Vitamin E supplementation in people with cystic fibrosis

Okebukola, Peter O; Kansra, Sonal; Barrett, Joanne

doi:10.1002/14651858.cd009422.pub4

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…An earlier study by Kalvaria et al 24 also found that prevalence of vitamin E was higher in a sample of patients with CP when vitamin E to lipid ratio was determined (75%) compared with serum vitamin E alone (55%). Even in the cystic fibrosis literature, where research on fat‐soluble vitamins is more vast, many studies have failed to account for blood lipid when evaluating vitamin E status 25 …”

Section: Discussionmentioning

confidence: 99%

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

Estes‐Doetsch,

Roberts,

Newkirk

et al. 2023

Nut in Clin Prac

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Chronic pancreatitis (CP) is often associated with exocrine pancreatic insufficiency (EPI), which may increase risk for fat‐soluble vitamin depletion. Although vitamin D deficiency is widespread among the general population, vitamins A, E, and K deficiencies may more uniquely present in patients with CP. Yet, it is unclear whether fat‐soluble vitamin status should be routinely monitored in all patients with CP or limited to those with EPI. The purpose of this review is to describe the laboratory status of vitamins A, E, and K in adult patients with CP and their association with exocrine pancreatic function. Five primary, observational studies met the inclusion criteria for qualitative synthesis. Biochemical deficiencies in fat‐soluble vitamins were observed across trials but results varied with respect to whether EPI increased risk. Challenges related to the diagnosis and treatment of EPI along with potential confounders may contribute to the heterogeneity among study results. Although more studies are needed to determine the influence of pancreatic enzyme replacement therapy on fat‐soluble vitamin status as well as effective vitamin repletion strategies, clinicians should consider periodically screening for deficiencies in all patients with CP regardless of EPI to avoid associated health effects of vitamin depletion.

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Section: Discussionmentioning

confidence: 99%

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

Estes‐Doetsch,

Roberts,

Newkirk

et al. 2023

Nut in Clin Prac

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“…The CF care community has long been aggressively focused on the needs for antioxidant micronutrient supplements [12][13][14]16,17,[57][58][59], and particularly for the needs for lipophilic antioxidants such as vitamin E [17,18,23,24,[60][61][62][63]. Under strong inputs from the CF Foundation scientific community [14,16], a revised version of a micronutrient antioxidant cocktail was designed and is now marketed with this increased need in mind [58].…”

Section: Nuances For the Cf Communitymentioning

confidence: 99%

α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration

et al. 2022

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Background: Numerous abnormalities in cystic fibrosis (CF) could influence tocopherol absorption, transportation, storage, metabolism and excretion. We hypothesized that the oxidative distress due to inflammation in CF increases vitamin E utilization, which could be positively influenced by supplemental vitamin C administration. Methods: Immediately before and after receiving vitamin C (500 mg) twice daily for 3.5 weeks, adult CF patients (n = 6) with moderately advanced respiratory tract (RT) disease consumed a standardized breakfast with 30% fat and a capsule containing 50 mg each hexadeuterium (d6)-α- and dideuterium (d2)-γ-tocopheryl acetates. Blood samples were taken frequently up to 72 h; plasma tocopherol pharmacokinetics were determined. During both trials, d6-α- and d2-γ-tocopherols were similarly absorbed and reached similar maximal plasma concentrations ~18–20 h. As predicted, during vitamin C supplementation, the rates of plasma d6-α-tocopherol decline were significantly slower. Conclusions: The vitamin C-induced decrease in the plasma disappearance rate of α-tocopherol suggests that vitamin C recycled α-tocopherol, thereby augmenting its concentrations. We conclude that some attention should be paid to plasma ascorbic acid concentrations in CF patients, particularly to those individuals with more advanced RT inflammatory disease and including those with severe exacerbations.

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“…Publicaciones recientes proponen como enfoque terapéutico prometedor el uso de los metabolitos de la vitamina E para el tratamiento de enfermedades inflamatorias como el hígado graso no alcohólico, por lo que explorar opciones como el compuesto activo de la vitamina E, conocido como metabolito de cadena larga, derivado del metabolismo hepático del α-tocoferol resulta prometedor (53,55).…”

Section: Inflamación Enfermedades Hepáticas Y Vitamina Eunclassified

Función de las vitaminas D, E y K en condiciones especiales

Gallego¹,

Marulanda²,

Yepes³

et al. 2022

Perspect Nut Hum

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Antecedentes: se cuenta con recomendaciones de energía y nutrientes para población sana, sin embargo, nutrientes como la vitamina D, E, K se les atribuyen funciones importantes en diferentes situaciones de salud. Objetivo: explorar la efectividad de dosis dietarias y de suplementos de las vitaminas D, E y K en condiciones especiales de salud y enfermedad. Materiales y métodos: se realizó una búsqueda de documentos en las bases de datos Pubmed, Scopus, Sciencedirect, Lilacs, Scielo, Ebsco, y en textos especializados utilizando palabras claves: “vitamin D”, “vitamin E”, “vitamin K”, “health”, “disease”, “nutritional recommendations” Resultados: hay un importante número de estudios y revisiones sistemáticas que contribuyen con la evidencia y la discusión en cuanto efecto, dosis y tiempo las cuales arrojaron tanto desenlaces positivos como nulos Conclusión: los efectos de la vitamina D dietaria en la salud ósea están bien documentados y los suplementos de la misma acompañados de calcio están indicados en grupos poblaciones con riesgo de osteoporosis, pero no en otras condiciones clínicas. No hay suficiente evidencia sobre los beneficios de la vitamina E en el manejo o prevención de enfermedad hepática, cardiovascular o cáncer. La vitamina K podría ser importante en la salud ósea, sobre otras condiciones clínicas.

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Vitamin E supplementation in people with cystic fibrosis

Cited by 10 publications

References 43 publications

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

Fat‐soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients?

α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration

Función de las vitaminas D, E y K en condiciones especiales

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