Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

Zhang, Meiyu; Miura, Taro; Suzuki, Shunsuke; Chiyotanda, Masako; Tanaka, Sachiko; Sugiyama, Kentaro; Kawashima, Hisashi; Hirano, Toshihiko

doi:10.1248/bpb.b20-00079

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Intelectin-1 (ITLN1, can induce ERK phosphorylation and help to amplify the T H 2 responses) is overexpressed in AD skin lesions, accompanied by significant expression of allergen-induced TSLP, IL-33, and IL-25 ( Tsuji et al, 2001 ; Yi et al, 2017 ). In AD therapies for the pediatric population, vitamin K2 exerts an anti-inflammatory effect by means of inhibiting the JNK signaling and ERK1/2 phosphorylation ( Zhang et al, 2021 ). Above studies present that MAPKs phosphorylation is a crucial biologic activator in triggering immune responses and amplifying allergic inflammation in the pathogenesis of AD.…”

Section: Involvement Of Post-translational Modifications In Adsmentioning

confidence: 99%

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Luo

et al. 2022

Front. Cell Dev. Biol.

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Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.

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Section: Involvement Of Post-translational Modifications In Adsmentioning

confidence: 99%

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Luo

et al. 2022

Front. Cell Dev. Biol.

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“…Vitamin K2 suppresses proliferation and inflammatory cytokine production in mitogen-activated lymphocytes of atopic dermatitis patients through the Inhibition of mitogen-activated protein kinases [29].…”

Section: Vitamin Kmentioning

confidence: 99%

Vitamins and Cancer Immunotherapy

Dochniak¹

2022

GSC Adv. Res. Rev.

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Vitamins are essential for cellular growth and nutrition. The bioavailability of vitamins may affect the immune system’s ability to fight cancer. Research efforts investigate the complex interplay of vitamins, immune cells, and cancer cells to improve treatment outcomes. This review explores managing the intake of vitamin A, B, C, D, E, and K to enhance the efficacy of forced-atopy cancer immunotherapy.

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“…Th2-based allergic inflammation plays a dominant role in the early stages of an acute outbreak of AD, which leads to the raised levels of IL-4, IL-13, and IgE [ 7 ]. However, Th1-dominant allergic inflammation is predominated in the chronic phase of AD and mainly releases IL-2, TNF- α , and IFN- γ [ 8 , 9 ]. Moreover, multiple inflammatory cells are found in the epidermis and dermis of AD patients including mast cells, monocytes/macrophages, eosinophils, and T lymphocytes [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Ta-Xi-San Suppresses Atopic Dermatitis Involved in Multitarget Mechanism Using Experimental and Network Pharmacology Analysis

Zhi

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Atopic dermatitis (AD) is a relapsing and chronic skin inflammation with a common incidence worldwide. Ta-Xi-San (TXS) is a Chinese herbal formula usually used for atopic dermatitis in clinic; however, its active compounds and mechanisms of action are still unclear. Our study was designed to reveal the pharmacological activities, the active compounds, and the pharmacological mechanisms of TXS for atopic dermatitis. Mice were induced by 2,4-dinitrocluorobenzene (DNCB) to build atopic dermatitis model. The pathological evaluation, enzyme-linked immunosorbent assay (ELISA), and hematoxylin and eosin (H&E) assay were performed. The UPLC-Q-Exactive-MSE and network pharmacology analysis were performed to explore active ingredients and therapeutic mechanisms of TXS. TXS treatment decreased levels of immunoglobulin E (IgE), interleukin-4 (IL-4), and tumor necrosis factor-α (TNF-α) in serum induced by DNCB. TXS reduced scratching behavior and alleviated inflammatory pathology of skin and ear. Meanwhile, TXS decreased the spleen index and increased spleen index. The UPLC-Q-Exactive-MSE results showed that 65 compounds of TXS were detected and 337 targets were fished. We collected 1371 AD disease targets, and the compound-target gene network reveled that the top 3 active ingredients were (−)-epigallocatechin gallate, apigenin, and esculetin, and the core target genes were PTGS2, PTGS1, and HSP90AA1. The KEGG pathway and GO analysis showed that TXS remedied atopic dermatitis via PI3K-Akt signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, and Toll-like receptor (TLR) signaling pathway with the regulation of inflammatory response and transcription. Further, we found that the targets of PTGS2 and HSP90AA1 were both elevated in ears and skin of AD model mouse; however, TXS decreased the elevated expressions of PTGS2 and HSP90AA1. Our study revealed that TXS ameliorated AD based on (−)-epigallocatechin gallate, apigenin, and esculetin via targeting PTGS2 and HSP90AA1.

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Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

Cited by 6 publications

References 38 publications

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Vitamins and Cancer Immunotherapy

Ta-Xi-San Suppresses Atopic Dermatitis Involved in Multitarget Mechanism Using Experimental and Network Pharmacology Analysis

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