Vitamin levels and clinical status in cystic fibrosis

Grey, Vijaylaxmi; Lands, L. C.; Grenier, C.; Drury, Donna

doi:10.1016/s0009-9120(97)88982-5

Clinical Biochemistry

1997

DOI: 10.1016/s0009-9120(97)88982-5

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Vitamin levels and clinical status in cystic fibrosis

Vijaylaxmi Grey¹,

L. C. Lands²,

C. Grenier³

et al.

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2000

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“…The reasons for this are not clear. We and others have found that vitamin levels do not always correlate with standard measurements of clinical status such as pulmonary function (forced expiratory volume in 1 second; FEV 1 ) or growth and nutritional status (3,4), supporting the recommendation for routine biochemical assessment (5). Vitamin A and E levels depend on dietary intake, whereas vitamin D is related to both exposure to sunlight and dietary intake.…”

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confidence: 79%

Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis

Grey,

Lands,

Pall

et al. 2000

J. pediatr. gastroenterol. nutr.

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Background:Patients with cystic fibrosis are at risk for malabsorption of fat‐soluble vitamins, and those with low 25‐OH vitamin D levels have a higher risk of low bone mineral density and long‐term skeletal complications. It is currently recommended that vitamins A and E be monitored yearly; however, no recommendations exist for 25‐OH vitamin D. Because all three vitamins are fat‐soluble, the hypothesis in the current study was that low levels of vitamins A and E could identify patients at risk for low 25‐OH vitamin D, so that 25‐OH vitamin D measurements could be obtained in only selected circumstances.Methods:Forty (21 girls) patients with CF, age 10.5 ± 3.9 (SD) years, were assessed in a cross‐sectional survey for ideal weight for height (percentage of predicted), spirometry (percentage of predicted FEV1, 33/40 patients), and serum levels of vitamins A, E, 25‐OH vitamin D, and cholesterol (37/40 patients).Results:Nine (22.5%) of 40 patients were malnourished (percentage of predicted ideal weight for height <85%), 7 (21.2%) of 33 had moderate to severe lung disease (FEV1 <60%), 4 (10%) of 40 had low levels of vitamin A, 3 (7.5%) of 40 had low vitamin E levels, 4 (10.8%) of 37 low vitamin E/cholesterol levels, and 4 (10%) of 40 had marginal or low levels of 25‐OH vitamin D (<40 mmol/l). The patients with low 25‐OH vitamin D were older, with no child < 12 years of age having a 25‐OH vitamin D level less than 40 mmol/l. They also had lower vitamin E and vitamin E/cholesterol levels than those with normal 25‐OH vitamin D levels. The groups did not differ in percentage of predicted ideal weight for height, lung function, or vitamin A levels. The best positive predictor for 25‐OH vitamin D less than 40 mmol/l was low vitamin E (66.7%), with a negative predictive value of 94.6%. 25‐OH vitamin D levels correlated with vitamin E/cholesterol levels (r = 0.41, P < 0.01) and weakly with vitamin E levels (r = 0.28, P < 0.08), but not with vitamin A levels.Conclusions:These results suggest that children aged less than 12 years and older children with normal vitamin E levels are especially unlikely to have low 25‐OH vitamin D levels, and this measure can therefore be omitted. In contrast, those children with low vitamin E levels may warrant monitoring.

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confidence: 79%

Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis

Grey,

Lands,

Pall

et al. 2000

J. pediatr. gastroenterol. nutr.

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Monitoring of 25-OH Vitamin D Levels in Children With Cystic Fibrosis

Grey

Lands²,

Pall³

et al. 2000

Journal of Pediatric Gastroenterology and Nutrition

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Vitamin levels and clinical status in cystic fibrosis

Cited by 2 publications

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Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis

Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis

Monitoring of 25-OH Vitamin D Levels in Children With Cystic Fibrosis

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