Vitamin K2 and serum cholesterol in patients on continuous ambulatory peritoneal dialysis

Nagasawa, Yasuyuki; Fujii, Masamitsu; Kajimoto, Yoshiteru; Imai, Enyu; Hori, Miyuki

doi:10.1016/s0140-6736(05)78492-0

Cited by 36 publications

(20 citation statements)

References 3 publications

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“…This is consistent with findings reported by the Framingham Offspring Cohort, in which higher phylloquinone intake was associated with a lipid profile indicative of decreased risk of cardiovascular disease, including higher HDL, lower ratios of low-density lipoprotein (LDL) cholesterol, and lower TG [31]. A previous study conducted in dialysis patients also demonstrated a favorable effect of menaquinone supplementation on blood lipids [38]. In that study, researchers reported that oral administration of menaquinone (45 mg/d) significantly lowered total cholesterol, LDL cholesterol, and TG concentrations in 17 patients.…”

Section: Discussionsupporting

confidence: 91%

Dietary Phylloquinone Intakes and Metabolic Syndrome in US Young Adults

Pan

Jackson

2009

Journal of the American College of Nutrition

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Mean reported dietary phylloquinone intakes suggested that most US young adults consume an insufficient amount of vitamin K from their diet. A high intake of phylloquinone may favorably affect MetS or its components, probably through an overall more heart-healthy dietary pattern. The pathogenesis of MetS is profoundly complex and may involve other factors and/or mechanisms, in addition to vitamin K nutriture. Although our data suggest a potential role of vitamin K in MetS, the biological mechanisms underlying the observed associations must be elucidated.

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Section: Discussionsupporting

confidence: 91%

Dietary Phylloquinone Intakes and Metabolic Syndrome in US Young Adults

Pan

Jackson

2009

Journal of the American College of Nutrition

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“…The limited evidence from human studies suggests that high menaquinone intake may improve the blood lipid profile [29]. Our study showed that 270-days of vitamin K2 supplementation did not affect blood lipids.…”

Section: Discussioncontrasting

confidence: 41%

Plasma Desphospho-Uncarboxylated Matrix Gla Protein as a Marker of Kidney Damage and Cardiovascular Risk in Advanced Stage of Chronic Kidney Disease

Kurnatowska

Grzelak

Masajtis-Zagajewska

et al. 2016

Kidney Blood Press Res

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Background/Aims: Desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) is formed as a result of vitamin K insufficiency. The aim of this study was to investigate the association between plasma dp-ucMGP, kidney function and cardiovascular risk factors before and after 9-months substitution of vitamin K2 in non-dialysis patients with chronic kidney disease (CKD) stage 4 and 5. Methods: 38 CKD patients were supplemented for 270±12 days with 90 µg vitamin K2 and 10 µg cholecalciferol or 10 µg cholecalciferol alone. At baseline and at follow-up circulating calcium, phosphate, lipids, hemoglobin, albumin and total protein, dp-ucMGP, osteoprotegerin, fetuin A, osteocalcin and fibroblast grown factor 23 (FGF-23) were assessed. Proteinuria was assessed in the first morning void. Results: Baseline plasma dp-ucMGP was 1018.6±498.3 pmol/l and was significantly higher in patients at stage 5 CKD (1388.3 ±505.4 pmol/l) than at stage 4 (885.1±419.7 pmol/l), p=0.04. Vitamin K2 supplementation resulted in a decrease of dp-ucMGP level by 10.7%. Plasma dp-ucMGP was positively associated with proteinuria, serum creatinine, PTH and FGF-23; and inversely associated with glomerular filtration rate, serum hemoglobin and albumin. Conclusions: High dp-ucMGP level, reflecting a poor vitamin K status seems to be associated with kidney damage and may be also a marker of cardiovascular risk in CKD patients. Supplementation with vitamin K2 may improve the carboxylation status of MGP.

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“…A strong linear correlation was noted between changes over time of ΔCACS and ΔCCA-IMT in 30 showed a decrease in total and LDL cholesterol levels after 6 months of supplementation with 45 µg of vitamin K in patients on peritoneal dialysis. We did not observe any significant effect of vitamin K 2 substitution on lipid levels, but all our study patients were treated with statins before and during vitamin substitution.…”

Section: Discussionmentioning

confidence: 81%