Vitamin K

Ferland, Guylaine

doi:10.1002/9781119946045.ch15

Cited by 14 publications

(9 citation statements)

References 120 publications

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“…It can be postulated that they may involve changes in local tissue environments induced by disturbed functions of extrahepatic VKDPs. For example, some VKDPs, such as osteocalcin and matrix Gla protein (MGP), localize in bone, cartilage, vessels and smooth muscle where they regulate mineralization and calcification of extracellular matrix (Ferland, 2012a ; Krueger et al, 2009 ; Shea and Holden, 2012 ; Theuwissen et al, 2012 ). Still, more studies are warranted to examine these relationships.…”

Section: Discussionmentioning

confidence: 99%

“…A growing number of studies have shown that low vitamin K intake or plasma concentration is associated with increased risk of aging-related health outcomes including cardiovascular diseases, hip fractures, insulin resistance, inflammation, and cognitive impairment in adult and elderly populations (Booth, 2009 ; Ferland, 2012a , 2012b ; McCann and Ames, 2009 ). In addition, a sufficient number of studies have reported an association of VK status with markers of bone metabolism and bone mineral content, suggesting a role in bone health in growing children (Cashman, 2005 ; Kalkwarf et al, 2004 ; O'Connor et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

“…Of at least 15 VKDPs identified, 7 proteins are either blood coagulants (factor II, X, VII, and IX) or anti-coagulants (Protein C, S, and Z), all carboxylated in the liver (McCann and Ames, 2009 ). Some extrahepatic VKDPs are extracellular matrix proteins functioning as regulators of bone mineral maturation and inhibitors of calcification of smooth muscle or vascular endothelium, but the physiological functions of others remain elusive (Ferland, 2012a ; McCann and Ames, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

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Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children

Lee

Schulze

Cole

et al. 2016

OMICS: A Journal of Integrative Biology

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Vitamin K (VK) is a fat-soluble vitamin whose deficiency disrupts coagulation and may disturb bone and cardiovascular health. However, the scale and systems affected by VK deficiency in pediatric populations remains unclear. We conducted a study of the plasma proteome of 500 Nepalese children 6–8 years of age (male/female ratio = 0.99) to identify proteins associated with VK status. We measured the concentrations of plasma lipids and protein induced by VK absence-II (PIVKA-II) and correlated relative abundance of proteins quantified by mass spectrometry with PIVKA-II. VK deficiency (PIVKA-II >2 μg/L) was associated with a higher abundance of low-density lipoproteins, total cholesterol, and triglyceride concentrations (p < 0.01). Among 978 proteins observed in >10% of the children, five proteins were associated with PIVKA-II and seven proteins were differentially abundant between VK deficient versus sufficient children, including coagulation factor-II, hemoglobin, and vascular endothelial cadherin, passing a false discovery rate (FDR) threshold of 10% (q < 0.10). Among 27 proteins associated with PIVKA-II or VK deficiency at a less stringent FDR (q < 0.20), a network comprised of hemoglobin subunits and erythrocyte anti-oxidative enzymes were highly and positively correlated each other (all r > 0.7). Untargeted proteomics offers a novel systems approach to elucidating biological processes of coagulation, vascularization, and erythrocyte oxidative stress related to VK status. The results may help elucidate subclinical metabolic disturbances related to VK deficiency in populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children

Lee

Schulze

Cole

et al. 2016

OMICS: A Journal of Integrative Biology

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“…Historically discovered for its role in blood coagulation, vitamin K (VK) has recently emerged as an important nutrient for brain function. Vitamin K occurs naturally in two forms, phylloquinone which originates from plants, is the main dietary source, while the menaquinones, which are of bacterial origin, constitute a family of compounds with unsaturated isoprenyl side chains of various lengths ( Ferland, 2012a ; Shearer and Newman, 2014 ). One of the menaquinones, menaquinone-4 (MK-4), is not a common product of bacterial synthesis but is synthesized from phylloquinone ( Nakagawa et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats

Tamadon‐Nejad

Ouliass

Rochford

et al. 2018

Front. Aging Neurosci.

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Initially discovered for its role in blood coagulation, there is now convincing evidence that vitamin K (VK) has important actions in the nervous system. In brain, VK is present in the form of menaquinone-4 (MK-4), a byproduct of the main dietary source, phylloquinone. It contributes to the biological activation of various proteins (i.e., Gas6), and participates in the synthesis of sphingolipids, a class of lipids widely present in brain cell membranes with important cell signaling functions. In a previous study, we reported that lifetime consumption of a low VK diet resulted in mild cognitive impairment in aged rats, a finding associated with an alteration of the sphingolipid profile. To confirm the role of VK as it relates to sphingolipids, cognition, and behavior outside the context of aging, we conducted a study of acute VK deficiency using a pharmacological model of VK deficiency in brain. In this procedure, rats (8 weeks) are maintained on a ratio of warfarin (a VK antagonist) to VK whereby coagulation is maintained while inducing VK deficiency in extrahepatic tissues. After 10 weeks of treatment, rats who were subjected to the warfarin plus phylloquinone protocol (WVK) exhibited longer latencies in the Morris water maze test as well as lower locomotor activity and exploratory behavior in the open field test, when compared to control rats. The WVK treatment resulted in a dramatic decrease in MK-4 level in all brain regions despite the presence of high local concentrations of phylloquinone, which suggests an inhibition of the biosynthetic MK-4 pathway in the presence of warfarin. Additionally, WVK treatment affected sphingolipid concentrations in key brain regions, notably those of the ganglioside family. Finally, brain MK-4 was correlated with performances in the open field test. This study confirms the modulatory role of VK in cognition and behavior and the implication of sphingolipids, notably those of the ganglioside family.

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“…The risk of Vit K deficiency is increased in patients who are taking Vit K antagonist like anticoagulant drugs, and individuals with significant liver damage or disease ( Olson, 1999) . As well, individuals with fat malabsorption disorders may be at higher risk of Vit K deficiency ( Ferland, 2006) . Exogenous Vit K is required for carboxylation of osteocalcin, which in turn allows osteocalcin to bind to hydroxyapatite mineral.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study

Noori¹,

Lashkari²,

Oveisi³

et al. 2014

GJHS

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Objective:The aim of this study was to measure the level of Vitamin K2 (Vit K2) in osteoporotic patients and individuals with normal bone density as controls.Materials and Methods:This case-control study was done in Outpatient Department of Rheumatology at Qazvin Boo-ali Sina Hospital in 2013. Participants were 50 patients with osteoporotic densitometry measured by DEXA (T score≤ -2.5) who were matched with 48 persons in control group with normal bone density (T score> -1). The level of Vit K2 in samples was measured using enzyme linked immunosorbent assay (ELISA). Data were analyzed by Mann-Whitney U test and Chi-square test.Results:The level of Vit K2 in patients with osteoporosis was not significantly different from the control group (Median:75.95 vs. 71.35 nmol/L, respectively; P-value: 0.709). The authors determined cut-offs 75 percentile of vitamin K2 in all participants that was 85 nmol/L and percentages of persons in two groups were similar.Conclusion:Although Vit K2 level in patients with osteoporosis was not significantly different from the control group, further studies are necessary to confirm the association of osteoporosis and Vit K2.

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Vitamin K

Cited by 14 publications

References 120 publications

Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children

Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children

Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats

Assessment of Vitamin K2 Levels in Osteoporotic Patients: A Case Control Study

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