura, for which ascorbic acid has proved ineffective, has been a constant feature of radiation illness. It has been shown that some flavonoid compounds exert protective action against radiation injury to the capillary system (13)(14)(15)(16)(17)(18).…”