Vitamin K2, MicroRNA-210 and mitochondrial DNA copy number: Implications in prediction, prevention and personalized treatment of hepatocellular carcinoma?
Abstract:Introduction:
Hypoxia is a major feature of hepatocellular carcinoma (HCC). The master hypoxamir, MIRNA-210, controls many carcinogenic pathways. Hypoxia can affect mitochondrial DNA copy number (MTCN), which could impair many mitochondrial functions, including electron transport chain (ETC). Vitamin K2 (VK2) is crucial for preserving ETC integrity.
Aim of the study:
To evaluate the role of MTCN, MIRNA-210 and VK2 in HCC prediction, prevention and personalized treatment.
Methodology:
60 cirrhotic patients w… Show more
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