Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats

Elkattawy, Hany A.; Ghoneim, Fatma M; Eladl, Mohamed Ahmed; Said, Eman; Ebrahim, Hasnaa Ali; El-Shafey, Mohamed; Asseri, Saad Mohamed; El-Sherbiny, Mohamed; Alsalamah, Reem Hamoud; Elsherbiny, Nehal M.; Hadhod, Shimaa

doi:10.3390/antiox11030514

Cited by 4 publications

(4 citation statements)

References 46 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the VK2 activation of Gas-6 and Protein S provided protection against neuronal ischemic/hypoxic injury via antiapoptotic and anti-inflammatory effects [ 51 ]. In context, VK2 successfully restored the oxidative/antioxidative balance with a parallel suppression of inflammatory genetic expression in the brain of naturally aging rats [ 27 ], which gives further credence to the observations of the current study. Moreover, VK2 suppressed TNF-α in human lymphocytes, fibroblasts and astrocytes, where inflammation is induced by various agents [ 52 ].…”

Section: Discussionsupporting

confidence: 76%

“…The animals were first acclimatized for one week under standard laboratory conditions. Then, the rats were randomly assigned into two groups ( n = 10): Aged untreated rats: rats received sunflower oil (vehicle) for 17 months, and Aged-treated rats: rats received VK2 (MK-7) at a dose of 30 mg/kg 5 days per week for 17 months [ 27 ]. An additional group of adult rats (three months age, n = 10) was used as the adult control group.…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, many studies supported a protective efficacy for VK in age-related conditions [ 26 ]. In this context, the protective effect of MK-7 against age-induced structural changes and cognitive deficit in naturally aged rats has been referred to [ 27 ]. However, the protective effect of VK against structural and functional changes in aged liver has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aging is a naturally occurring physiological process with a deleterious impact on various body organs and humans’ well-being. The aging population is increasing worldwide, which imposes the need for the exploration of nutritional options that can intercept the impact of the aging processed on various body organs. Vitamin K2 (VK2) is a fat-soluble vitamin with emerging evidence on its therapeutic merits. In the current study, natural aging induced a significant liver deterioration with a disrupted Keap-1/Nrf-2/HO-1 axis and increased COX-2, iNOS and TNF-α expression and apoptotic and fibrotic changes. VK2 administration, on the other hand, improved the biochemical indices of liver function (total protein, albumin, ALT and AST); the suppressed hepatic expression of Keap-1 and increased the hepatic expression of Nrf-2 with a parallel increase in the hepatic activity of HO-1. Subsequently, the liver content and hepatic expression of TNF-α, COX-2 and iNOS were significantly retracted. In context, the liver content and hepatic expression of the fibrotic biomarkers TGFβ and TIMP significantly retracted as well. Moreover, the TUNEL assay confirmed the retraction of liver apoptotic changes. Of notice, electron transmission microscope examination confirmed the preservation of mitochondrial functions and preservation of the ultra-microscopical structures. In conclusion, the VK2-mediated interception of aging-induced Keap-1/Nrf-2/HO-1 signaling suppressed the hepatic contents of inflammatory and fibrotic biomarkers, as well as apoptotic changes with preservation of the hepatic architectural and functional status. VK2 can be presumed to be an effective nutritional supplement to the aging population to spare the liver, amongst other body organs, against aging-induced deleterious injury.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…These interactions have not been examined in horses and question the arbitrary micronutrient supplementation practiced in some racehorse stables (Southwood et al 1993). The interaction between VK and the antioxidant glutathione also warrants further investigation in the horse, with in vitro studies in rats suggesting that VK inhibits glutathione depletion (Elkattawy et al 2022).…”

Section: Interactions With Other Nutrientsmentioning

confidence: 99%

Vitamin K: history, metabolism, and nutrition in the horse

Skinner

Cawdell-Smith²,

Biffin³

et al. 2023

Anim. Prod. Sci.

View full text Add to dashboard Cite

Vitamin K (VK) has long been known for its essential role in blood coagulation. However, over the past decade, evidence has mounted for its intrinsic and essential roles in other functions within the body, including bone metabolism, calcification, brain development and glucose metabolism. Thus, VK should no longer be considered a single-function 'haemostasis vitamin', but rather as a 'multi-function vitamin'. While current research has focused on its emerging role in human nutrition, the role that VK plays in other species such as the horse has not been well described, with most of our current understanding having been extrapolated from other species, especially rodents. This review assesses the current state of knowledge of VK as it pertains to human and animal nutrition, and, where data exist, its metabolism and nutrition in the horse is explored. Future research on the roles of VK as they pertain to horses, particularly extra-hepatic functions, is necessary. Such insight will allow a greater understanding of how VK is metabolised, facilitating the development of recommendations to assist in the health, growth, and longevity of horses.

show abstract

Does Improving Depression Symptoms in Young Adults With Inflammatory Bowel Disease Alter Their Microbiome?

Davies,

Teh,

Ewais

et al. 2024

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

Background Patients with inflammatory bowel diseases (IBDs) are more likely to have depression and anxiety symptoms compared with healthy individuals and those with other chronic illnesses. Previous studies have shown a link between the microbiome composition and depression symptoms; however, many antidepressant medications have antibacterial activity confounding cross-sectional studies of these populations. Therefore, we aimed to determine whether we could detect longitudinal changes in the microbiome of a subset of patients who participated in a previously published mindfulness-based cognitive therapy (MBCT) study to improve depression symptoms in adolescents and young adults with IBD. Methods Stool samples were collected at baseline and 8 weeks (n = 24 participants, 37 total samples, 13 paired samples). During this time, some participants achieved a 50% reduction in their depression symptoms either through MBCT or treatment as usual with their mental health team (responders). The microbiome composition and function of responders were compared with participants who did not improve their depression scores (nonresponders). Depression scores were determined using the depression, anxiety, and stress score (DASS-21), and metagenomic sequencing of stool samples was performed. Results No difference in alpha diversity was found between responders and nonresponders. Beta diversity measures were similarly unchanged. Clinical features including fecal calprotectin, C-reactive protein, and serum IL-6 levels were unchanged. Conclusions In this small longitudinal study, we were not able to detect longitudinal changes in the microbiome associated with improvement in depression scores. Follow-up studies that are sufficiently powered to detect changes in the microbiome are required to confirm our results.

show abstract

Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats

Cited by 4 publications

References 46 publications

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat

Vitamin K: history, metabolism, and nutrition in the horse

Does Improving Depression Symptoms in Young Adults With Inflammatory Bowel Disease Alter Their Microbiome?

Contact Info

Product

Resources

About